IMMUNOLOGICAL ASPECTS OF GENERALIZED PERIODONTITIS (LITERATURE REVIEW)
DOI:
https://doi.org/10.11603/2415-8798.2018.2.9122Keywords:
generalized periodontitis, immunity, immunological parameters, somatic diseases.Abstract
The article presents the results of an analytical review of literature data in the field of assessing the state of immunological indicators in patients with generalized periodontitis. These data indicate a close relationship between the state of the human immune system and the development of generalized periodontitis against the background of concomitant somatic diseases. The influence of periodontopathogenic microorganisms on the immune response of a macroorganism is described. Data on the state of local and systemic immunity of patients with generalized periodontitis, abnormalities in antibody formation and the functioning of cellular defense mechanisms, activity and content of phagocytic cells, T-lymphocytes, natural killers, imbalance in the cytokine system in the gums and peripheral blood are presented. A number of authors note a significant role in the development of generalized periodontitis secondary immunodeficiency, allergic reactions and autoimmune processes, the general state of the adaptive mechanisms of the body. Disclosure or deepening of knowledge about the pathogenesis of generalized periodontitis will allow to construct optimal adequate therapy and offer effective prevention of dental disease.
References
Borisenko, A.V. (2013). Vplyv zakhvoriuvan parodonta na zahalniy stan organizmu [Influence of periodontal diseases on the general state of the organism]. Zdorovia suspilstva – Health of the society, 1, 32-37 [in Ukrainian].
Maschenko, I.S. Skidan, K.V. & Ryabokon, E.N. (2005). Diagnostika i korrektsiya narusheniy immunomikrobiotsenoza u bolnyih generalizovannyim parodontitom [Diagnostics and correction of immunomicrobiocenosis disorders in patients with generalized periodontitis]. Visnik stomatolohii – Bulletin of dentistry 1, 35-38 [in Ukrainian].
Beloklitskaya, G.F. (2000). Vozmozhnosti antioksidantnoy korrektsii perekisnogo okisleniya lipidov prizabolevaniyah parodonta raznoy tyazhesti [Opportunities of antioxidant correction of peroxidation of lipids in diseases of periodontitis of different gravity]. Sovremennaya stomatologiya – Modern dentistry,1, 38-41 [in Ukrainian].
Pavlenko, O.V., Golovnya, I.O. & Mazur, I.P (2005). Suchasni problemy stomatolohichnoho zdorovia naselennia Ukrainy [Modern problems of stomatological health of the population of Ukraine]. Zhurnal praktikuiuchoho likaria – Journal of the practitioner, 5, 8-3 [in Ukrainian].
Danilevskiy, N.F. & Muhin, T.A. (1993). Zabolevaniya parodonta: Atlas [Periodontal diseases: Atlas]. M. : Medicina, 320 [in Ukrainian].
Cepov, L.M. & Orekhova, L.Yu. (1999). Immunnaia patologiya vospalitelnyh zabolevanii parodonta: illyuziya ili realnost? [Immune pathology of inflammatory diseases periodontal: illusion or reality?] Parodontologiya – Periodontology, 2 (12), 3-9 [in Russian].
Antipova, I.N. (2008). Rol narushenii adaptacii v patogeneze vospalitelnyh zabolevanii parodonta u sportsmenov [The role of disorders of adaptation in the pathogenesis of inflammatory diseases of periodontal disease in athletes]: avtoreferat dissertacii doktora medicinskih nauk: 14.00.21 «Stomatologiya», Sankt-Peterburg, 36 [in Russian].
Orekhova, L.Yu., Bubnova, L.N., Glazanov, T.V. & Rozanov, N.N. (1999). Rol izmenenii v sisteme immuniteta pri zabolevaniyah tkanei parodonta [The role of changes in the immunity system in diseases of periodontal tissues]. Parodontologiya – Periodontology, 1, 27-29 [in Ukrainian].
Chumakova, Yu.G. (2002). Harakter izmenenii v sisteme mestnogo gumoralnogo immuniteta polos ti rta u bolnyh generalizovannym parodontitom razlichnoi stepeni tyazhesti [Character of changes in the system of local humoral immunity of oral bands in patients with generalized periodontitis of varying degrees of severity]. Vіsnik stomatologії − Vísnik dentistry, 4, 31-34 [in Ukrainian].
Chumakova, Yu.G. & Zaporozhec, N.N. (2002). Ocenka effektivnosti primeneniya preparata «Imudon» u bolnyh s vospalitelnymi zabolevaniyami parodonta [Evaluation of the effectiveness of the drug "Imudon" in patients with inflammatory diseases of the periodontal disease] Sovremennaya stomatologiya − Modern Dentistry. 3, 30-35 [in Ukrainian].
