CLINICAL AND GENETIC PATTERNS OF FORMATION AND COURSE OF BRONCHIAL ASTHMA IN THE CHILDHOOD
DOI:
https://doi.org/10.11603/2415-8798.2016.4.7815Keywords:
bronchial asthma, allergic anamnesis, gene polymorphism, children.Abstract
There were investigated the features of the course of bronchial asthma in
the patients with burdened allergic anamnesis with different Arg16Gly
genotypes of the β2-adrenergic receptors gene. The analysis of the
association of polymorphisms of investigated genes with features of
allergic anamneses was conducted and it was found a correlation
dependence of IgE level from concomitant allergic pathologies.
During the study it was found the prevalence of Arg / Gly (42.57 %)
heterozygous option and Gly / Gly (43.56 %) homozygous option of
ADRβ2 receptor gene, and also it was confirmed the impact of
burdened allergic anamnesis on the realization of asthma in children.
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