EVALUATION OF VITAMIN D LEVEL AND IODINE STATUS IN PREMENOPAUSAL WOMEN WITH AUTOIMMUNE THYROID DISEASE
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i4.11770Keywords:
ioduria, iodine deficiencyAbstract
SUMMARY. Vitamin D deficiency and insufficient iodine supply were observed in premenopausal women with hypothyroidism of autoimmune origin.
The aim – to determine the level of vitamin 25 (OH) D3 and to assess the median ioduria in premenopausal women with autoimmune hypothyroidism.
Material and Methods. 146 premenopausal women with autoimmune hypothyroidism were examined. To assess the functional state of the thyroid gland, the level of thyroid-stimulating hormone, free thyroxine, free triiodothyronine and the level of antibodies to thyroperoxidase and antibodies to thyroglobulin were determined. Serum vitamin D levels were determined in the autumn-winter period and iodine supply was assessed by the concentration of iodine in single portions of urine.
Results and Discussion. 78.8 % of premenopausal women with autoimmune hypothyroidism had deficiency of vitamin D and 17.1 % had insufficiency of vitamin D. The results of determining the median of ioduria showed insufficient iodine supply in 48.9 % of patients (mild iodine deficiency in 26.7 % and moderate severity in 22.2 %) and excessive iodine suply in 8.9 % of patients. Significantly strong negative correlations were found between 25 (OH) D and the level of antibody to thyroperoxidase and thyroid-stimulating hormone and a medium positive correlation with the level of free thyroxine and free triiodothyronine (p<0.05). Correlation analysis revealed positive relationships of the mean strength between the level of median iodine excretion with the level of thyroid-stimulating hormone and the level of antibodies to thyroperoxidase (p<0,05).
Conclusion. Vitamin D deficiency correlates with decreased thyroid function and the severity of hypothyroidism, which determines the need for additional prescription of vitamin D for all premenopausal women with autoimmune hypothyroidism. To control the iodine status of women with autoimmune hypothyroidism, it is necessary to monitor thyroid function and iodine concentration in the body.
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