FEATURES OF THE COURSE OF ALCOHOLIC LIVER CIRRHOSIS COMORBID WITH CHRONIC PANCREATITIS
DOI:
https://doi.org/10.11603/1811-2471.2019.v.i3.10506Keywords:
alcoholic liver cirrhosis, chronic pancreatitis, lipid peroxidation, endotoxicosisAbstract
SUMMARY. Today, alcoholism, as the cause of mortality, is on the next place after cardiovascular diseases and malignant neoplasms. The liver and pancreas are especially affected as a result of chronic alcohol intoxication, so further studies of the characteristics of the combined alcoholic pathology of these organs are relevant.
The aim of the study – to learn the features of the combined course of alcoholic liver cirrhosis and chronic pancreatitis, taking into account changes in the state of free radical oxidation of lipids and endotoxemia.
Materials and Methods. The study included 166 patients with alcoholic liver cirrhosis, 141 of whom were diagnosed with chronic pancreatitis. The average age of the patients was (51.20±6.51) years, the duration of the disease was (2.8±1.8) years.
Results and Discussion. With the comorbid course of alcoholic liver cirrhosis and chronic pancreatitis, significant changes in the lipid peroxidation and antioxidant defense systems, and a pronounced endotoxicosis were revealed, their relationship with the main manifestations of cytolytic and mesenchymal inflammatory syndrome was confirmed.
Conclusions. The comorbid course of alcoholic liver cirrhosis and chronic pancreatitis enhances cytolysis and the inflammatory process, which in turn stimulates the processes of fibrotization of the liver tissue and the progression of pathological changes in the pancreatic tissue.
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