ANTIOXIDANT DEFENSE SYSTEM IN EXPERIMENTAL TRAUMA OF THE CHEST AND BOTH HIPS

Authors

  • M. M. Khudobyak I. Horbachevsky Ternopil State Medical University
  • M. I. Marushchak I. Horbachevsky Ternopil State Medical University
  • O. V. Denefil I. Horbachevsky Ternopil State Medical University

DOI:

https://doi.org/10.11603/2415-8798.2016.4.7168

Keywords:

combined trauma, superoxide dismutase, catalase.

Abstract

The aim of our work was to evaluate the parameters of antioxidant defense in tissue of the heart, lungs and liver in dynamics after undergoing combined trauma of the chest and both hips. It was established that the combined trauma of the chest and both hips was accompanied by a statistically significant decrease in the activity of superoxide dismutase after the 1st day of experiment in tissues of the lungs and heart, reaching the lowest values, respectively, in 3–7 and 7–14 days of post-traumatic period, relatively to control. In liver tissue, it was twopeakofSODdecreased activity, in 7th (29.7 %) and 28th days (25.3 %) (p<0.05). The activity of catalase in tissues of the lungs and heart after combined chest trauma and both hips replaced in the same way: in 3 days increases by 30–33 %, while decreases in 28 days, an average of 32 % in relation to control. In liver tissue catalase activity was statistically significantly higher, than the control value, of 34.4 % after 7 days of the experiment, whereas in 28 days, its value was lower than control by 18.9 % (p<0.05).

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Published

2017-02-09

How to Cite

Khudobyak, M. M., Marushchak, M. I., & Denefil, O. V. (2017). ANTIOXIDANT DEFENSE SYSTEM IN EXPERIMENTAL TRAUMA OF THE CHEST AND BOTH HIPS. Bulletin of Scientific Research, (4). https://doi.org/10.11603/2415-8798.2016.4.7168

Issue

No. 4 (2016)

Section

EXPERIMENTAL RESEARCH

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