METABOLISM IN HYPO- AND HYPERTHYROIDISM
DOI:
https://doi.org/10.11603/1681-276Х.2015.3.5170Keywords:
thyroxine, triiodothyronine, hypothyroidism, hyperthyroidism, carbohydrates, lipids, proteins.Abstract
Thyroid hormones are necessary for normal functioning of all organs and systems of the body and affect the cells of all tissues. Thyroid horhmones have anabolic effect on protein metabolism, catabolic effect on lipid metabolism, indirectly regulate the metabolism of carbohydrates, provide energy processes and absorption of oxygen by cells, affect the water-salt balance, myocardium contractility, heart rate, vascular tone. Thyroid dysfunctions (hypo- or hyperfunction) are among the most common endocrine diseases in medical practice.
This review of the literature focuses on the explaining of hypo- and hyperthyroidism development mechanisms and their implications on the metabolism of carbohydrates, lipids and proteins.
References
Воронцов В. Л. Особенности течения 1. атеросклероза у больных, страдающих гипотиреозом / В. Л. Воронцов, О. И. Смирнова // Клин. вестн. – 1997. – № 2. – С. 64–67.
Гайдаев Ю. О. Состояние эндокринологической службы Украины в 2010 г. и подходы к развязке проблемных вопросов / Ю. О. Гайдаев, Р. О. Mоисеенко // Mеждународный эндокринологический журнал. – 2011. – № 2. – С. 13–17.
Петунина Н. А. Синдром гипотиреоза / Н. А. Петунина //РМЖ. – 2005. – Т. 13, № 6 (230). – С. 295–301.
Фадеев В. В. Заболевания щитовидной железы. Проблемы эндокринологии / В. В. Фадеев, Г. А. Mельниченко. – К. : Высшая наука, 2011. – С. 7–14.
Association of polymorphism of CYP2D6 and CYP2C9 genesencoding P-450 proteins of cytochrome with arterial hypertension /V. B. Borodulin, O. V. Shevchenko, E. N. Bychkov [et al.] // Saratov. Journal of Medical Scientific Research. – 2012. – Vol.8, № 4. – P. 933–937.
Association of thyroid functional disease with mortality in a national cohort of incident hemodialysis patients / C. M. Rhee, S. Kim, D. L. Gillen [et al.] // J. Clin. Endocrinol. Metab. – 2015. – Vol.100, № 4. – P. 1386–1395.
Blood lipid, glucose and uric acid in people with subclinical hypothyroidism/ L. B. Liang, M. Zhang, H. J. Huang [et al.] // Sichuan. Da Xue Xue Bao Yi Xue Ban. – 2013. –Vol.44, № 6. – P. 954–956.
Brenta G. Why can insulin resistance be a natural consequence of thyroid dysfunction? / G. Brenta // J. Thyroid Res. – 2011. – P. 152850.
Central hypothyroidism / V. Gupta, M. Lee // Indian. J. Endocrinol. Metab. – 2011. – Vol. 15. – P. 99–106.
Changes in lipoprotein(a) levels in overt and subclinical hypothyroidism before and during treatment / T. Tzotzas, G. E. Krassas, T. Konstantinidis, M. Bougoulia // Thyroid. – 2000. – Vol.10, № 9. – P. 803–808.
Duntas L. H. Thyroid disease and lipids / L. H. Duntas // Thyroid. – 2002. – Vol.12 (4). – P. 287–293.
Ertek S. Hyperthyroidism and cardiovascular complications: a narrative review on the basis of pathophysiology / S. Ertek, A. F. Cicero // Arch. Med Sci. – 2013. – Vol. 9, № 5. – P. 944–952.
Hyperplastic thyroid gland, high serum glycoprotein α-subunit, and variable circulating thyrotropin (TS H) levels as hallmark of central hypothyroidism due to mutations of the TS Hβ gene / M. Bonomi, M. C. Proverbio, G. Weber [et al.] // J. Clin. Endocrinol. Metab. – 2001. – Vol. 86. – P.1600–1604.
Hyperthyroidism and Risk for Bipolar Disorders: A Nationwide Population-Based Study / L. Y. Hu, C. C. Shen, Y. W. Hu [et al.] //PLoS One. – 2013. – Vol. 8, №8. – P. 730–757.
Hyperthyroidism and the Heart / C. Panagoulis, A. Halapas, E. Chariatis [et al.] // Hellenic J. Cardiol. – 2008. – Vol. 49. – Р. 169–170.
