FEATURES OF THE OCCURRENCE AND PASSING OF RECURRENT DEPRESSIVE DISORDER: CURRENT STATUS
(OVERVIEW)
DOI:
https://doi.org/10.11603/1811-2471.2021.v.i2.12196Keywords:
recurrent depressive disorder, antidepressants, neurophysiological factors, genetic factors of depression, inflammatory biomarkers in depressionAbstract
Today recurrent depressive disorder is considered as a complex biological phenomenon involving dysregulation of neuroendocrine immunological processes, with a clear hereditary predisposition, where genetic factors play a significant role in the formation, development and clinical manifestations of depressive states.
The aim – to investigate the current view on the occurrence and clinical manifestations of recurrent depressive disorder.
Material and Methods. Databases PubMed, MedLine, EMBASE, CINAHL, PsycINFO were used. The search included publications until 2019. The studies were included provided that they met all of the following criteria: studies over the past five years, which aimed to identify risk factors for depressive disorder, factors that may complicate the course of MDD and diagnostic methods.
Results. The results of recent studies provide a better understanding of the genetic and neurophysiological architecture of this disease, as well as pave the way for further research into the biological mechanisms of depression, which can become therapeutic targets for potentially fundamentally new antidepressants. The importance of early development of the nervous system as a risk factor for mental disorders is becoming increasingly apparent. Despite the evidence for a link between perinatal depression and an increase in the development of psychopathology in offspring, many factors can mitigate or, conversely, worsen the effects of depression in the mother. These factors affect the fetus from early pregnancy to early life, with a wide range of consequences. Some of the most studied are such as genetics, maternal abuse and the use of antidepressants during pregnancy. As well as other less studied factors - such as the role of the father, eating habits and the impact of the duration and severity of mental problems of parents on the child.
Conclusions. Despite the availability of encouraging research results, including genetic and epigenetic, gene expression studies, a combination of biomarkers in the blood, neurocognitive and neuroimaging studies, this area needs further study.
References
Luking, K.R., Nelson, B.D., Infantolino, Z.P., Sauder, C.L., & Hajcak, G. (2018). Ventral Striatal Function Interacts With Positive and Negative Life Events to Predict Concurrent Youth Depressive Symptoms. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3 (11), 937-946. doi:10.1016/j.bpsc.2018.07.007
Sawyer, K.M., Zunszain, P.A., & Dazzan, P. (2019) Intergenerational transmission of depression: clinical observations and molecular mechanisms. Mol. Psychiatry 24, 1157–1177 doi:10.1038/s41380-018-0265-4
Biaggi, A., Conroy, S., Pawlby, S., & Pariante, C M. (2016). Identifying the women at risk of antenatal anxiety and depression: A systematic review. Journal of Affective Disorders, 191, 62-77. doi:10.1016/j.jad.2015.11.014
Odonnell, K. J., Glover, V., Barker, E. D., & Oconnor, T. G. (2017). The persisting effect of maternal mood in pregnancy on childhood psychopathology. Development and Psychopathology, 26 (2), 393-403. doi:10.1017/s0954579414000029
Plant, D.T., Pariante, C.M., Sharp, D., & Pawlby, S. (2015). Maternal depression during pregnancy and offspring depression in adulthood: Role of child maltreatment. British Journal of Psychiatry, 207 (3), 213-220. doi:10.1192/bjp.bp.114.156620
Capron, L.E., Glover, V., Pearson, R.M., Evans, J., O’Connor, T.G., Stein, A., & Ramchandani, P.G. (2015). Associations of maternal and paternal antenatal mood with offspring anxiety disorder at age 18 years. Journal of Affective Disorders, 187, 20-26. doi:10.1016/j.jad.2015.08.012
