RESEARCH OF MACRO- AND MICROELEMENT COMPOSITION OF SALIVA IN DRUG-ADDICT PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS

Abstract

Determination of macro- and microelement composition of saliva in drug-dependent patients is important in the study of pathologies of the oral cavity, especially periodontal tissues.

The aim of the study – to explore the macro- and microelement composition of saliva in drug-addicts patients with chronic generalized periodontitis of initial and first degree.

Materials and Methods. The object of biochemical studies was oral liquid of 24 drug-addicts patients (main group) and 10 non-drug addict patients (comparison group) with chronic generalized periodontitis of initial and first degree. 10 people with intact periodontal (control group). To determine the elements of saliva, such as Fe, Zn, Mn, Cu, Cr, Pl, Sr we used spectral method on the atomicabsorption spectrophotometer S-115 PC. Determination of macroelements was performed on biochemical analyzer.

Results and Discussion. It was found out increase of Ca and reduce in the number of P in patients of the main group compared with those results in the comparison and control groups. Concentration of microelements Fe was higher in drug-addict patients (0.531±0.007 mg/kg) versus indicators of nondrug-addict patients (0.509±0.006mg/kg) and results of healthy people (0.481±0.004 mg/kg). The level of elements Cu, Zn, Mn in oral liquid of drug-abuse patients with HGP was lower compared to the comparison and the control group. There were increasing the concentration of toxic elements Pb, Sr in the oral liquid of drug-addicted patients.

Conclusions. Results demonstrates labile macro- and microelement composition of oral liquid of drug-abuse patients with HGP and possible impact of drugs.