Hyperthyroidism with low thyroid hormone / K. Obuobie, M. K. Jones // J. R. Soc. Med. – 2003. – Vol. 96, № 4. – P. 185–186.
IGSF1 deficiency syndrome: A newly uncovered endocrinopathy/ S. D. Joustra, A. S. van Trotsenburg, Y. Sun, M. Losekoot [etal.] // Rare Dis. – 2013. – Vol.1. – P. 24883.
Initial thyroid status and cardiovascular risk factors: the EPIC-Norfolk prospective population study / M. S. Boekholdt, S. M. Titan, W.M. Wersinga [et al.] // Clin. Endocrinol. – 2010. – Vol. 72 (3). – P. 404–410.
Kwaku M. P. Myxedema coma / M. P. Kwaku, K. D. Burman // J. Intensive Care Med. – 2007. – Vol. 22, № 4. – P. 224–231.
Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease / Z. Baloch, P. Carayon, B. Conte‑Devolx [et al.] // Thyroid. – 2003. – Vol.13, № 1. – P. 3–126.
Liles A. M. Common thyroid disorders. A review of therapies. / A. M. Liles, K. Harrell // Adv. Nurse Pract. – 2006. – Vol.14, №1. – P. 29–32.
Melpomeni P. Lipid Abnormalities and Cardiometabolic 22. Risk in Patients with Overt and Subclinical Thyroid Disease / P. Melpomeni, G. Betsi, G. Dimitriadis // J. Lipids. – 2011. – P. 575–840.
Lipid profiles in the untreated patients with Hashimoto Thyroiditis and the effects of thyroxine treatment on subclinical hypothyroidism with Hashimoto thyroiditis / T. Tagami, T. Tamanaha, S. Shimazu [et al.] // Endocrine Journal. – 2010. – Vol. 57, № 3, P. 253–258.
Lipoprotein subfractions in metabolic syndrome and obesity: clinical significance and therapeutic approaches / D. Nikolic, N. Katsiki, G. Montalto [et al.] // Nutrients. –2013. –Vol. 5, № 3. – P. 928–948.
Lymphocitic infundibulo-neurohypophysitis mimicking a pituitary adenoma / L. Giammattei, H. Maslehaty, A. K. Petridis [etal.] // Clin. Pract. – 2011. – Vol. 1, № 3. – P. 48.
Lymphocytic hypophysitis: a rare or underestimated disease? / A. Bellastella, A. Bizzarro, C. Coronella [et al.] // Eur. J. Endocrinol. – 2003. – Vol.149. – P. 363–376.
Management of Subclinical Hyperthyroidism / S. Santos Palacios, E. Pascual-Corrales, J. C. Galofre // Int. J. Endocrinol. Metab. – 2012. – Vol.10, № 2. – P. 490–496.
Modulation of Adipogenic Conditions for Prospective Use of hADSC s in Adipose Tissue Engineering / B. Galateanu, S. Dinescu, A. Cimpean [et al.] // Int. J. Mol. Sci. – 2012. – Vol.13, №12. – P. 15881–15900.
Molecular Functions of Thyroid Hormones and Their Clinical Significance in Liver-Related Diseases / H. C. Chi, C. Y. Chen, M. M. Tsai [et al.] // Biomed Res Int. – 2013. – P. 601361.
New autosomal recessive mutation of the TS Hβ subunit gene causing central isolated hypothyroidism / J. M. Vuissoz, J. Deladoëy, A. Buyukgebiz [et al.] // J. Clin. Endocrinol. Metab. – 2001. – Vol.86. – P. 4468–4471.
Peripheral metabolism of thyroid hormone and glucose homeostasis / A. Chidakel, D. Mentuccia, F. S. Celi // Thyroid. – 2005. – Vol. 15. – P. 899.
Persani L. Clinical review: Central hypothyroidism: pathogenic, diagnostic, and therapeutic challenges / L. Persani // The Journal of Clinical endocrinology and Metabolism. – 2012. – Vol. 97, № 9. – P. 3068–3078.
Ponte E. Overt and subclinical hypothyroidism and atherosclerotic arteriopathy of the lower limbs (clinicaland subclinical) / E. Ponte, H. I. Ursu // Rom. J. Endocrinol. – 1993. – Vol. 31, № 1–2. – P. 71–79.
