Роль дисфункції щитоподібної залози у патогенезі генералізованого пародонтиту (огляд літератури)
DOI:
https://doi.org/10.11603/2311-9624.2018.1.8611Ключові слова:
дисфункція щитоподібної залози, пародонтит.Анотація
Резюме. Ендокринні захворювання є актуальною медико-соціальною проблемою сучасного суспільства. Зміни діяльності щитоподібної залози неминуче позначаються на різних системах організму, у тому числі і на функції і морфології органів і тканин порожнини рота.
Мета дослідження – на основі аналізу літературних даних визначити вплив дисфункції щитоподібної залози на перебіг хронічних запальних захворювань пародонту.
Матеріали і методи. У дослідженні використано бібліосемантичний та аналітичний методи.
Результати досліджень та їх обговорення.У статті викладено сучасні дані щодо перебігу хронічного генералізованого пародонтиту в умовах гіпер- та гіпотиреозу На даний момент не існує остаточної думки щодо впливу тиреоїдних гормонів на кістковий метаболізм, оскільки доведений дуалізм їх ефектів. Різні дослідження показують неоднозначні дані щодо метаболічних змін у тканинах пародонту на тлі дисфункції щитоподібної залози.
Висновок. Аналіз результатів досліджень науковців свідчить про те, що дисфункція щитоподібної залози негативно впливає на перебіг хронічних запальних захворювань пародонту. Незважаючи на велику кількість досліджень, молекулярні механізми впливу тиреоїдних гормонів на кістковий метаболізм загалом та стан тканин пародонту, зокрема, вивчені не повністю.
Посилання
Kravchenko, V.I. & Postol, S.V. (2011). Dynamika zakhvoriuvanosti na patolohiiu shchytopodibnoi zalozy v Ukraini [The dynamics of morbidity in pathology of thyroid gland in Ukraine]. Mezhdunarodnyi Endokrinologicheskii zhurnal – International Endocrinology Journal, 3 (35), 56-59 [in Ukrainian].
Tymkiv, V.V. (2014). Statystychnyi analiz nepukhlynnykh zakhvoriuvan shchytopodibnoi zalozy v Ivano-Frankivskii oblasti protiahom 2007-2011 rr. [Statistical analysis of non-tumor diseases of the thyroid gland in Ivano-Frankivsk region during 2007-2011]. Halytskyi likarskyi visnyk – Galician Medicinal Herald, 21, 1, 96-100 [in Ukrainian].
Tronko, N.D., Mabuchi, K. & Kravchenko V.I. (2013). Iodnyi status i dozy oblucheniia shchitovidnoi zhelezy u postradavshikh vsledstvie Chornobylskoi katastrofy, prozhivaiushchikh v Severnykh regionakh Ukrainy (ukrainsko-amerikanskoe kogortnoe issledovanie) [Iodine status and doses of thyroid irradiation in victims of the Chornobyl disaster living in the Northern regions of Ukraine (Ukrainian-American cohort study)]. Zhurnal NAMN Ukrainy – Journal of the National Academy of Medical Sciences of Ukraine, 19, 3, 355-364 [in Russian].
Bebezov, B.Kh., Nuraliev, M.A. & Kakchekaeeva, T.T. (2013). Taktika lecheniia diffuznogo toksicheskogo zoba [The tactics of treating diffuse toxic goiter]. Klinicheskaia meditcina – Clinical Medicine, 9, 61-67 [in Russian].
Rugge, J.B., Bougatsos, C. & Chou, R. (2015). Screening and Treatment of Thyroid Dysfunction: An Evidence Review for the U.S. Preventive Services Task Force. Annals of Internal Medicine, 162, 1, 35-46.
Vladymyrova, I.M. & Heorhiiants, V.A. (2015). Farmakoterapevtychni napriamky zastosuvannia yodovmisnykh likarskykh roslyn pry riznykh hrupakh zakhvoriuvan shchytopodibnoi zalozy [Pharmacotherapeutic directions of application of iodine-containing medicinal plants in different groups of diseases of the thyroid gland]. Scientific Journal «ScienceRise», 11, 4 (16), 46-54 [in Ukrainian].
Wiersinga, W.M., Duntas, L., Fadeyev, V., Nygaard, B. & Vanderpump, M.P. (2012). 2012 ETA Guidelines: The Use of L-T 4 + L-T 3 in the Treatment of Hypothyroidism. European Thyroid Journal, 1, 55-71.