Munhoz, T.N., Santos, I.S., Barros, A.J., Anselmi, L., Barros, F.C., & Matijasevich, A. (2017). Perinatal and postnatal risk factors for disruptive mood dysregulation disorder at age 11: 2004 Pelotas Birth Cohort Study. Journal of Affective Disorders, 215, 263-268. doi:10.1016/j.jad.2017.03.040
Jarde, A., Morais, M., Kingston, D., Giallo, R., Macqueen, G.M., Giglia, L., & Mcdonald, S.D. (2016). Neonatal Outcomes in Women With Untreated Antenatal Depression Compared With Women Without Depression. JAMA Psychiatry, 73 (8), 826. doi:10.1001/jamapsychiatry.2016.0934
O’Donnell, K.J., & Meaney, M.J. (2017). Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis. American Journal of Psychiatry, 174 (4), 319-328. doi:10.1176/appi.ajp.2016.16020138
Couto, T.C., Brancaglion M.Y.M. , Alvim-Soares A., Moreira L., & Garcia F.D. (2015). Postpartum depression: A systematic review of the genetics involved. World Journal of Psychiatry, 5 (1), 103. doi:10.5498/wjp.v5.i1.103
Viktorin, A., Meltzer-Brody, S., Kuja-Halkola, R., Sullivan, P.F., Landén, M., Lichtenstein, P., & Magnusson, P.K. (2016). Heritability of Perinatal Depression and Genetic Overlap With Nonperinatal Depression. American Journal of Psychiatry, 173 (2), 158-165. doi:10.1176/appi.ajp.2015.15010085
Wazana, A., Moss, E., Jolicoeur-Martineau, A., Graffi, J., Tsabari, G., Lecompte, V., & Meaney, M.J. (2015). The interplay of birth weight, dopamine receptor D4 gene (DRD4), and early maternal care in the prediction of disorganized attachment at 36 months of age. Development and Psychopathology, 27 (1), 1145-1161. doi:10.1017/s0954579415000735
Qiu, A., Shen, M., Buss, C., Chong, Y., Kwek, K., Saw, S., & Meaney, M.J. (2017). Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk. Cerebral. Cortex, 27 (5), 3080-3092. doi:10.1093/cercor/bhx065
Silveira, P.P., Pokhvisneva, I., Parent, C., Cai, S., Rema, A.S., Broekman, B.F., & Meaney, M.J. (2017). Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression. Development and Psychopathology, 29 (5), 1601-1617. doi:10.1017/s0954579417001262
Belsky, J., Pokhvisneva, I., Rema, A.S., Broekman, B.F., Pluess, M., Odonnell, K.J., & Silveira, P.P. (2018). Polygenic differential susceptibility to prenatal adversity. Development and Psychopathology, 31 (02), 439-441. doi:10.1017/s0954579418000378
Cattaneo, A., Cattane, N., Malpighi, C., Czamara, D., Suarez, A., Mariani, N., & Pariante, C.M. (2018). FoxO1, A2M, and TGF-β1: Three novel genes predicting depression in gene X environment interactions are identified using cross-species and cross-tissues transcriptomic and miRNomic analyses. Molecular Psychiatry, 23 (11), 2192-2208. doi:10.1038/s41380-017-0002-4
Paulzen, M., Goecke, T.W., Stickeler, E., Gründer, G., & Schoretsanitis, G. (2017). Sertraline in pregnancy – Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood. Journal of Affective Disorders, 212, 1-6. doi:10.1016/j.jad.2017.01.019
Mcallister-Williams, R.H., Baldwin, D.S., Cantwell, R., Easter, A., Gilvarry, E., Glover, V., & Young, A.H. (2017). British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017. Journal of Psychopharmacology, 31 (5), 519-552. doi:10.1177/ 0269881117699361
Pariante, C.M. (2016). Depression and Antidepressants in Pregnancy: Molecular and Psychosocial Mechanisms Affecting Offspring’s Physical And Mental Health. Neuropsychopharmacology, 40 (1), 246-247. doi:10.1038/npp.2014.219
Ornoy, A. (2017). Neurobehavioral risks of SSRIs in pregnancy: Comparing human and animal data. Reproductive Toxicology, 72, 191-200. doi:10.1016/j.reprotox.2017.05.003
Latendresse, G., Elmore, C., & Deneris, A. (2017). Selective Serotonin Reuptake Inhibitors as First-Line Antidepressant Therapy for Perinatal Depression. Journal of Midwifery & Womens Health, 62 (3), 317-328. doi:10.1111/jmwh.12607
