USING QUINAPRIL AND L-ARGININE FOR CORRECTION ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH ANKYLOSING SPONDYLITIS AND ARTERIAL HYPERTENSION
DOI:
https://doi.org/10.11603/2415-8798.2018.2.9012Keywords:
ankylosing spondylitis, quinapril, L-arginine, endothelial dysfunction.Abstract
Mortality rate among patients with AS is 2 times higher the population level. It is caused by cardiovascular disease. Now it is clear that the presence of chronic systemic inflammation is an important predictor of cardiovascular (CV) disease due to the development of endothelial dysfunction (ED).
The aim of the study – to evaluate the efficacy of correction of ED in patients with AS and arterial hypertension with the use of quinapril and L-arginine aspartate.
Materials and Methods. A total of 110 patients with AS were examined with evaluation endothelium-depended vasodilation (EDVD) in response to reactive hyperemia, were chosen patients with EDVD <10 % (n=79), and were divided into 4 groups. Group I included 17 people who received standard therapy. Patients from the group II (n=20) received intravenous infusion of the solution of L-Arginine. Group III included patients with concomitant hypertension and they received quinapril (n=19). Group IV (n=23) consist of patients with hypertension, but their treatment was combination of L-arginine with quinapril.
Results and Discussion. It was found that in the group II there was a significant improvement in the endothelium’s function (EDVD (23.2±2.4) % (p=0.0023), and its normalization were in 7 patients. In patients of the third group, who received only quinapril were not found normalization of EDVD in any of the patients. In last group (IV) 7 patients showed normalization of the endothelium, 10 improvements compared with baseline levels, and 6 no changes were observed.
Conclusions. L-arginine in the complex therapy of patients with AC can significantly reduce the manifestations of ED in patients without concomitant hypertension. Combined use of quinapril in combination with L-arginine demonstrated improvement of endothelial function and control of blood pressure in patients with hypertension.
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