COMPARATIVE DI STINCTIONI S OF SPACE REORGANIZATION OF PLACENT IN WOMEN WITH FETU S LO SS SYNDROME WITHOUT CORRECTION AND ON THE BACKGROUND OF DRUG TREATMENT

Abstract

Fetal loss syndrome is a polyethyologic syndrome. In the genesis of reproductive losses, great importance is given to the inferior transformation of the endometrium and to the disturbance of trophoblast invasion processes. Study of changes in the placenta inherent in the fetal loss syndrome will allow to understand the pathogenesis of syndrome formation, to reveal the role of the vascular factor in the development of degenerative changes and to choose pathogenetically valid correction of the revealed disorders.

The aim of the study – to compare the macro and microscopic structure of the placenta of women with fetal loss syndrome without additional correction and against the background of the proposed medical treatment.

Materials and Methods. 100 placenta examination (group I formed 50 placenta of women who received medical therapy were performed, provided by the provisions of the clinical protocols of the Ministry of Health of Ukraine, group II – placenta mothers, who during the pregnancy additionally appointed a donor of nitric oxide and the drug of vitamin B9).

Results and Discussion. In the visual assessment and investigation of the histological structure of the placenta of the I group, we have been detected various pathological changes that are characteristic of the dystrophic-degenerative processes. In the second group placenta is noted reduction of pathological manifestations and activation of adaptive-compensatory processes.

Conclusions. Integrated therapy using a nitric oxide dopant and vitamin B9 helps to improve metabolic processes in the fetoplacental system.