IMPACT OF THIOTRIAZOLIN ON THE STATE OF ENDOGENUS INTOXICATION IN THE LATER PERIOD OF DEVOLPMENT OF STOMACH UNDER EXPERIMENTAL PNEUMONIA
DOI:
https://doi.org/10.11603/2415-8798.2017.2.7846Keywords:
pneumonia, peptic ulcer, Thiotriazolin.Abstract
Pneumonia and stomach ulcer are among the most common human diseases that in the XXI century remain important medical and social problems.
The aim of the study – to establish the degree of endogenous intoxication in the later period of gastric ulcer (GU) and experimental pneumonia (EP) and the impact of Thiotriazolin on the affected indicators.
Materials and Methods. The study was conducted on 49 male guinea pigs, weighing 180–210 g. Experimental pneumonia was caused by the method of V. N. Shliapnykov, T. L. Solodov, gastric ulcer was simulated according to the method of V. I. Komarov. Average weight molecules (AWM) content was determined at a wavelength of 254 nm determined by the method of I. A. Volchehorskyi, D. A. Diatlov, E. I. Lvovsk et al.; erythrocytic intoxication index (EII) – according to the method of Tohobaiev A. A., Kurhuzkina A. V., Rikun I. V. and others. Thiotriazolin was injected intramuscularly at a dose of 100 mg per 1 kg daily from the 10th to the 18th day of the experiment and animals were decapitated under ether anesthesia on the 10th and 18th days of the formation of inflammation in the lungs and stomach ulcers.
Results and Discussion. Code red cell toxicity levels in animals with GU and EP on the 10th day significantly increased by 85.2 % (p<0.05) relative to control animals. Results of further research of EII on the 18th day of the diseases model showed its growth compared to intact animals – increased by 96.3 % (p<0.05). Level of AWM on the 10th day per day increased relative to the first group of animals 98.5 % (p<0.05), and later this figure reached its peak – 107.2 % (p<0.05).
Conclusions. The growth of endogenous intoxication in the late period of the EP and GU was found. Use of the drug Thiotriazolin makes a positive impact on its concentration of EII and AWM in the conditions of EP and GU development.
References
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