INFLUENCE OF POLYTRAUMA ON HISTOFUNCTIONAL CHANGES IN MYOCARDIAL TISSUES IN DYNAMICS OF A POSTTRUMATIC PERIOD IN A COMBINED TRAUMA IN THE EXPERIMENT IN THE FIELD OF HYPOKINETIC OSTEOPOROSIS
DOI:
https://doi.org/10.11603/1811-2471.2019.v.i4.10811Keywords:
polytrauma, hypokinetic osteoporosis, myocardium, regeneration, cardiomyocytesAbstract
In the 21st century, problem of assisting victims with combined trauma has become particularly relevant, since it is the effect of mechanical trauma that are the main cause of mortality in young and able-bodied people. The pathomorfological researches shown that severe combined trauma has a biggest influence on the functioning of all internal organs and systems.
The aim of the work – to study the effect of polytrauma on structural changes in myocardial tissues in the post-traumatic period in animals with hypokinetic osteoporosis.
Material and Methods. Experiments were performed on 42 non-linear white male rats weighing 200–220 g. In the first series of experiments in animals, hypokinetic osteoporosis was induced by the method of Z. Kundurovich, after 2 months of modeling a polytrauma. In the second series, animals without osteoporosis were similarly injured. Animals were extracted from the experiment for 10, 20 and 30 days. For histological examination, the tissues of the myocardium were removed, their structure was studied normally, as well as the nature and depth of morphological changes after the simulated polytrauma.
Results. At the 10th day of the experiment in animals without osteoporosis changes in the myocardium were manifested by circulatory disorders and focal degenerative changes. At the 20th day of the experiment in animals without osteoporosis, the same changes were observed as in the 10th day. At the 10th day after the polytrauma in animals with hypokinetic osteoporosis in the myocardium, minor circulatory disorders and focal degenerative changes also occurred. As in the group of animals without osteoporosis, in the 20th day of experiment in animals with osteoporosis, significant changes in the myocardium were not observed in comparison with the 10th. In the 30th day, in animals without osteoporosis, inflammatory-dystrophic changes tended to decrease. However, in animals with osteoporosis for 30 days in the myocardium, there are isolated dystrophic-necrotic changes of cardiomyocytes, swelling of the stroma with pronounced cellular infiltrates.
Conclusions. Polytrauma is accompanied by histological abnormalities in the myocardium, which are more pronounced in animals with hypokinetic osteoporosis in all terms of observation. On the 30th day in the myocardium, there are some changes that indicate the formation of pathogenic mechanisms of the secondary exacerbation of polytrauma under the influence of osteoporosis.
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