COMPARATIVE CHARACTERISTICS OF IMMUNE STATUS IN DIFFERENT TYPES OF COURSE IN PATIENTS WITH SPORADIC AND FAMILIAL FORMS OF MULTIPLE SCLEROSIS
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i1.11069Keywords:
multiple sclerosis, immune indicators, cellular and humoral immunity, mathematical analysisAbstract
In recent decades, the leading role of immunopathological disorders in the pathogenesis of multiple sclerosis (MS) has been conclusively proven. However, the complex and ambiguous nature of clinical and immunological relationships in different types of MS, given the hereditary burden of this disease, need further study.
Material and Methods. An analysis of 197 immunograms was performed in patients with different types of MS course with sporadic and familial forms: 110 – in patients with sporadic and 27 – with familial forms in a relapsing course (RC); 41 – with sporadic and 19 – with familial forms with progressive types of course (PC) of MS. To determine the cellular and humoral immunity links in blood serum, 16 indicators were studied within the normative values, above and below the norm.
Results. The analysis showed that in two forms with RT, a pronounced deficiency of the regulatory cell link (CD4 and CD8) and an increased content of lymphocytotoxic autoantibodies (p<0.05) were found. In the family form of RT, the number of studies with an increase in IgM and complement significantly combined with leukopenia and B-lymphocytosis (p<0.05). With PC RS for the sporadic form, complement, immune complexes and lymphocytotoxic autoantibodies were significantly increased. With help of mathematical (permutation method) and statistical (contingency tables) analyzes, were obtained the following: reliable numerical differences between the forms; the average number of deviations from the norm for all immunological indicators; connections between pairs of characters according to the chi-square criterion with enumeration of all possible pairs of 16 immunological indicators.
As a result of researches, significant differences were obtained in the structural organization of the immune imbalance for sporadic and familial forms of MS, that selectively affected both the cellular and humoral components of immunity, as well as the integral indicators obtained using mathematical methods.
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