THE EFFECT OF DRUG THERAPY IN PATIENTS WITH OBESITY ON THE CLINICAL MANIFESTATIONS OF KNEE OSTEOARTHRITIS
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i1.11085Keywords:
osteoarthritis, overweight patients, orlistatAbstract
The effect of orlistat therapy on the clinical manifestations of osteoarthrosis (OA) of the knee joints in patients suffering from obesity at the site of a general practitioner is considered in the article.
The aim – assessment of the effect of weight loss on the background of orlistat administration on clinical manifestations of OA of knee joints in women with overweight.
Material and Methods. The study involved 5 general practitioners and 50 patients with symptomatic OA that met the criteria of the American College of Rheumatologists (ACR).
The WOMAC questionnaire was used to determine the effectiveness of the therapy. The evaluation was performed by VAS in millimeters. Quality of life (patient health) was determined by VAS questionnaire EQ-5D. Patients were evaluated for adverse reactions during the observation period. Data processing was performed using descriptive statistics methods.
Results. Orlistat obesity therapy has the potential to achieve clinically significant reductions (≥5 %). Weight loss when taking special drugs in patients with obesity and OA of the knee joints is accompanied by a decrease in pain and improvement in the functional state of knee joints, which has a positive effect on the quality of life of patients.
Conclusions. Weight loss, in patients with high body mass index and OA of the knee joints, especially when taking drugs that contribute to its reduction, leads to regression of clinical manifestations of gonarthrosis: reducing pain and improving functional status. In this regard, drugs that contribute to weight loss, should be included in the scheme of treatment of patients with OA and obesity.
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