MYOCARDIAL CONTRACTILE FUNCTION AND CEREBRAL BLOOD FLOW INDICES DYNAMICS IN HYPERTENSIVE OVERWEIGHT PATIENTS AFTER THERAPY BY ANTIHYPERTENSIVES COMBINED WITH STATINS
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i1.10937Keywords:
systolic function, diastolic function, linear blood flow velocities, arterial hypertension, overweight patientsAbstract
The aim of the work was to assess the dynamics of systolic, diastolic function and remodeling of the left ventricle of the myocardium, linear blood flow velocities in the basins of the common carotid artery, internal carotid artery, external carotid artery, middle cerebral artery, vertebral artery (V2) in male and female patients with hypertension II stage and overweight under the influence of combination therapy with antihypertensive drugs and rosuvastatin.
Material and Methods. In 64 patients, the average age is 59.0 [48.0; 63.0] years, with stage II hypertension and overweight, the dynamics of systolic, diastolic function and remodeling of the left ventricle, linear blood flow velocities in the basins of the common carotid artery, internal carotid artery, external carotid artery, middle cerebral artery, vertebral artery under the influence of combination therapy were evaluated (fixed combinations of antihypertensive drugs – the equator (amlodipine 5 mg and lisinopril 10 mg) and valodip (amlodipine 5 mg and valsartan 80 mg) for 120 days), which includes rosuvastatin 10 mg per day.
Results. All patients underwent a general clinical, laboratory and instrumental examination in order to verify the diagnosis, identify complications and associated pathology. During treatment, an improvement in left ventricular contractility, its reverse remodeling, and an increase in systolic ejection power are observed. Indicators of diastolic function of the left ventricle after treatment indicate an improvement in the processes of relaxation of the left ventricle, its compliance and contractility of the left atrium during therapy, a decrease in left ventricular hypertrophy and a decrease in the risk of cardiovascular complications. A significant decrease in the diameters of the examined cerebral arteries (CommonAAA, ICA, ExternalCMA and PAA) against the background of the antihypertensive and antilipidemic therapy indicates an inverse structural and functional remodeling of the cerebral vessels – a decrease in thickness and increased elasticity of the vascular wall.
Conclusions. The improvement in the elastic properties of SMA as a result of the therapy indicates a significant reduction in cardiovascular risk, in particular, the risk of stroke. Thus, there is an improvement in cerebral circulation and cerebral trophism, which indicates the adequacy and feasibility of selected regular antihypertensive and anti-lipidemic therapy.
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