EPIDEMIOLOGICAL FEATURES OF HEREDITARY MOTOR AND SENSORY NEUROPATHY DISTRIBUTION IN THE POLTAVA REGION
DOI:
https://doi.org/10.11603/1811-2471.2021.v.i3.12394Keywords:
hereditary motor sensory neuropathy, Poltava region, epidemiologyAbstract
Hereditary motor and sensory neuropathy (HMSN) is a group of clinically and genetically heterogeneous neuropathic disorders that are common throughout the world and encompass all ethnic groups. The prevalence of HMSN is unevenly distributed across regions. The study of the territorial and ethnic distribution of HMSN in the Poltava region was not carried out.
The aim – to study the epidemiological features of HMSN in the Poltava region in the context of administrative and territorial units and individual ethnic groups of the population.
Material and Methods. To study the epidemiological features of the distribution of HMSN in the Poltava region, the prevalence rate of hereditary motor-sensory neuropathy was calculated both for various administrative and territorial units of the Poltava region and for individual ethnic groups of the population.
Results. The prevalence rate of all forms of HMSN in the Poltava region is 5.1. The high values of the prevalence of HMSN in certain districts of the Poltava region is associated with the presence of a dominant type of inheritance and large families. In the Poltava region, the proportion of patients with HMSN among the urban population was higher (64.9 %) than among residents of country areas (35.1 %). It was also revealed that the highest prevalence rates of HMSN were observed in areas bordering with neighboring regions.
Conclusions. The prevalence rate of all forms of HMSN in the Poltava region is unevenly distributed. The accumulation of individual forms of HMSN in the border zones reflects the influence of migrations on the formation of the structure of the gene pool and the burden of hereditary pathology of the population of the Poltava region.
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