MODERN APPROACHES FOR THE TREATMENT OF COUGH: CLINICAL AND PHARMACOLOGICAL ASPECTS

Authors

  • K. O. Zupanets National University of Pharmacy, Ministry of Health of Ukraine, Kharkiv, Ukraine
  • T. S. Sakharova National University of Pharmacy, Ministry of Health of Ukraine, Kharkiv, Ukraine
  • I. A. Otrishko National University of Pharmacy, Ministry of Health of Ukraine, Kharkiv, Ukraine
  • N. P. Bezugla National University of Pharmacy, Ministry of Health of Ukraine, Kharkiv, Ukraine
  • S. K. Shebeko National University of Pharmacy, Ministry of Health of Ukraine, Kharkiv, Ukraine
  • K. L. Ratushna National University of Pharmacy, Ministry of Health of Ukraine, Kharkiv, Ukraine
  • O. O. Andrieieva National University of Pharmacy, Ministry of Health of Ukraine, Kharkiv, Ukraine
  • V. V. Propisnova National University of Pharmacy, Ministry of Health of Ukraine, Kharkiv, Ukraine

DOI:

https://doi.org/10.11603/1811-2471.2022.v.i1.12982

Keywords:

cough, approaches to treatment, efficacy and safety of therapy, responsible self-medication

Abstract

SUMMARY. Optimization of the respiratory diseases treatment is an important medical and social problem of modernity, which is due to the significant prevalence of this pathology among the working-age population, constant progression, comorbidity and possible negative influence on the concomitant diseases.

The aim – to analyze the modern experience of using the drugs for symptomatic treatment of cough, as well as identify alternative ways to optimize pharmacotherapy.

The literature review presents modern views on the choice of symptomatic drugs for the treatment of cough, and focuses on various principles of therapeutic tactics. The basic principles of the responsible self-medication of patients at symptomatic treatment of cough as one of the main symptoms of inflammatory respiratory diseases are presented. The general information about the symptoms of respiratory diseases, the causes of their occurrence, classification and treatment tactics are presented. The modern classification and nomenclature of drugs used for the symptomatic treatment of cough are highlighted. The role of herbal medicine in the symptomatic treatment of cough was discussed and the rational choice of the optimal herbal medicine was justified according evidence-based medicine.

The literature analysis allowed for enough critical evaluation of the current state of the problem of symptomatic treatment of cough and determine the main directions of the selective approaches to the individualized choice of therapeutic tactics of patients with cough.

Conclusions. Cough treatment requires adequate and timely provision of an individual, clinical and pharmacological approaches to the choice of an optimal symptomatic drug. Focusing on each specific clinical situation with clinical and pharmacological positions will improve the efficacy and safety of patient’s therapy.

References

Tikhonov, O.I., Yarnykh, T.G., & Zupanets, I.A. (2010). Biofarmatsiia : pidruch. dlia stud. farmats. vuziv i fak. [Biopharmacy: textbook for students of pharm. facult.] Kharkiv: NUPh: Golden Pages [in Ukrainian].

Vakulenko, L.I., & Samochina, I.I. (2012). Vozmozhnosti fitoterapii v profilaktike ostrogo bronkhita kak oslozhneniya ORVI [Features of phytotherapy in the prevention of acute bronchitis as a complication of ARVI]. Medical Nature, 4, 34-38. Retrieved from: http://nbuv.gov.ua/UJRN/simmed_2015_5_44 [in Russian].

Hostryi bronkhit: nastanova 00129 [Acute bronchitis: instruction 00129]. Retrieved from: https://guidelines.moz.gov.ua [in Ukrainian].

Infektsii dykhalnykh shliakhiv u doroslykh : nastanova 00006 [Infections of respiratory tract in adults: instruction 00006]. Retrieved from: https://guidelines. moz.gov.ua [in Ukrainian].

Kardosh, P. (2019). Fitoterapiia pry hostromu bronkhiti: yaki dokazy my maiemo? [Phytotherapy in acute bronchitis: What evidence do we have?]. Zdorovia Ukrainy – Health of Ukraine, 18(463), 43-44. Retrieved from: http://www.health-ua.com [in Ukrainian].

Kukes, V.G. (2004). Klinicheskaya farmakologia [Clinical pharmacology]. Moskva : GEOTAR-MED [in Russian].

Zupanets, I.A., Chernykh, V.P., & Sakharova, T.S. (2012). Klinicheskaya farmatsiya (farmatsevticheskaya opeka) : ucheb. dlya studentov vyssh. med. (farmats.) ucheb. zavedeniy [Clinical pharmacy (pharmaceutical care): textbook. for students of higher. med. (pharm.) edu. est.]. Kharkiv: NUPh: Golden Pages [in Russian].

Chernykh, V.P., Zupanets, I.A., & Kupnovitsaya, I.G. (2015). Klinicheskaya farmatsiya : bazovyy ucheb. dlya studentov vyssh. farmats. ucheb. zavedeniya (farmats. fak.) IV urovnya akkreditatsii; [izd. dorabot. i dop.] [Clinical pharmacy: basic textbook. for students of higher. pharmacy. study. institutions (pharmaceutical faculty) IV level of accreditation; [ed. revisions. and add.]. Kharkiv: NUPh: Golden Pages [in Russian].

Kovalenko, V.N., Sur, S.V., & Zupanets, I.A. (2020). Kompendium 2020 – lekarstvennyye preparaty [Compendium 2020 – drugs]. Kyiv: Morion [in Russian].

Grodzinskii, A.M. (1991). Likarski roslyny : entsykl. dovid. [Medicinal plants: Encyclopedic Reference]. Kyiv: Main ed. URE [in Ukrainian].

