MORPHOLOGICAL CHANGES IN THE PITUITARY GLAND OF MATURE FEMALE WHITE RATS UNDER THE EXPERIMENTAL CHRONIC TOXIC HEPATITIS AND THEIR IMPACT ON REPRODUCTIVE FUNCTION

Authors

  • L. Ye. Lymar Ternopil State Medical University, Ternopil
  • N. A. Lymar Ternopil State Medical University, Ternopil

DOI:

https://doi.org/10.11603/2415-8798.2016.4.7166

Keywords:

morphological changes, pituitary gland, chronic toxic hepatitis, reproductive function.

Abstract

The demographic situation in Ukraine for many years is unfavorable. Because reproductive health of the nation as an important lever suspension depopulation processes and improve the demographic situation in Ukraineis a priority in the health and development of medical science. A significant reason for the negative demographic indicator is the high level of sterility, which caused 15–25 % in hormonal disorders [1]. Impaired function of the reproductive system continues to be an urgent problem, since it leads to disability and reduced reproduction. A large role in causing this problem belongs not only genetically determined changes in the body, but also the associated pathology. Women have often a combination of reproductive system dysfunction with chronic hepatitis of different genesis. This prompted us to conduct experimental work with the aim of detailed study and analysis of this problem. In the study available to the sources of information we did not find such experimental studies on pathological process modeling and study of structural changes in hormone production organs and chronic hepatitis. We modeled chronic toxic hepatitis in mature female white rats. We studied the results of the clinical, histological studies, indicators of immune and hormonal status, liver function in experimental animals and their reproductive function under the experimental toxic hepatitis. The study involved 40 sexually mature females of white rats that simulated chronic toxic hepatitis (CTH). There were studied the clinical manifestations of the disease, the condition of liver function, hormonal status and morphological changes in the pituitary gland of these animals and their reproductive function.

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Published

2017-02-09

How to Cite

Lymar, L. Y., & Lymar, N. A. (2017). MORPHOLOGICAL CHANGES IN THE PITUITARY GLAND OF MATURE FEMALE WHITE RATS UNDER THE EXPERIMENTAL CHRONIC TOXIC HEPATITIS AND THEIR IMPACT ON REPRODUCTIVE FUNCTION. Bulletin of Scientific Research, (4). https://doi.org/10.11603/2415-8798.2016.4.7166

Issue

No. 4 (2016)

Section

EXPERIMENTAL RESEARCH

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