THE RESULTS OF APPLICATION OF NEOADJUVANT CHEMORADIOTHERAPY WITH INTRA-ARTERIAL INJECTION OF CYTOSTATICS FOR PATIENTS WITH ESOPHAGEAL CANCER
DOI:
https://doi.org/10.11603/2415-8798.2016.4.7142Keywords:
esophageal cancer, intra-arterial chemotherapy, neoadjuvant chemoradiation therapy, surgical treatment.Abstract
Despite advances in modern cancer treatment outcomes of esophageal cancer remains unsatisfactory. Most scientists recognize integrated approach as the most effective – it includes preoperative chemoradiotherapy followed by surgery. In order to improve the results of treatment we developed the new method of intra-arterial chemotherapy, which is combined with radiotherapy for preoperative stage. To determine the efficacy of neoadjuvant chemoradiotherapy there was conducted a randomized study which included 69 patients with esophageal cancer. 34 patients received preoperative chemoradiotherapy with intra-arterial injection of cytostatics, 35 patients received standard chemoradiation therapy. Short-term results did not differ in frequency of toxic and postoperative complications. Annual survival rate in the main group was 81.0 ± 6.7 %, in the control group – 55.8±9,0 %. Two-year survival rate in the intra-arterial chemotherapy group was 58.3±11,8 %, in a standard chemoradiotherapy group – 33.1±12,1 %. The median of survival rate in the control group was 15 months, and in the main group hasn’t been reached yet. Application of intra-arterial injection of cytostatics in treatment of cancer patients with intrathoracic esophageal cancer significantly increased one-year survival rate from 55.8 to 81.0 % (p<0,05) compared with standard chemoradiation therapy.
References
Enzinger P. C. Esophageal Cancer / P. C. Enzinger, R. J. Mayer // N. Engl. J. Med. – 2003. – Vol. 349. – P. 2241–2252.
Urschel J. D. A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer / J. D. Urschel, H. Vasan // Am. J. Surg. – 2003. – Vol. 185. – P. 538–543.
Preoperative chemoradiotherapy for oesophageal cancer: a systematic review and meta-analysis / F. Fiorica, D. DiBona, F. Schepis [еt al.] // Gut.– 2004. – Vol. 53. – P. 925–930.
Downloads
Published
How to Cite
Issue
Section
License
Authors who sent their manuscript to "Вісник наукових досліджень. Bulletin of Scientific Research" Surgery agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal. 
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