Garber, J.R., Cobin, R.H. & Gharib, H. (2012). Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocrine Practice journal,18, 988-1028.
Madariaga, A.G., Palacios, S.S., Guillén-Grima, F. & Galofré, J.C. (2014). The Incidence and Prevalence of Thyroid Dysfunction in Europe: A Meta-Analysis. The Journal of Clinical Endocrinology and Metabolism, 99, 923-931.
Vernyhorodskyi, V.S., Fetisova, N.M., Vernyhorodska, M.V., Valentieva, R.V. & Malchenko, O.V. (2017). Dynamika invalidnosti khvorykh na hipotyreoz u ternopilskii oblasti za period 2013-2015 rr. [Dynamics of disability of patients with hypothyroidism in the Ternopil region for the period of 2013-2015.]. Visnyk sotsialnoi hihiieny ta orhanizatsii okhorony zdorov’ia Ukrainy – Bulletin of Social Hygiene and Health Care Organizations of Ukraine, 3 (73), 12-15 [in Ukrainian].
Kadzharian, V.G., Melnik, A.I., Bidzilia, P.P. &. Soloviuk, A.O. (2014). Otcenka sostoianiia lipidnogo obmena pri disfunktcii shchitovidnoi zhelezy [Assessment of the state of lipid metabolism in thyroid dysfunction]. Zaporozhskii meditcinskii zhurnal – Zaporozhye Medical Journal, 1(82), 20-22 [in Russian].
Fadeev, V.V. & Melnichenko, G.A. (2011). Zabolevaniia shchitovidnoi zhelezy. Problemy endokrinologii [Diseases of the thyroid gland. Problems of endocrinology]. Vysshaia nauka – Higher Science, 7-14 [in Russian].
Gaidaev, Iu.O. & Moiseenko, R.O. (2011). Sostoianie endokrinologicheskoi sluzhby Ukrainy v 2010 g. i podkhody k razviazke problemnykh voprosov [The state of endocrinology service of Ukraine in 2010 and approaches to the solution of problematic issues]. Mezhdunarodnyi endokrinologicheskii zhurnal – International Endocrinology Journal, 2 (8), 13-17 [in Russian].
Zelinska, N.B. & Larin, O.S. (2016). Patolohiia shchytopodibnoi zalozy u dytiachoho naselennia Ukrainy [Pathology of thyroid gland in the children's population of Ukraine]. Klinichna endokrynolohiia ta endokrynna khirurhiia – Clinical endocrinology and endocrine surgery, 3 (55), 76-81 [in Ukrainian].
Sutaeva, T.R., Minkailova, S.R., Shamov, I.M. & Omarov, O.G. (2012). Khronicheskii generalizovannyi parodontit u bolnykh endemicheskim zobom [Chronic generalized periodontitis in patients with endemic goiter]. Vestnik novykh meditcinskikh tekhnologii – Bulletin of new medical technologies, 19, 3, 46-47 [in Russian].
Zahid, T.M., Wang, B.Y. & Cohen, R.E. (2011). The effects of thyroid hormone abnormalities on periodontal disease status. Journal of the International Academy of Periodontology, 13 (3), 80-85.
Fabue, L.C., Soriano, Y.J. & Pérez, M.G.S. (2010). Dental management of patients with endocrine disorders. Journal of Clinical and Experimental Dentistry, 2 (4), 196-203.
Pavlova, T.V., Peshkova, E.K. & Kolesnikov, D.A. (2012). Klinicheskie nabliudeniia i analiz stomatologicheskogo statusa patcientov s zabolevaniiami shchitovidnoi zhelezy [Clinical observations and analysis of the dental status of patients with thyroid disease]. Fundamentalnye issledovaniia – Basic research, 4, 97-100 [in Russian].
Denga, O.V., & Kolesnik, K.A. (2012). Rol tireoidnykh gormonov v integralnoy regulyatsii kostnogo metaboliz¬ma v norme i pri gipotireoze [The role of thyroid hormones in the integrated regulation of bone metabolism in normal and hypothyroidism]. Tavricheskiy mediko-biologicheskiy vestnik – Tavrichesky Medico-biological Journal, 15, 1 (57), 332-337 [in Russian].