Pnevmoniia : nastanova 00122 [Pneumonia: instruction 00122]. Retrieved from: https://guidelines.moz.gov.ua [in Ukrainian].

Popp, M. (2019). Hostryi bronkhit: fitoterapiia z pozytsii dokazovoi medytsyny [Acute bronchitis: Phytotherapy from the position of evidence-based medicine]. Zdorovia Ukrainy – Health of Ukraine, 4 (51), 23. Retrieved from: http://www.health-ua.com [in Ukrainian].

Pro zatverdzhennia Pereliku likarskykh zasobiv, dozvolenykh do zastosuvannia v Ukraini, yaki vidpuskaiutsia bez retseptiv z aptek ta yikh strukturnykh pidrozdiliv : nakaz MOZ Ukrainy vid 18.04.2019 r. №876. [On approval of the list of medicines authorized to use in Ukraine, which are released without prescriptions from pharmacies and their structural subdivisions: an order of the Ministry of Health of Ukraine dated 18.04.2019 No. 876]. Retrieved from: http://www.moz.gov.ua in Ukrainian].

Chernykh, V.P., Zupanets, I.A., & Lischishina, O.M. (2014). Protokoly provizora (farmatsevta) [Protocols of Provisor (Pharmacist)]. Kharkiv: NUPh: Golden Pages [in Ukrainian].

Zupanets, I.A., Popov, S.B., & Rudyk, Yu.S. (2021). Cymptomy ta syndromy v praktychnii farmatsii. Pryntsypy terapii: navch. posib. dlia studentiv vyshch. navch. zakl. [Symptoms and syndromes in practical pharmacy. Principles of therapy: teach. manual. for students of higher. edu. est.]. Kharkiv: NUPh: Golden Pages [in Ukrainian].

Kukes, V.G. (1999). Fitoterapiya s osnovami klinicheskoy farmakologii [Herbal medicine with the basics of clinical pharmacology]. Moskva: Medicine [in Russian].

Khronichnyi kashel u ditei: nastanova 00617 [Chronic cough in childs: instruction 00617]. Retrieved from: https://guidelines.moz.gov.ua [in Ukrainian].

Khronichnyi kashel u doroslykh: nastanova 00115 [Chronic cough in adults: instruction 00115]. Retrieved from: https://guidelines.moz. gov.ua [in Ukrainian].

(2015). Acute bronchitis. Phytotherapy instead of antibiotic: proactive communication! MMW Fortschr. Med., 19, 157(1), 66-67. Retrieved from: https://www.ncbi. nlm.nih.gov/pubmed/25767867. 49.

(2013). Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010. Infect. Control. Hosp. Epidemiol., , 34(1), 1-14. DOI: 10.1086/668770.

Seibel, J., Pergola, C., Werz, O., Kryshen, K., Wosikowski, K., Lehner, M.D., & Haunschild, J. (2015). Bronchipret® syrup containing thyme and ivy extracts suppresses bronchoalveolar infl ammation and goblet cell hyperplasia in experimental bronchoalveolitis. Phytomedicine, 1, 22 (13). DOI: 10.1016/j.phymed.2015.09.001.

Chevallier, A. (2016). Encyclopedia of herbal medicine. US: Dorling Kindersley.

Hubert, M. (2015). It need not always be an antibiotic. MMW Fortschr. Med. 19, 157(3), 67. DOI: 10.1007/s15006–015–2707–0.

Landa, P., Kokoska, L., Pribylova, M., Vanek, T., & Marsik, P. (2009). In vitro anti-inflammatory activity of carvacrol: inhibitory eff ect on COX-2 catalyzed prostaglandin E(2) biosynthesis. Arch. Pharm. Res., 32(1), 75-78. DOI: 10.1007/s12272-009-1120-6.

Kardos, P. (2015). Phytotherapy in acute bronchitis: what is the evidence? Clinical Phytoscience, 1, 2. DOI: 10.1186/s40816–015–0003–2.

Nagoor Meeran, M.F., Javed, H., Al Taee, H., Azimullah, S., & Ojha, S.K. (2017). Pharmacological properties and molecular mechanisms of thymol: prospects for its therapeutic potential and pharmaceutical development. Front. Pharmacol., 26, 8, 380. DOI: 10.3389/ fphar.2017.00380.

Pulia, M., Redwood, R., & May, L. (2018). Antimicrobial Stewardship in the Emergency Department. Emerg. Med. Clin. North Am., 36(4), 853-872. DOI: 10.1016/j.emc.2018.06.012.

Saust, L.T., Bjerrum, L., Siersma, V., Arpi, M., & Hansen, M.P. (2018). Quality assessment in general practice: diagnosis and antibiotic treatment of acute respiratory tract infections. Scand. J. Prim. Health Care., 36(4), 372-379. DOI: 10.1080/02813432.2018.1523996.

Tanner, M., & Karen Roddis. J. (2018). Antibiotics for acute bronchitis. Nurs. Stand., 28, 32(27), 41-43. DOI: 10.7748/ns.2018.e11123.

Wienkötter, N., Begrow, F., Kinzinger, U., Schierstedt, D., & Verspohl, E.J. (2007). The effect of thyme extract on beta2-receptors and mucociliary clearance. Planta Med., 73(7), 629-635. DOI: 10.1055/s-2007-981535.

Published

2022-06-08

How to Cite

Zupanets, K. O., Sakharova, T. S., Otrishko, I. A., Bezugla, N. P., Shebeko, S. K., Ratushna, K. L., … Propisnova, V. V. (2022). MODERN APPROACHES FOR THE TREATMENT OF COUGH: CLINICAL AND PHARMACOLOGICAL ASPECTS. Achievements of Clinical and Experimental Medicine, (1), 7–18. https://doi.org/10.11603/1811-2471.2022.v.i1.12982

Issue

Section

Огляд літератури