ALLERGIC MANIFESTATIONS IN CHRONIC PANCREATITIS (review of the problem)
(review of the problem)
DOI:
https://doi.org/10.11603/1811-2471.2019.v0.i2.10449Keywords:
chronic pancreatitis, allergy, urticaria, eczema, food intolerance, bronchospasmAbstract
Summary. Allergy was previously considered as condition that accompanies chronic pancreatitis, but does not have general mechanisms of development. But then it was found that such a mechanism is to break the cytokine link of immune defense and microcirculation. It was shown that prolonged circulatory disturbances can reduce the secretion of enzymes in software, and the disturbance of digestive processes, in turn, supports the ingestion of allergens in the body. That is, there is a certain correlation between allergic processes and pathogenesis of chronic pancreatitis.
The penetration of allergens can be via the inhalation route, parenterally or through the gastrointestinal tract. One of the essential factors is reactive dyskinetic and enzymatic disorders of the liver and biliary tract.
Allergic syndrome in chronic pancreatits is registered in 30 % of cases of manifestations of food, medical allergy (hives, eczema, allergic sinusitis). More often, CP is manifested by "eosinophilic" pancreatitis with an increase in eosinophils to 30–40 %.
Allocate symptoms that require attention of the physician and prove their value to patients. First, any red spots on the skin, itching after consuming a particular product, is an allergic reaction. Second, lowering blood pressure and tachycardia in this case should be perceived as an allergic reaction. Thirdly, itching in the rhino-oropharyngeal cavity and dry cough, bronchospasm is a negative sign of an allergic reaction in the prognostic plan.
Therefore, patients with chronic hepatitis C (especially with enzyme deficiency) are advised to undergo diagnosis of cellular and humoral immunity, diagnostics of foods that may cause food allergy, and must consult with dermatologists and allergists. If this is not possible, then it is necessary to exclude from the diet highly allergic products.
References
Gubergrits, N.B., & Kazyulyn, A.N. (2011). Metabolicheskaya pankreatologiya [Metabolic pancreatology]. Donetsk: OOO “Lebed“ [in Russian].
Gubergrits, N.B. Dyfferentsyalnaya diagnostika v gastroenterologii (ot symptoma i sindroma k diagnozu i lecheniyu): prakticheskoye rukovodstvo [Differential diagnosis in gastroenterology (from a symptom and syndrome to diagnosis and treatment)]. [in Russian].
Khrystych, T.M., & Hontsariuk, D.O. (2018). Etiolohichni faktory, shcho formuiut khronichnyi pankreatyt [Etiological factors forming chronic pancreatitis]. Zdobutky klinichnoi i eksperymentalnoi medytsyny – Achievements of Clinical and Experimenmtal Medicine, 3, 20-27 [in Ukrainian].
Kazyulin, A.N. Sovremennye predstavleniya ob etiologii khronicheskogo pankreatita [Modern perception about etiology of chronic pancreatitis]. Vestnyk kluba pankreatologov – Bulletin of Pancreatologists’ Club, 3 (32), 40 [in Russian].
Busse W., Sedgwick J.B, Jarjour N.N. Eosinophils and basophils in allergic airway inflammation. J. Allergy Clin. Immunol., 94, 1250-1254. DOI: https://doi.org/10.1016/0091-6749(94)90339-5
Nekrasova, L.O. (2005). Kozhnye proyavleniya vnutrennykh bolezney [Skin manifestations of internal diseases]. Nuvel estetik, 1, 90-100.
Inamura, H., Kashiwase, Y., & Morioka, J. (2005). Acute pancreatitis possibly caused by allergy to bananas. J. Investig. Allergol. Clin. Immunol., 15 (3), 222-224.
Pellegrino, K. (2012). Severe reaction in a child with asymptomatic codfish allergy: Food challenge reactivating recurrent pancreatitis. Ital. J. Pediatr., 38, 16. DOI: https://doi.org/10.1186/1824-7288-38-16
Subbotina, O.A., & Geppe, N.A. (2014). Mohut ly perekrestnye allergicheskiye reaktsii na pyshchevye antigeny byt prichynoy retsydiviruyushchego pankreatita u detey s pishchevoy allergiyey? [Can cross-allergic reactions to food antigens cause recurrent pancreatitis in children with food allergies?]. Voprosy pitaniya – Issues of Nutrition, 83 (1), 55-60 [in Russian].