Newman, L., Judd, F., Olsson, C.A., Castle, D., Bousman, C., Sheehan, P., & Everall, I. (2016). Early origins of mental disorder - risk factors in the perinatal and infant period. BMC Psychiatry, 16 (1). doi:10.1186/s12888-016-0982-7
Bowers, M.E., & Yehuda, R. (2015). Intergenerational Transmission of Stress in Humans. Neuropsychopharmacology, 41 (1), 232-244. doi:10.1038/npp.2015.247
Sureshchandra, S., Wilson, R.M., Rais, M., Marshall, N.E., Purnell, J.Q., Thornburg, K.L., & Messaoudi, I. (2017). Maternal Pregravid Obesity Remodels the DNA Methylation Landscape of Cord Blood Monocytes Disrupting Their Inflammatory Program. The Journal of Immunology, 19 (8), 2729-2744. https://doi.org/10.4049/jimmunol.1700434
van Otterdijk, S.D., Binder, A.M., & Michels, K.B. (2017). Locus-specific DNA methylation in the placenta is associated with levels of pro-inflammatory proteins in cord blood and they are both independently affected by maternal smoking during pregnancy. Epigenetics, 12 (10), 875-885. https://doi.org/10.1080/15592294.2017.1361592
Toth, M. (2015). Mechanisms of Non-Genetic Inheritance and Psychiatric Disorders. Neuropsychopharmacology, 40 (1), 129-140. https://doi.org/10.1038/npp.2014.127
Glover, V. (2017). Prenatal stress and its effects on the neurodevelopment of the fetus and the child: the mediating role of the placenta. Placenta, 57, 232. https://doi.org/10.1016/j.placenta.2017.07.041.
Turecki, G., & Meaney, M.J. (2016). Effects of the Social Environment and Stress on Glucocorticoid Receptor Gene Methylation: A Systematic Review. Biological Psychiatry, 79 (2), 87-96. https://doi.org/10.1016/j.biopsych.2014.11.022
Smart, C., Strathdee, G., Watson, S., Murgatroyd, C., & McAllister-Williams, R.H. (2015). Early life trauma, depression and the glucocorticoid receptor gene – an epigenetic perspective. Psychological Medicine, 45 (16), 3393-3410. https://doi.org/10.1017/s0033291715001555
Seth, S., Lewis, A., Saffery, R., Lappas, M., & Galbally, M. (2015). Maternal Prenatal Mental Health and Placental 11β-HSD2 Gene Expression: Initial Findings from the Mercy Pregnancy and Emotional Wellbeing Study. International Journal of Molecular Sciences, 16 (11), 27482-27496. https://doi.org/10.3390/ijms161126034
Mikelson, C., Kovach, M., Troisi, J., Symes, S., Adair, D., Miller, R., Salafia, C., Johnson, K., Lin, Z., & Richards, S. (2015). Placental 11β-Hydroxysteroid dehydrogenase type 2 expression: Correlations with birth weight and placental metal concentrations. Placenta, 36 (11), 1212-1217. https://doi.org/10.1016/j.placenta.2015.09.011
Osborne, S., Biaggi, A., Chua, T., Du Preez, A., Hazelgrove, K., Nikkheslat, N., Previti, G., Zunszain, P., Conroy, S., & Pariante, C. (2018). Antenatal depression programs cortisol stress reactivity in offspring through increased maternal inflammation and cortisol in pregnancy: The Psychiatry Research and Motherhood – Depression (PRAM-D) Study. Psychoneuroendocrinology, 98, 211-221. https://doi.org/10.1016/j.psyneuen.2018.06.017
Mah, B.L., Bakermans-Kranenburg, M.J., Van Jzendoorn, M.H., & Smith, R. (2017). Oxytocin promotes protective behavior in depressed mothers: a pilot study with the enthusiastic stranger paradigm. Depression and Anxiety, 32 (2), 76-81. https://doi.org/10.1002/da.22245
Kroll-Desrosiers, A.R., Nephew, B.C., Babb, J.A., Guilarte-Walker, Y., Moore Simas, T.A., & Deligiannidis, K.M. (2017). Association of peripartum synthetic oxytocin administration and depressive and anxiety disorders within the first postpartum year. Depression and Anxiety, 34 (2), 137-146. https://doi.org/10.1002/da.22599
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Achievements of Clinical and Experimental Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