Melnyk, N.S., Mazur, I.P. & Ryzhyk, V.M. (2008). Strukturno-funktsionalnyi stan kistkovoi tkanyny u khvorykh na heneralizovanyi parodontyt z suputnim zakhvoriuvanniam shchytovydnoi zalozy [Structural-functional state of bone tissue in patients with generalized periodontitis with concomitant thyroid disease]. Arkhiv klinichnoi medytsyny – Archive of clinical medicine, 2, 31-34 [in Ukrainian].
Kozlova, M.V. (2009). Atrofiia alveoliarnoi chasti i otrostka cheliustei pri ostepenicheskom sindrome u bolnykh s patologiei shchitovidnoi zhelezy i gipogonadizmom (sovremennye metody diagnostiki i lecheniia) [Atrophy of the alveolar part and process of the jaws in the osteopenic syndrome in patients with thyroid pathology and hypogonadism (modern methods of diagnosis and treatment)]. Extended abstract of PhD dissertation (Stomatology, Endocrinology), 32, Moscow [in Russian].
Oganian, A.V. (2010). Kliniko-morfologicheskie izmeneniia zubo-cheliustnoi sistemy pri gipotireoze [Clinical and morphological changes in the dento-jaw system with hypothyroidism]. Extended abstract of PhD dissertation (Stomatology, Pathological anatomy), 22, Stavropol [in Russian].
Korenevskaia, N.A. & Gorodetckaia, I.V. (2010). Sostoianie tkanei marginalnogo periodonta pri khronicheskom stresse zavisit ot tireoidnogo statusa organizma [The condition of the marginal periodontal tissues under chronic stress depends on the thyroid status of the organism]. Vestnik Vitebskogo gosudarstvennogo meditcinskogo universiteta – Bulletin of Vitebsk State Medical University, 9, 1, 1-11 [in Russian].
Shneider, O.L. (2008). Tcitomorfometricheskie pokazateli pri khronicheskom generalizovannom parodontite u patcientov s pervichnym gipotireozom [Cytomorphometric indices in chronic generalized periodontitis in patients with primary hypothyroidism]. Institut stomatologii – Institute of Stomatology, 3, 78-79 [in Russian].
Nicholls, J., Brassil, М., Williams, G. & Bassett, J. (2012). The skeletal consequences ofthyrotoxicosis. Journal of Endocrinology, 213, 209-211.
Gorka, J., Taylor-Gjevre, R. & Arnason, Т. (2013). Metabolic and clinical consequences of hyperthyroidism on bone density. International Journal of Endocrinology, 638-727.
Basset, J., & Williams, G. (2009). The skeletal phe¬notypes of TRα and TRβ mutant mice. J. Mol. Endocrinol., 42, 269-282.
Tuchendler, D., & Bolanowski, М. (2014). The influ¬ence of thyroid dysfunction on bone metabolism. Thyroid Research, 7, 12.
Kalajzic, Z., Peluso, E.B., Utreja, A., Dyment, N., Ni¬hara, J., Xu, M. et al. (2014). Effect of cyclical forces on the periodontal ligament and alveolar bone remodeling during orthodontic tooth movement. Angle Orthod., 84, 297-303.
Cardoso, L.F., Maciel, L.M.Z., & de Paula F.J.A. (2014). The multiple effects of thyroid disorders on bone and mineral metabolism. Arquivos Brasileiros de Endocrinologia & Metabologia, 58/5, 452-463.
Piksin, I.N., Davyidkin, V.I. Moskovchenko, A.S., Vilkov, A.V. & Kechaykin, A.N. (2016). Sostoyanie kostnogo metabolizma pri zabolevaniyakh shchitovidnoy zhelezy [The state of bone metabolism in diseases of the thyroid gland]. Meditsinskiy almanakh – Medical Almanac, 4 (44), 154-157 [in Russian].
Dolidze, N.M., Kezeli, D.D., & Kilasoniya, L.O. (2007). Changes in intra- and extracellular Ca2+ concentra¬tion and prostaglandin E2 synthesis in osteoblasts of the femoral bone in experimental hyper- and hypothyroidism. Bulletin of Experimental Biology and Medicine, 144, 17-20.
