DECOMPRESSION INFLUENCE OF BILIARY TRACTS ON THE DYNAMICS OF LIPOPEROXIDATION PROCESSES, ANTIOXIDANT PROTECTION AND CYTOLYSIS AFTER THE EXPERIMENTAL THREE DAY CHOLESTASIS
DOI:
https://doi.org/10.11603/2415-8798.2016.4.7165Keywords:
extrahepatic cholestasis, bile duct, liver, cytolysis, ceruloplasmin.Abstract
Extrahepatic cholestasis is one of the urgent problem of modern abdominal surgery. The peculiarities of recovering of morpho-functional liver state after the decompression of bile duct remain less studied. In experiments on non-liner white rats we modeled an obturation cholestasis by the way of bile duct bandaging. In three days the passage of bile recovered and estimated the intensity of lipid peroxidation processes, antioxidant protection and cytolysis in 1, 3, 5 and 7 days. It was established that in one day after the recanalization of common bile duct we noticed the worsening of metabolic processes in liver which due to stimulation of sanogenesis mechanisms in 7 days leads to their recovering in particular normalization of lipid peroxidation processes intensity, the cytolysis decrease. The leading compensatory mechanism is an increase of activity of antioxidant enzymes of superoxide dismutase and catalase and the main blood antioxidant – ceruloplasmin, which continue to be increased in 7 days after the experiment.
References
Antyoksydantno-prooksydantnyy indeks syrovatky krovi shchuriv z eksperymentalʹnym stomatytom i yoho korektsiya zubnymy eliksyramy / A. P. Levytsʹkyy, V. M. Pochtar, O. A. Makarenko, L. I. Hrydina // Odesʹkyy med. zhurn. – 2006. – № 1. – S. 22–25.
Badretdynova A. R. Analyz vozrastno-polovoy struktury bolʹnykh zhelchekamennoy boleznʹyu, ydushchykh na planovuyu kholetsystéktomyyu / A. R. Badretdynova // Praktycheskaya medytsyna. – 2011. – № 50. – S. 60.
Belova S. V. Fermentnyy ymmunomodulyator v terapyy éksperymentalʹnoho autoymmunnoho artryta / S. V. Belova // Tykhookeanskyy med. zhurn. – 2009. – № 3. – S. 70–73.
Borysenko V. B. Dynamyka morfolohycheskykh yzmenenyy kholedokha, pecheny y druhykh vnutrennykh orhanov pry modelyrovanyy mekhanycheskoy zheltukhy v éksperymente / V. B. Borysenko, S. H. Belov, N. Y. Horholʹ // Kharkivsʹka khirurhichna shkola. – 2012. – № 1. – S. 46–52.
Vlyyanye ynfuzyonnoho hepatoprotektora remansol na funktsiyu pecheny krys na modely obturatsyonnoy zheltukhy / N. H. Smyrnova, S. H. Chefu, A. L. Kovalenko, T. D. Vlasov // Éksperymetalʹnaya y klynycheskaya farmakolohyya. – 2010. – T. 73, № 9. – S. 24–27.
Hnatyuk M. S. Morfolohichni zminy pechinky ta yikh korektsiya pryzmodelʹovaniy obturatsiyniy zhovtyanytsi / M. S. Hnatyuk, I. M. Klishch, M. M. Haley // Shpytalʹna khirurhiya. – 2008. – № 4. – S. 78–82.
Doklinichni doslidzhennya likarsʹkykh zasobiv : metodychni rekomendatsiyi ; za red. chl.-kor. AMN Ukrayiny O. V. Stefanova. – K. : Avitsenna, 2001. – 528 s.
Kolb V. H. Spravochnyk po klynycheskoy khymyy / V. H. Kolb, V. S. Kamyshnykov. – Mynsk : Belarusʹ, 1982. – 311 s.
Korolyuk M. A. Metod opredelenyya aktyvnosty katalazy / M. A. Korolyuk, L. Y. Yvanova, Y. H. Mayorova, V. E. Tokarev // Laboratornoe delo. – 1988. – № 1. – S. 16–19.
Nahornaya N. V. Oksydatyvnyy stress: vlyyanye na orhanyzm cheloveka, metody otsenky / N. V. Nahornaya, N. A. Chetveryk // Zdorovʺya dytyny. – 2010. № 2. –– [rezhym dostupu]. – http://www.mif-ua.com/archive/article/12762
Orel YU. M. Strukturni zminy pechinkovoyi tkanyny v umovakh zmodelʹovanoho kholestazu i pislya yoho likvidatsiyi / YU. M. Orel, O. I. Dzyubanovsʹkyy, L. V. Shkrobot // Shpytalʹna khirurhiya. Zhurnal imeni L. YA. Kovalʹchuka. – 2016. – № 2. – S. 45–49.
Ratchyk V. M. Kliniko-laboratorni osoblyvosti eksperymentalʹnoho kholestazu / V. M. Ratchyk, A. V. Kosynsʹkyy, N. V. Prolom // Klinichna khirurhiya. – 2007. – № 2. – S. 81.
Tkachuk O. L. Pechinkovi dysfunktsiyi pislya khirurhichnoyi dekompresiyi u khvorykh na obturatsiyni zhovtyanytsi / O. L. Tkachuk, I. M. Shevchuk, V. A. Myesoyedova // Kharkivsʹka khirurhichna shkola. – 2005. – № 2.1 (17). – S. 107–109.
Chevary S. Rolʹ superoksyddysmutazy v okyslytelʹnykh protsessakh kletky y metod opredelenyya ee v byolohycheskykh materyalakh / S. Chevary, Y. Chaba, Y. Sokey // Lab. delo. – 1985. – № 11. – S. 678–681.
Shevchuk M. H. Postdekompresiyni dysfunktsiyi pechinky u khvorykh na obturatsiyni zhovtyanytsi / M. H. Shevchuk, O. L. Tkachuk, I. M. Shevchuk. – Ivano-Frankivsʹk : Vyd-vo Ivano-Frankivsʹkoho derzhavnoho medychnoho universytetu, 2006. – 212 s.
Comparative study of macro- and microsurgical extrahepatic cholestasis in the rat // M. A. Aller, M. Duran, L. Ortega, J. L Arias // Microsurgery. – 2004. – Vol. 24, N 6. – P. 442–447.
Leukocytes and the inflammatory response in ischemiareperfusion injury / I. Francischett, J. B. Moreno, M. Scholz, W. B. Yoshida // Rev. Bras. Cir. Cardiovasc. – 2010.– Vol. 25 (4). – P. 575–584.
Downloads
Published
How to Cite
Issue
Section
License
Authors who sent their manuscript to "Вісник наукових досліджень. Bulletin of Scientific Research" Surgery agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal. 
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
