РОЛЬ CD МАРКЕРОВ В РАЗВИТИИ ВОСПАЛЕНИЯ УВЕАЛЬНОГО ТРАКТА
DOI:
https://doi.org/10.11603/1811-2471.2021.v.i2.12209Keywords:
neutrophilsAbstract
It is great interest to identify general and specific disorders of systemic of T-cell immunity and phagocytic immunity in the pathogenesis of uveitis. On the surface of all immune cells there is a huge amount of proteins – CD markers. Determination of CD markers is useful for both diagnosis and treatment of different diseases. There is poor information about specific CD markers in inflammation of the uveal tract in the literature.
The aim – to evaluate the expression level of the neutrophil activation marker CD15 and the apoptosis marker CD95 in patients with intermediate uveitis.
Material and Methods. The study involved 26 apparently healthy individuals and 26 patients with intermediate uveitis, in 15 of which the level of expression of the marker of apoptosis of lymphocytes CD15 (group I) and in 11 – the level of expression of the marker of activation of neutrophils CD95 in the peripheral blood were studied.
Results. A high level of expression of the molecular marker of apoptosis CD95 was found in patients with intermediate uveitis. This indicator was – 28.5±4.9 % that was 534.2±59.5 cells/μl, (n=15). At the same time, in healthy individuals these parameters were 18.9±3.1 % and 254.5±42.1 cells/μL, respectively, (n=26), (p<0.05 according to the Mann-Whitney test). Also, a high level of expression of the CD15 marker was established, namely, 28.7±5.8 %, that was 980.19± 58.4 cells/μL (n=11). At the same time, in healthy individuals these parameters were 14.2±3.1 % and 165.5±32.1 cells/μL, (n=26), (p<0.05 according to the Mann-Whitney test).
Conclusions. In summary, the assessment of the subpopulations of lymphocytes and the functional activity of peripheral blood neutrophils in uveitis of various etiologies is extremely necessary because of the necessity of fundamental study of the pathogenesis of inflammation, and also of finding effective methods of treatment and immune correction of this pathology. Our findings and previous literature data lead us to the hypothesis that apoptosis of lymphocytes may lead to the resolution of uveitis, but neutrophils may be responsible for tissue damage. And immune correction, as suppression of the effect of neutrophils, may have therapeutic value. But these assumptions certainly warrant further study.
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