Tsai, J., Janson, A., Bucht, E., Kindmark, H., Mar¬cus, C., Stark, A. et al. (2004). Weak evidence of thyrotro¬pin receptors in primary cultures of human osteoblast-like cells. Calcified Tissue International, 74, 486-491.
Becerik, S., Afacan, B., & Oztürk, V.Ö. (2011). Gin¬gival crevicular fluid calprotectin, osteocalcin and cross-linked N-terminal telopeptid levels in health and different periodontal diseases. Disease Markers, 31, 343-352.
Drok, V.O. (2015). Vyznachennia pokaznykiv me¬tabolizmu kistkovoi tkanyny u patsiientiv z zuboshche¬lepnymy anomaliiamy ta osteopenichnym syndromom [Determination of bone metabolism in patients with den¬tal anomalies and osteopenic syndrome]. Visnyk problem biolohii i medytsyny – Journal of Biology and Medicine, 2, 2 (119), 79-82 [in Ukrainian].
Galkina, O.P. (2013). Uroven markerov kostnogo metabolizma u podrostkov s generalizovannym parodon¬titom, na fone deformatsiy pozvonochnika [The level of markers of bone metabolism in adolescents with generalized periodontitis, against the backdrop of deformities of the spine]. Visnyk stomatolohii – Journal of Dentistry, 3, 30-33 [in Russian].
Kunimatsu, К., Mataki, S., Tanaka, Н., Mine, N., Ki¬yoki, М., Hosoda, К. et al. (1993). A cross-sectional study on osteocalcin levels in gingival crevicular fluid from periodontal patients. Journal of Periodontology, 64, 865-869.
Lee, A.J., Walsh, T.F., Hodges S.J., Rawlinson, А. (1999). Gingival crevicular fluid osteocalcin in adult periodontitis. Journal of Clinical Periodontology, 26, 252-256.
Wilson, A.N., Schmid, M.J., Marx, D.B., & Rein¬hardt, R.A. (2003). Bone turnover markers in serum and periodontal microenvironments. Journal of Periodontal Research, 38, 355-361.
Nakashima, К., Roehrich, N., & Cimasoni, G. (1994). Osteocalcin, prostaglandin E2 and alkaline phosphatase in gingival crevicular fluid: Their relations to periodontal sta¬tus. Journal of Clinical Periodontology, 21, 327-333.
Melnyk, N.S., & Melnyk, A.S. Markery remodeliuvannia kistkovoi tkanyny u khvorykh na heneralizovanyi parodontyt iz suputnim hipo- i hipertyreozom [Markers of bone remodeling in patients with generalized periodon¬titis with concomitant hypo- and hyperthyroidism]. TEM¬PUS. dspace.zsmu.edu.ua. Retrieved from: http: // dspace. zsmu.edu.ua / bitstream /123456789/3842/1/15_lyst_TEMPUS_%D0%97%D0%94%D0%9C%D0%A3_109-110.pdf [in Ukrainian].
Melnyk, N.S. (2013). Otsinka pokaznykiv parodontalnoho statusu u khvorykh na heneralizovanyi parodontyt na tli porushennia funktsii shchytopodibnoi zalozy [Evaluation of indicators of periodontal status in patients with generalized periodontitis in the background of thyroid disturbance]. Halytskyi likarskyi visnyk – Galician Medicinal Herald, 20, 3, 50-52 [in Ukrainian].
Prodanchuk, A.I., Kiiun, I.D., & Kroitor, M.O. (2012). Zakhvoriuvannia parodonta i somatychna patolohiia [Periodontal disease and somatic pathology]. Bukovynskyi medychnyi visnyk – Bukovinsky Medical Bulletin, 16, 2 (62), 164-168 [in Ukrainian].
Shneider, O.L. & Zhuravlev, V.P. (2004). Zabolevaniia parodonta pri gipofunktcii shchitovidnoi zhelezy (Obzor) [Periodontal Diseases in Thyroid Hyperfunction (Overview)]. Ural – Ural, 6, 31-32 [in Russian].
Denisenko, S.N., Shapashnikova, A.A. & Grigorev, S.S. (2005). Kristallograficheskoe issledovanie smeshannoi nestimulirovanoi sliuny u patcientov s diffuznym toksicheskim zobom [Crystallographic study of mixed unstimulated saliva in patients with diffuse toxic goiter]. Problemy stomatologii – Problems of dentistry, 2, 739 [in Russian].