Borisenko, A.V. & Tkachenko, A.G. (2005). Stimulyaciya mestnyh zashchitnyh faktorov polosti rta v kompleksnom lechenii generalizovannogo parodontita s ispolzovaniem preparata «Imudon» [Stimulation of local protective factors of the cavity mouth in the complex treatment of generalized periodontitis using the preparation "Imudon"] Sovremennaya stomatologiya – Modern Dentistry, 3, 57-59 [in Ukrainian].
Hagewald. S., Bernimoulin, J.P. & Kottgen, E. (2000). Total IgA and Porphyromonas gingivalis – reactive IgA in the saliva of patients with generalized early-onset periodontitis. Eur. J. Oral. Sci., 108, 2, 147-153.
Shihnabaeva, Eh.D. (2007). Kliniko-immunologicheskoe obosnovanie kompleksnogo lecheniya parodonta sochetannogo s hronicheskoi obstruktivnoi boleznyu legkih, s primeneniem polioksidoniya [Clinical and immunological justification of complex treatment of periodontium combined with chronic obstructive pulmonary disease, with the use of polyoxidonium]: Extended abstract of candidate’s thesis. Sankt-Peterburg, p. 23 [in Russian].
Aznabaeva, Ye.D. (2005). Immuno-patogeneticheskie osobennosti razvitiya hronicheskogo generalizovannogo parodontita [Immunopathogenetic features of the development of chronic generalized periodontitis]. Fundamentalnye issledovaniya – Fundamental research. 6, 78-81 [in Russian].
Gumerova, M.I. (2006). Adaptacionnye mekhanizmy mestnogo immuniteta pri hronicheskih vospalitelnyh zabolevaniyah polosti rta i glotki [Adaptive mechanisms of local immunity with chronic inflammatory diseases of the oral cavity and pharynx]. Extended abstract of candidate’s thesis. Ufa, p. 22 [in Russian].
Pleshkova, L.V. (1986). Klinicheskie i ehnzimologicheskie pokazateli v dinamike vospalitelno-distroficheskogo processa v parodonte [Clinical and enzymological parameters in dynamics of the inflammatory-dystrophic process in the periodontium]. Extended abstract of candidate’s thesis. Moskva, 22 [in Russian].
Bulgakova, A.I. (2001). Vliyanie sostoyaniya mestnogo immuniteta desny i
rotovoi polosti na techenie hronicheskogo parodontita [Influence of the state of local gingiva immunity and of the oral cavity on the course of chronic periodontitis]. Novoe v stomatologii − New in dentistry, 10, 90-94 [in Russian].
Ivanyushko, T.P. (2000). Kompleksnoe izuchenie mekhanizmov razvitiya
hronicheskogo vospaleniya pri parodontite [Complex study of development mechanisms chronic inflammation in periodontitis]. Stomatologiya – Stomatology, 4, 13-16 [in Russian].
Sigusch, B., Eick, S. & Plister, W. (2001). Altered chemotactic behavior of crevicular PMNs in different forms of periodontitis J. Clin. Periodontal, 28, 2, 162-167.
Pupіn, T.І. & Shkrebnyuk, R.Yu. (2015). Poshirenіst heneralіzovanoho parodontytu v patsiientіv іz cukrovim dіabetom I typu na fonі dіabetichnoi kardіomіopatіi [Prevalence of generalized periodontitis in patients type I diabetes mellitus with diabetic cardiomyopathy]. Vіsnik naukovih doslіdzhen – Bulletin of scientific research 4, 65-67 [in Ukrainian].
Mashchenko, I.S. (2002). Interleikiny pri generalizovannom parodontite [Interleukins with generalized periodontitis]. Vіsnik stomatologії − Bulletin of dentistry, 1, 15-18 [in Ukrainian].
Zhiakonys, Y.M. (1986). Ymmunolohycheskye aspekty hynhyvyta y parodontyta [Immunological aspects of gingivitis and periodontitis]. Extended abstract of candidate’s thesis. Moskva, 24 [in Russian].
Ivanyushko, T.P., Bayariy, B. & Kovalchuk, L.V. (1989). Rehuliatsiia limfokinami fagotsitarnoy aktivnosti neytrofilov u bolnyih s vospalitelnymi zabolevaniyami parodonta [Regulation of lymphokines in phagocytic activity of neutrophils in patients with inflammatory periodontal diseases]. Stomatologiya − Stomatology. 6, 51-52 [in Russian].