Proctor G. Type 2 pseudohypoaldosteronism: new insights into renal potassium, sodium, and chloride handling / G. Proctor, S. Linas // Am. J. Kidney Dis. – 2006. –Vol. 48, № 4. – P. 674–693.
Proportion of various types of thyroid disorders among newborns with congenital hypothyroidism and normally located gland: a regional cohort study / R. Gaudino, C. Garel, P. Czernichow [et al.] // ClinEndocrinol. – 2005. – Vol. 62, № 4. – P. 444–448.
Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver / X. Yao, S. Hou, D. Zhang [et al.] // Cell Biosci. – 2014. – Vol. 4. – P. 38–48.
Riis A. L. Elevated regional lipolysis in hyperthyroidism / A. L. Riis, C. H. Gravholt, C. B. Djurhuus [et al.] // Clin Endocrinol. – 2010. – Vol. 74. – P. 769–775.
Serial positron emission tomographic findings in an atypical presentation of fatal familial insomnia / K. J. Bär, F. Häger, I. Nenadic [et al.] // Arch. Neurol. – 2002. –Vol. 59, №11. – P. 1815–1818.
Serum N-terminal-pro-B-type natriuretic peptide (NT -pro-BNP) levels in hyperthyroidism and hypothyroidism / B. Ozmen, D. Ozmen, Z. Parildar [et al.] // Endocr Res. – 2007. – Vol. 32, № 1–2. – P. 1–8.
Serum resistin and insulin-like growth factor-1 levels in patients with hypothyroidism and hyperthyroidism / C. Eke Koyuncu, S. Turkmen Yildirmak, M. Temizel [et al.] // J. Thyroid Res. – 2013. – P. 306–750.
Serum TS H related to measures of body mass: longitudinal data from the HUNT Study, Norwey / S. Anders, N. I. Tern, E. Trine [et al.] // Clin. Endocrinol. – 2011. – Vol. 74. – P. 769–775.
Streetman D. D. Diagnosis and treatment of Graves’ disease / D. D. Streetman, U. Khanderia // Ann Pharmacother. – 2003. – Vol.37. – P. 1100–1109.
Krysiak R. Subclinical thyroid disorders / R. Krysiak, B. Okopień, Z. S. Herman // Pol. Merkur. Lekarski. – 2006. – Vol.126. – P. 573–578.
The Colorado thyroid disease prevalence study / G. J. Canaris, N. R. Manowitz, G. Mayor, E. C. Ridgway // Arch. Intern. Med. – 2000. – Vol. 160, № 4. – P. 526–534.
The Genetic Basis of Graves’ Disease / R. Płoski, K. Szymański, T. Bednarczuk // Curr Genomics. – 2011. – Vol.12, № 8. – P. 542–563.
The IGSF1 deficiency syndrome: characteristics of male and female patients. / S. D. Joustra, N. Schoenmakers, L. Persani [et al.] //J. Clin. Endocrino. Metab. – 2013 Vol. 98, № 12. – P. 4942–4952.
Thermogenic effect of glucose in hypothyroid subjects /A. Kozacz, P. Grunt, M. Steczkowska [et al.] // Int. J. Endocrinol. – 2014. – P. 308017.
Thyroid disorders in elderly patients / S. U. Rehman, D. W. Cope, A. D. Senseney [et al.] // South Med. J. – 2005. – Vol. 98. – P. 543–549.
Thyroid function and age-related macular degeneration: aprospective population-based cohort study – the Rotterdam Study /L. Chaker, G. H. Buitendijk, A. Dehghan [et al.] // BMC Med. – 2015.– Vol.13. – P. 94.
Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism / R. A. Sinha, B. K. Singh, P. M.Yen // Trends Endocrinol Metab. – 2014. – Vol.10. – P. 538–545.
Westerholz S. Thyroid hormone-dependent development of early cortical networks: temporal specificity and the contribution oftrkB and mTO R pathways / S. Westerholz, A. D. de Lima, T. Voigt // Front. Cell Neurosci. – 2013. – Vol. 6, № 7. – P. 121.
Thyrotropin isoforms: implications for thyrotropin analysis and clinical practice / J. M. Estrada, D. Soldin, T. M. Buckey [et al.] // Thyroid. – 2014. – Vol. 24, № 3. – P. 411–423.
Zsuzsa A. Some neurological and psychiatric complications in the disorders of the thyroid gland / A. Zsuzsa // Hung. Med. J. – 2007. Vol.1, № 4. – P. 429–441.
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