EVALUATION OF EFFECTIVENESS OF METABOLIC THERAPY IN THE DEVELOPMENT OF ADHESIVE DYSFUNCTION OF ENDOTHELIA IN PATIENTS WITH ARTERIAL HYPERTENSION

Abstract

Еndothelial dysfunction is considered a predictor of high risk of cardiovascular disease. Additional use of metabolic therapy in the complex treatment of patients with hypertension affects the stabilization of endothelial dysfunction, which prevents the occurrence and progression of complications.

The aim – to evaluate the effectiveness of metabolic therapy to change the indicators of adhesive dysfunction of the endothelium in patients with hypertension (AH).

Material and Methods. The results of the concentration of vascular endothelial adhesion molecules (s-VCAM), type I intercellular adhesion molecules (s-ICAM-1), as well as the level of endothelin-1 in the serum of patients with stage II hypertension of 2–3 degrees are presented. 65 patients (32 men and 33 women) were examined. The mean age of patients was 45.2±10.5 years. Patients with hypertension received basic combination antihypertensive therapy ramipril / amlodipine in individually selected doses, in combination with metabolic therapy – quercetin.

Results. The use of metabolic therapy in patients with hypertension helps to reduce the concentration of soluble forms of adhesive molecules of the vascular endothelium (s-ICAM-1, sVCAM), endothelin-1 levels, reduces endothelial dysfunction and reduces the development and progression of complications in patients.

Conclusions. Violation of endothelium-dependent vasodilation in patients with hypertension is associated with a significant increase in the number of soluble adhesion molecules: sVCAM and ICAM-1 in the serum, as well as an increase in the concentration of endothelin-1. The use of quercetin (corvetin, quertin) in combination therapy with the combined antihypertensive drug ramipril / amlodipine affects the stabilization of endothelial dysfunction.