Shmagel, K.V., Belyaeva, O.V. & Chereshnev, V.A. (2003). Sovremennyie vzglyady na immunologiyu parodontita [Modern views on the immunology of periodontitis]. Stomatologiya − Stomatology, 1, 61-64 [in Russian].
Yamamoto, M., Fujihashi, K., Hiroi, T., McGhee, J.R., Van Dyke, T.E. & Kiyono, H. (1997). Molecular and cellular mechanism for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. Periodontol., 32, 2, 115-119.
Lappin, D.F., Macleod, C.P., Kerr, A., Mitchell, T. & Kinane, D.F. (2001). Anti-inflammatory cytokine IL-10 and T-cell cytokine profile in periodontitis granulation tissue. Clinical & Experimental Immunology, 123, 2, 294-300.
Antipova, O.A., Mihalchenko, V.F. & Yakovlev, A.T. (2005). Immunnyi status bolnykh parodontitom [Immune status of patients with periodontitis]. Aktualnyye voprosy eksperimentalnoy, klinicheskoy i profilakticheskoy stomatologii – Actual questions experimental, clinical and preventive dentistry, 21-26 [in Russian].
Dereyko, L.V. (1987). Immunokorregiruyushchaya terapiya v kompleksnom lechenii bolnyih parodontitom [Immunocorrective therapy in an integrated treatment of patients with periodontitis]. Stomatologiya – Stomatology, 1, 32-33 [in Russian].
Maschenko, I.S. (1990). O razlichii v mekhanizmah razvitiya parodonta [ On the difference in the mechanisms of periodontal development] Stomatologiya – Stomatology, 1, 29-31 [in Russian].
Lappin, D.F., Koulouri, O., Radvar, M., Hodge, P., Kinane, D.F. (1999). Relative proportions of mononuclear cell types in periodontal lesions analyzed by immunohistochemistry. J. Clin. Periodontal, 26, 3, 183-189.
Segular, S., Godeau, G. & Brousse, N. (1995). Collagen fibers and inflammatory cell in healthy and diseased human gingival tissues: a comparative and quantitative study by immunohistochemistry and automated image analysis − J. Periodantol, 71, 7, 1079-1085.
Gamonal, J., Acevedo, A. & Boscones, A. (2000). Levels of interleukin-1 beta,-8, and -10 and RANTES in gingival crevicular fluid and cell population in adult periodontitis patients and the effect of periodontal treatment. J. Periodontol, 71, 10, 1535-1545.
Gurses, N., Unlu, F., Hekimgil, M. & Keskinoglu, A. (1996). Immunohistochemical characterization of lymphocyte subsets in chronic adult periodontitis. J. Nihon. Univ. Sch. Dent., 38, 2, 94-101.
Aramaki, M., Nagasawa, T., Koseki, T. & Ishikawa, I. (1998). Presence of activated B-1 cells in chronic inflamed gingival tissue. J. Clin. Immunolol, 18, 6, 421-429.
Pinelis, Yu.S., Malezhik, M.S. & Malezhik, L.P. (2010). Sostoyanie gumoralnyih sistem pri hronicheskom generalizovannom parodontite u lyudey pozhilogo vozrasta [The state of humoral systems in chronic generalized periodontitis in elderly people]. Bulletin health and education in the XXI century. − Vestnik zdorove i obrazovanie v XXI veke, 2, 91 [in Russian].
Maschenko, I.S., Kosenko, K.N. & Samoylenko, A.V. (2002). Etiotropnoe i patogeneticheskoe obosnovanie differentsirovannyih podhodov k terapii generalizovannogo parodontita [Etiotropic and pathogenetic substantiation of differentiated approaches to the therapy of generalized periodontitis]. Visnik stomatologiyi − Bulletin ofdDentistry, 4, 23-25 [in Ukrainian].
Morozov, V.G. (1992). Kompleksnaya terapiya generalizovannogo parodontita sredney i tyazheloy stepeni s primeneniem preparatov nizkomolekulyarnogo polivinilpirrolidona [Integrated therapy of generalized Periodontitis of moderate to severe degree with the use of drugs low molecular weight polyvinyl pyrrolidone]. Extended abstract of candidate’s thesis. Tver, 20 [in Russian].
Levin, M.Ya. & Orehova, L.Yu. (1996). Znachenie autoimmunnyh processov v patogeneze vospalitelnyh zabolevanii parodonta [The significance of autoimmune processes in pathogenesis inflammatory paralysis of periodontal disease]. Parodontologiya – Periodontology, 1, 19-26 [in Russian].