Moskvina, T.S., Ivanova, L.I., Kaplin, V.N., Fefelov, A.I. & Shilova, F.A. (1993). Sostoianie parodonta i nespetcificheskoi rezistentnosti v dinamike eksperimentalnogo gipo- i gipertireoza [Condition of periodontal and nonspecific resistance in the dynamics of experimental hypo- and hyperthyroidism]. Stomatologiia – Stomatology, 3, 4-7 [in Russian].
Kuriakina, N.V. (2007). Zabolevaniia parodonta [Periodontal disease]. Meditcinskaia kniga – Medical book, 292 [in Russian].
Masalova, N.N. & Zakharenko, R.V. (2009). Sostoianie fosforno-kaltcievogo obmena i kostnogo metabolizma v norme i pri narushenii funktcii shchitovidnoi zhelezy [The state of phosphorus-calcium metabolism and bone metabolism in norm and in violation of thyroid function]. Dalnevostochnyi meditcinskii zhurnal – Far Eastern Medical Journal, 2, 122-125 [in Russian].
Grover, H.S., Kapoor, S. & Saksena, N. (2013). Periodontal Proteomics: Wonders Never Cease. International Journal of Proteomics. doi: 10.1155/2013/850235.
Sewón, L. & Mäkelä, M. (1990). A study of the possible correlation of high salivary calcium levels with periodontal and dental conditions in young adults. Archives of Oral Biology, 35, 1, 211-212.
Ziablitckaia, M.S. & Atrushkevich, V.G. (2014). Patogeneticheskie osnovy razvitiia generalizovannogo parodontita na fone narusheniia metabolizma kaltciia i vitamina D [Pathogenetic bases of development of generalized periodontitis against a background of calcium and vitamin D metabolism disorders]. Innovatsii v stomatolohii – Innovations in dentistry, 1, 2-28 [in Russian].
Uspenskaia, O.A. & Kachesova, E.S. (2017). Izmeneniia biokhimicheskikh pokazatelei krovi pri lechenii bystroprogressiruiushchego parodontita [Changes in biochemical parameters of blood in the treatment of fast-progressive periodontitis]. Problemy stomatologii – Problems of dentistry, 13, 2, 33-38 [in Russian].
Konoplia, E.E. (2002). Stomatologicheskii status i kaltcievo-fosfornyi obmen u bolnykh s patologiei shchitovidnoi i parashchitovidnykh zhelez (Meditcinskie posledstviia avarii na ChAES) [Dental status and calcium-phosphorus metabolism in patients with pathology of the thyroid and parathyroid glands (Medical consequences of the Chernobyl accident)]. Extended abstract of PhD dissertation, Moscow, 24 [in Russian].
Verbovaia, M.V. (2002). Mineralnaia plotnost kosti, pokazateli ee metabolizma i kaltcii-fosfornogo obmena u bolnykh tireotoksikozom [Mineral density of bone, its metabolism and calcium-phosphorus metabolism in patients with thyrotoxicosis]. Osteoporoz i osteopatii – Osteoporosis and osteopathy, 1, 16-19 [in Russian].
Pavlenko, O.A., Nochevnaia, L.B., Zavadovskaia, V.D. & Kilina, O.Iu. (2014). Issledovanie osteopenicheskogo sindroma u patcientov s patologiei shchitovidnoi zhelezy metodom ultrazvukovoi osteometrii [Study of osteopenic syndrome in patients with thyroid pathology using ultrasonic osteometry]. Biulleten sibirskoi meditciny – Bulletin of Siberian Medicine, 13, 2, 31-37 [in Russian].
Mendez, D., Kunder, M., Shashidhar K.N., Venkataswamy, L. (2016). A comparative study of the ionic and total calcium levels in women with thyroid dysfunction. International Journal of Medical Science and Public Health, 5 (04), 633-637.
Hassan, E.E., Ashmaik, A.S., Gabra, H.M. & Elzein, A.O.M. (2013). Assessment of serum levels of calcium and phosphorous in Sudanese patients with hypothyroidism. Asian Journal of Biomedical and Pharmaceutical Sciences, 3 (25), 21-26.
Al-Hakeim, H.K. (2009). Serum levels of lipids, calcium and magnesium in women with hypothyroidism and cardiovascular diseases. Journal of Laboratory Physicians, 1(2), 49-52.