THE ROLE OF THE NURSE AT THE STAGE OF CONTROLLED OVARY STIMULATION DURING IN VITRO FERTILIZATION CYCLES
DOI:
https://doi.org/10.11603/2411-1597.2026.1.15941Keywords:
controlled stimulation, in vitro fertilization, nurse, embryological stageAbstract
Introduction. Infertility is becoming a global problem that reflects medical, social, and economic issues. A significant part of the population suffers from infertility. One of the main methods of treating infertility is in vitro fertilization (IVF). To obtain a larger number of oocytes, hormonal stimulation of the ovaries is performed. The number of eggs obtained affects the rate of pregnancy and live birth.
The aim of the study – to determine the role of the nurse at the stage of controlled ovarian stimulation in order to increase the effectiveness of IVF.
The main part. This work conducted a study of the embryological stage of IVF in women who were administered drugs for stimulation by a nurse in the IVF clinic in comparison with patients who administered all drugs independently at home. Patients were divided into 2 groups, 50 females in each. Group 1 patients – all drugs for stimulation, including the ovulation trigger, were administered by a clinic nurse, while in Group 2 patients – all drugs, including the ovulation trigger, were administered by the patient independently at home. The anti-Müllerian hormone level and the dose of follicle-stimulating hormone were the same in both groups. However, the number of oocytes obtained was significantly higher in the first group, where patients received injections of drugs by a nurse under the conditions of a manipulation room in a reproductive medicine clinic. In the second group, the total number of oocytes was less than in the first group and the number of blastocysts and euploid embryos was significantly lower than in the first group.
Conclusions. In the second group of patients who performed the doctor’s appointment at home, there is a decrease in the level of the sex hormone estradiol on the day of the puncture appointment, and as a result, a significant (p<0.05) decrease in the number of oocytes, zygotes, blastocysts, and euploid embryos. The results obtained in the study confirmed the crucial role of the nurse in the treatment of infertility by the IVF method. Correctly performed by the nurse the doctor’s prescriptions at the stage of stimulation of superovulation will allow to increase the number of euploid embryos, which will significantly increase the effectiveness of infertility treatment by the method of in vitro fertilization.
References
World Health Organization. 1 in 6 people globally affected by infertility. WHO: [cited 2024 Sep 6]. Available from: https://www.who.int/news/item/04-04-2023-1-in-6-people-globally-affected-by-infertility.
Duffy, J.M.N., Bhattacharya, S., Bhattacharya, S. et al. (2021). Core Outcome Measure for Infertility Trials (COMMIT) initiative. Standardizing definitions and reporting guidelines for the infertility core outcome set: an international consensus development study. Fertil Steril, 115, 201-212. DOI 10.1016/j.fertnstert.2020.11.013.
Sansone, A., Di Dato, de Angelis, Menafra, D., Pozza, C., Pivonello, R. et al. (2018). Smoke, alcohol and drug addiction and male fertility. Reprod Biol Endocrinol., 1 (16), 3. DOI 10.1186/s12958-018-0320-7.
Dakhno, F.V., Kaminskyі, V.V., & O.M.Yuzʹko, О.М. (2011). Dopomizhni reproduktyvni tekhnolohiyi likuvannya bezpliddya [Assisted reproductive technologies for the treatment of infertility]. Kyiv [in Ukrainian].
Chua, S.J., Danhof, N.A., Mochtar, M.H., Van, Wely, McLernon, D.J., Custers, I. et al. (2020). Age-related natural fertility outcomes in women over 35 years: a systematic review and individual participant data meta-analysis. Human Reproduction, 35 (8), 1808-1820. DOI 10.1093/humrep/deaa129.
Vander, Borght, & Wyns, C. (2018) Fertility and infertility: Definition and epidemiology. Clinical Biochemistry, 62, 2-10. DOI 10.1016/j.clinbiochem.2018.03.012.
Practice Committee of the American Society for Reproductive Medicine and the Practice Committee for the Society for Assisted Reproductive Technologies (2021). Electronic address: ASRM@asrm.org. Guidance on the limits to the number of embryos to transfer: a committee opinion. Fertil Steril, 116, 651-654. DOI 10.1016/j. fertnstert.2021.06.050.
Gonen, L.D. (2016). Satisfaction with In Vitro Fertilization Treatment: Patients’ Experiences and Professionals’ Perceptions. Fertil Research and Practice, 2 (6). DOI 10.1186/s40738-016-0019-4.
Haas, J.R., Wiltsey Stirman, S., & Ruzek, J. (2020). The role of nurses in promoting mental health and resilience among patients with infertility. J. Clinical Nursing, 29 (1-2), 167-174.
Gaskins A., & Chavarro J.E. (2018). Role of Nurses in Reproductive Health: Strategies and Outcomes. Fertil Steril, 4 (110), 772-779. DOI 10.1016/j.fertnstert.2018.05.026.
Mahesan, A.M., Chang, P.T., Ronn, R., Paul, A.B.M., Meriano, J., & Casper, R.F. (2022). Preimplantation genetic testing for aneuploidy in patients with low embryo numbers: benefit or harm? J Assist Reprod Genet, 39, 2027-2033. DOI 10.1007/s10815-022-02588-9.
de Loos, A.D., Hund, M., Buck, K., Meun, C., Sillman, J., & Laven, J.S. (2023). Antimüllerian hormone to determine polycystic ovarian morphology. Fertil Steril, 116, 1149-1157.
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Copyright (c) 2026 А. С. Луцький

This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2026-04-28
Published 2026-05-04