Cepov, L.M. & Nikolaev, A.I. (2001). Problemy zdorovya, normy, kachestva zhizni i patologii v stomatologii (obzor literatury) [Problems of health, norm, quality of life and pathology in dentistry (review of literature)]. Parodontologiya – Periodontology, 3, 25-29 [in Russian].
Wu.T., Trevisan, M., Falkner, K.L., Genco, R.J. & Dorn, J.P. (2000). Sempos CT. Examination of the relation between periodontal health status and cardiovascular risk factors: serum total and high-density lipoprotein cholesterol, Creactive protein, and plasma fibrinogen Am. S. Epidemiol, 151, 3, 273-282.
Fredriksson, M.I., Figueredo, C.M., Gustafsson, A., Bergström, K.G. & Asman, B.E. (1999). Effect of periodontitis and smoking on blood leukocytes and acute – hase proteins. J. Periodontol, 70, 11, 1355-1360.
Nisengard, R.J. & Blann, D.B (1985). Detection of immune complexes in gingival from periodontitis patients J. Dent. Res., 64, 361-365.
Firatli, E. & Uygur, C. (1999). Ditrybution of T-limphocyte in patients with generalized prepubertal periodontitis. J. Dent. Resp. Special tissue, 78, 3264.
Takahashi, K., Nagai, A., Satoh, N., Kurihara, H. & Murayama, Yo. (1995). Studies on the phenotypic and functional characterization of peripheral blood lymphocytes from patients with early-ruset periodontitis. S. Periodontol, 66, 5. 391-396.
Grudianov, A.I. & Bezrucova, I.V. (2000). The blood immunological indices in rapidly processing periodontitis (preminary results) Stomatologia, 79, 3, 15-17 [in Russian].
Mathur, A. & Michalowich B. C. (1997). Cell-mediated immune system regulation in periodontal diseases. Crit. Rev. Oral. Biol. Med, 8, 1, 76-89.
Kiseleva, E.A. (2001). Immunokorrekciya v kompleksnom lechenii I profilaktike hronicheskih vospalitelnyh i neoplasticheskih stomatologicheskih zabolevanij [Immunocorrection in complex treatment and prevention of chronic inflammatory and neoplastic dental diseases]. Kemerovo: KemGMA, 169 [in Russian].
Nagasava, T., Nitta, H., Watanabe, H. & Ishikawa, I. (1995). Reduced CD8+ peripheral blood T-lymphocytes in rapidly progressive periodontitis. Arch. Oral. Biol., 40, 7, 605-608.
Askerova, S.M. (2005). Lechenie hronicheskogo generalizovannogo parodontita srednei tyazhesti s primeneniem immunomodulyatora polioksidoniya. Candidate’s thesis. Moskva. 137 [in Russian].
Aren, G., Curel, N., Yalçin, F. & Firatli, E. (2003). Clinical and immunological findings of two siblings in a family with generalized aggressive periodontitis. J. Dent. Child. (Chic), 70, 3, 266-271.
Petit, M.D., Hovenkamp, E., Hamann, D., Roos, M.T., van der Velden, U., Miedema, F. & Loos, B.G. (2001). Phenotypical and functional analysis of T-cell in periodontitis J. Periodontal. Res, 36, 4, 214-220.
Kobayashi, H., Nagasawa, T., Aramaki, M., Mahanonda, R. & Ishikawa, I. (2000). Individual diversities in interferon gamma production by human peripheral blood mononuclear cells stimulated with periodontopathic bacteria. J. Periodontаl. Res., 35, 6, 319-328.
Bártová, J., Krátká-Opatrná, Z. & Procházková, J. (2000). Th1 and Th2 cytokine profile in patients with early onset periodontitis and their healthy siblings. Mediat. Inflam, 9, 2, 115-120.
Gudaryan, A.A. (2007). Citokinovyi status u bolnyh generalizovanym parodontitom pri saharnom diabete II tipa [Cytokine status in patients with generalized periodontitis in type II diabetes mellitus] Ukrayinskij stomatolologichnij almanah – Ukrainian stomatologic almanac, 3, 24-29 [in Ukrainian].
Mashenko, I.S. (2004). Obmen citokinov u bolnyh generalizovannym
Parodontitom [Exchange of cytokines in patients with generalized periodontitis] Sovremennaya stomatologiya – Modern dentistry, 1, 73-75 [in Ukrainian].
