FEATURES OF CHRONIC OBSTRUCTIVE PULMONOLOGY DISEASES WITHOUT COMBINATION AND IN COMBINATION WITH TUBERCULOSIS IN PATIENTS WITH IRON DEFICIENCY STATES
DOI:
https://doi.org/10.11603/2415-8798.2018.1.8645Keywords:
chronic obstructive pulmonary disease, pulmonary tuberculosis, iron deficiency states.Abstract
The combination of chronic obstructive pulmonary disease (COPD) and pulmonary tuberculosis (TB) is an important medical and social problem. At the same time, the presence of iron deficiency states (IDS) in these patients leads to an increase in mortality and disability. Therefore, the study of the prevalence, sexual characteristics and clinical significance of IDS in patients with COPD and / or TB is relevant.
The aim of the study – to learn the features of the course of COPD and in combination of COPD with TB in patients with IDS.
Materials and Methods. 71 patients with COPD from 19 to 73 years of age were examined, 36 of which had COPD in combination with TB. All patients had a general clinical examination, spirometry, were tested for quality of life and a level of anxiety and depression.
Results and Discussion. It was found that the age of patients with COPD was higher than with combined COPD and TB. 55.8 % of patients with COPD and 73.5 % of patients with combined pathology were diagnosed with IDS. It is worth noting that in patients with COPD, chronic anemia (CA) was found to be less likely than latent iron deficiency (LID), and when combined COPD and TB. Patients with acute respiratory viral hypertrophy were higher than the proportion of patients with LID. In TB patients, the mean ESR rates were significantly higher than in patients without IDS. In subgroups with available IDS FEV 1 was lower than in patients without IDS. It is
noteworthy that in patients with combined pathology and IDS a levels of depression and anxiety were significantly lower than in patients without IDS, and the indicator of quality of life (namely, the mental component of health) was significantly higher in patients with combined pathology and IDS.
Conclusions. Patients with COPD have been found to be less likely to have than patients with a combination of COPD and TB. Both patients with COPD and patients with a combination of COPD and TB, the presence of IDS was associated with lower levels of FEV 1, depression and anxiety, as well as higher ESR and quality of life.
References
(2016). World Health Organization. Global tuberculosis Control report. WHO report. WHO report, 214 p.
(2014). Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease, 93.
Miniño, A.M., Xu, J.Q. & Kochanek, K.D. (2010). Deaths : Preliminary data for 2008. National Vital Statistics Reports, 59, 2-8.
Ghimire, H.B. & Li, J.G. (2011). Impact of pulmonary tuberculosis infection on chronic obstructive pulmonary disease. European Respiratory Journal, 38, 4070.
Boiko, M.H., Sukhomlyn, T.A., Boiko, D.M., Tsapenko, Y.P. & Kraievska, O.O. (2011). Dyferentsiina diahnostyka bronkhoobstruktyvnoho syndromu u khvorykh na khronichne obstruktyvne zakhvoriuvannia lehen u poiednanni z tuberkulozom lehen [Differential diagnosis of broncho-obstructive syndrome in patients with chronic obstructive pulmonary disease combined with pulmonary tuberculosis],Tuberkuloz, lehenevi khvoroby, VIL-infektsiia – Tuberculosis, pulmonary diseases, HIV infection, 4 (07), 55-58 [in Ukrainian].
Lee, C.H., Lee, M.C., Shu, C.C., Lim, C.S., Wang, J.Y., Lee, L.N. & Chao, K.M. (2013). Risk factors for pulmonary tuberculosis in patients with chronic obstructive airway disease in Taiwan: a nationwide cohort study. BMC Infect Dis., 13, 194.
Weiss, G. (2002). Pathogenesis and treatment of anaemia of chronic disease. Blood Rev., 16, 87-96.
Cullis, J.O. (2011). Diagnosis and management of anemia of chronic disease : current status. Br. J. Haematol, 153 (3), 289-300.
Oppenheimer, S.J. (2001). Iron and its relation to immunity and infectious disease. J Nutr., 131, 616-633.
Isanaka, S., Mugusi, F., Urassa, W., Willett, W.C., Bosch, R.J., Villamor, E., Spiegelman, D., Duggan, C. & Fawzi, W. (2012). Iron Deficiency and Anemia Predict Mortality in Patients with Tuberculosis. J Nutr., 142 (2), 350-357.
Fidan, A., Tokmak, M. & Kiral, N. (2010). Anemia in COPD and related factors. Chest, 138, 457.
Oliveira, M.G., Delogo, K.N., Oliveira, H.M., Ruffino-Netto, A., Kritski, A.L. & Oliveira, M.M. (2014). Anemia in hospitalized patients with pulmonary tuberculosis. J Bras Pneumol, 40 (4), 403-410.
Kryvenko, V.I., Kachan, I.S., Pakhomova, S.P., Fedorova, O.P., Kolesnyk, M.Iu., Nepriadkina, I.V. & Hrinenko, T.Iu. (2015). Yakist zhyttia ta prykhylnist do likuvannia v klinitsi vnutrishnikh khvorob [Quality of life and adherence to treatment in the Clinic of Internal Diseases], Navchalnyi posibnyk – A Manual, 27-38 [in Ukrainian].
Ahaiev, N.A., Kokun, M.O., Pishko, I.O., Lozinska, N.S. & Ostapchuk, V.V. (2016). Zbirnyk metodyk dlia diahnostyky nehatyvnykh psykhichnykh staniv u viiskosluzhbovtsiv [Collection of methods for diagnosing negative mental states of servicemen], Metodychnyi posibnyk – Methodical manual, K. : NDTs HP ZSU, 97-129 [in Ukrainian].
Byrne, A.L., Marais, B.J., Mitnick, C.D., Lecca, L. & Marks, G.B. (2015). Tuberculosis and chronic respiratory disease: a systematic review International Journal of Infectious Diseases, 32, 138-146.
Obase, Y., Mouri, K., Shimizu, H., Ohue, Y., Kobashi, Y., Kawahara, K. & Oka, M. (2011). Nutritional deficits in elderly smokers with respiratory symptoms that do not fulfill the criteria for COPD. Int J Chron Obstruct Pulmon Dis., 6, 679-683.
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