METABOLIC FEAUTURES OF BONE–CARTILAGE TISSUE IN PATIENTS WITH COMORBID PATHOLOGY OF ORGANS OF DIGESTIVE TRACT
DOI:
https://doi.org/10.11603/2415-8798.2017.2.7856Keywords:
comorbid pathology of digestive organ, oxyprolin, rumalon antibodies, alkaline phosphatase, osteoporosis.Abstract
The article describes features of bone metabolism and destruction of connective tissue in patiens with comorbid pathology of digestive organs.
The aim of the study – to explore metabolic features of bone–cartilage tissue in patients with comorbid pathology of digestive organs.
Materials and Methods. There were examined 136 patients with comorbid pathology of gastroduodenal pancreatic area and liver: 30 patients (22 % – 1 group), 44 (32.4 % – 2 group), 62 (45.6 % – 3 group). For verification of diagnosis we used a wide range of clinical and laboratory examinations. Also, we made a densitometric examination of lumbar spine and proximal right femur. Metabolism of bone – cartilage tissue was estimated by concentration of oxyproline, rumalon antibodies and activity of alkaline phosphatase.
Results and Discussion. It was found that all examined patients have hyperproduction of oxyproline and (PmAt)-romalon antibodies, compared to healthy individuals. Rate of bone metabolism – activity of alkaline phosphatase – have tendencies to growth in patients with chronic gastroduodenitis (CGD) and chronic pancreatitis (ChP) on the background of chronic gepatitis (CG). So, patients with combination CGD and ChP subject to availability CG level oxyproline was higher in 25.9 %, romalon antibodies – in 32.6 % than patients with CGD. All patients with liver damage had increase activity of Alcaline phosphotase, but the highest activity of enzyme was in patients with deep changes in bone tissue, which eligible osteoporosis. In all examined patients, not depending on the disease, during osteodefficiency deepening we observed magnification level of oxyproline and romalon antibodies. It was found the reverse link correlation between indices of bone tissue mineral density, oxyproline and romalon antibodies in patients who have comorbid pathology of organs of digestive tract.
Conclusions. Metabolic rate of connective tissue is closely connected with condition of mineral density of bone tissue. In patients with chronic gastroduodenitis on the background of chronic hepatitis the changes of metabolism of bone–cartilage tissue occur than in the other groups (chronic gastroduodenitis, chronic gastroduodenitis in combination with chronic pancreatitis).
References
Povorozniuk, V.V. (2009). Zakhvoriuvannia kistkovo-miazovoi systemy v liudei riznoho viku (Vybrani lektsii, ohliady, statti: u 3-kh tomakh.) [Diseases of the bone and muscular system in people of all ages (Selected lectures, reviews, articles: In 3 volumes.)]. Кyiv, Vol. 3, 664 p. [in Ukrainian].
Povorozniuk, V.V. (2016.) Osteoporozu lehshe zapobihty, nizh likuvaty yoho vazhki uskladnennia [Osteoporosis is easier to prevent than to treat its severe complications]. Uriadovyi kurier - Uryadovy Courier, Sep. 3. Retrieved from (http://ukurier.gov.ua/uk/articles/gerontolog-vladislav-povoroznyuk-osteoporozu-legsh/).
Agrawal, N.K. & Sharma B. (2013). Prevalence of osteoporosis in otherwise Healthy Indian males aged 50 years and above. Arch Osteoporos. Dec. 8, (1−2), 116.
Panʹkiv, I.V. (2016). Stan mineralnoi shchilnosti kistkovoi tkanyny v zhinok postmenopauzalnoho periodu [State of Mineral Density of Bone Tissue in Postmenopausal Women]. Klinichna ta eksperymentalna patolohiia - Clinical and Experimental Pathology, (15), 1 (55), 104-111 [in Ukrainian].
Karimilar, M., Ismaili, F. & Salari, A. (2014). Effects of Levothyroxine and thyroid stimulating hormone on bone loss in patients with primary hypothyroidism. J. Res. Pyarm. Pract, 3, (3), 83−87.
Onigata, K. (2014). Thyroid hormone and skeletal metabolism Clin. Calcium, 24, (6), 821−827.
Tuchendler, D. & Bolanowski, M. (2014). The influense of thyroid dysfunction on bone metabolism Thyroid Res, 7, 13.
Vybyrana, R.Y. & Zhulkevych, I.V. (2012). Faktory formuvannya osteopenichnoho syndromu v cholovikiv khvorykh na khronichnu limfoyidnu leykemiyu [Factors of Osteopenic Syndrome Formation in Men With Chronic Lymphoid Leukemia]. Visnyk naukovykh doslidzhen - Bulletin of scientific research, 3, 60-64 [in Ukrainian].
Guanabens, N. & Pares, A. (2012). Osteoporosis in liver cirrhosis. Gastroenterol. Hepatol, 35, (6), 411−412.
Andreychyn, S.M., Hanʹberher, I.I. & Chernets, T.Yu. (2014). Osoblyvosti kistkovo-khryashchovoho metabolizmu u khvorykh na osteoartroz u poyednanni z virusnym urazhennyam pechinky [Features of bone and cartilage metabolism in patients with osteoarthritis in combination with viral lesion of the liver]. Zbirnyk materialiv pidsumkovoyi naukovo-praktychnoyi konferentsiyi ʺZdobutky klinichnoyi ta eksperymentalnoi medytsynyʺ - Collection of materials of the final scientific and practical conference ʺAchievements of clinical and experimental medicineʺ. Ternopil, May 21, p. 5 [in Ukrainian].
Balatska, N.I. (2013). Defitsyt vitaminu D u naselennia Ukrayiny ta chynnyky ryzyku yoho rozvytku [Vitamin D deficiency in Ukrainian population and risk factors for its development]. Visnyk naukovykh doslidzhen - Bulletin of scientific research, 1, 37-41 [in Ukrainian].
Downloads
Published
How to Cite
Issue
Section
License
Authors who sent their manuscript to "Вісник наукових досліджень. Bulletin of Scientific Research" Surgery agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal. 
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