Chajkovskaya, I.V. (2008). Vzaiemozviazok lokalnoho syntezu citokiniv
elkozanoidiv, ta metabolitiv NO yak faktoriv patogenezu hronichnoho perebihu heneralizovannoho parodontytu [Interconnection of local synthesis of cytokines eicosanoids, and metabolites NO as factors of the pathogenesis of chronic course of generalized periodontitis]. Aktualni problemy biomineralohii : prohrama ta materialy III Vseukrainskoi nauk.-prakt. konf. – Program and metrics of the 3rd All-Ukrainian Scientific and Practical Conference. Lugansk, 2 [in Ukrainian].
Samojlenko, A.V., Mashenko, I.S. & Makarevich, A.Yu. (2001). Disbalans v sisteme citokinov bolnyh generalizovannym parodontitom i ego korrekciya citokinoterapiei [Imbalance in the system of cytokines in patients with generalized periodontitis and its correction by cytokinotherapy]. Sovremennaya stomatologiya – Modern dentistry, 2, 40-42 [in Ukrainian].
Shmidt, D.V. (2009). Citokiny desnevoi zhidkosti: ih rol v patogeneze i kontrole lecheniya hronicheskogo parodontit [Cytokines of the gingival fluid: their role in pathogenesis and control of chronic periodontitis]. Extended abstract of candidate’s thesis. Perm, 21 [in Russian].
Rogova, M.A. (2002). Citokiny v zubodesnevoi zhidkosti cheloveka [Cytokines in human dentoglossal fluid]. Extended abstract of candidate’s thesis. Moskva, 21 [in Russian].
Kovalchuk, L.V., Rogova, M.M. & Gankovskaya, L.V. (2000). Rol citokinov v mehanizmah razvitiya hronicheskogo vospaleniya vtkani parodonta [The role of cytokines in the mechanisms of the development of chronic inflammation in periodontal tissue] Immunologiya – Immunology, 6, 24-26 [in Russian].
Roberts, F.A., Hockett, R.D., Bucy, R.P. & Michalek, S.M. (1997). Quantitative assessment of inflammatory cytokine gene expression in chronic adult periodontit. Oral Microbiol. Immunology, 12, 6, 336-344.
Dougari-Bagtzoglou, A.I. & Ebersole Dougari-Bagtzoglou, J.L (1998). Increased presence of interleukin-6(IL-6) and IL-8 secreting fibroblast subpopulations in adult periodontitis. J. Periodontol, 69, 8, 899-910.
Delima, A.J., Oates, T. & Assuma, R. (2001). Soluble antogonists’ to interleukin-1 (IL-1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental periodontitis J. Clin. Periodontol, 28, 3, 233-240.
Naruishi, K., Takashiba, S. & Chou, H.H (1999). Role of soluble interleukin-6 receptor in inflamed gingival for binding of interleukin-6 to gingival fibroblasts J. Periodontal. Res., 34, 3, 296-300.
Prabhu, A., Micholowicz, B. & Mathur, A. (1996). Detection of local and systemic cytokines in adult periodontitis. J. Periodontol, 67, 5, 515-522.
Gudaryan, A.A. & Hmara, A.Yu. (2004). Soderzhanie interferona u bolnyh generalizovannym parodontitom i ego korrekciya cikloferonom. [The content of interferon in patients with generalized periodontitis and its correction with cycloferon]. Visnik stomatolohii – Bulletin of dentistry, 1, 20-23 [in Ukrainian].
Takeichi, O., Saito, I., Tsurumachi, T., Moro, I. & Saito, T. (1996). Expression of inflammatory cytokine genes in vivo by human alveral bone-derived polymorphonuclear leucocytes isolated from chronically inflamed sites of bone resorption. Calcif. Tiss. Internat, 58, 4, 244-248.
Melnichuk, G.M. (2006). Patogeneticheskoe znachenie citokinov krovi v razvitii generalizovannogo parodontita [Pathogenetic significance of blood cytokines in development of generalized periodontitis] Sovremennaya stomatologiya. − Modern stomatology, 1, 55-57 [in Ukrainian].
Pinelis, Yu.I., Cybikov, N.N., Malezhik, M.S. & Malezhik, L.P. (2012). Trigernaya rol belkov teplovogo shoka v immunologicheskih reakciyah pri hronicheskom generalizovannom parodontite u lic pozhilogo vozrasta [Trigger role of heat shock proteins in immunological reactions in chronic generalized periodontitis in elderly persons age]. Zabaikalskiy medicinskiy vestnik – Zabaykalsky Medical Bulletin, 1, 33-38 [in Russian].
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