Changes of the content of nitrogen metabolites and endothelin-1 in the oral liquid of patients with generalized periodontitis on the background of type 1 diabetes mellitus with cardiomyopathy

Authors

  • R. Yu. Shkrebnyuk Danylo Halytskyi Lviv National Medical University
  • Yu. L. Bandrivskyі I. Horbachevsky Ternopil State Medical University

DOI:

https://doi.org/10.11603/2311-9624.2016.4.7231

Keywords:

generalized parodontitis, diabetes mellitus, endothelin-1.

Abstract

The work adduces the parameters of endothelial dysfunction according to indices (NO2+NO3) and endothelin-1 (ET–1) in оral serum in patients with generalized parodontitis on the backdround of diabetes mellitus type 1 with  cardiomiopathy (main group) and in persons with GP without general somatic diseases (comparative group). When comparative evaluation of frequency of change of ET-1, NO2+NO3 it was established that patients with GP on the background of diabetes mellitus type 1 with cardiomiopathy differs from patients with GP without general somatic diseases more significant changes of metabolites of nitrogen and endothelin-1, where when intensifying of processes in examined patients’ parodontium the meaning of analyzed indices characterized more pronocenced disbalance.

References

Heneralizovanyy parodontyt / T. D. Zabolotnyy, A. V. Borysenko, A. V. Markov, I. V. Shylivsʹkyy. − Lʹviv : HalDent, 2011. − 240 s.

Kamyshnikov V. S. Spravochnik po kliniko-biokhimicheskim issledovaniyam / V. S. Kamyshnikov. − Minsk, 2004. − 672 s.

Klinicheskaya immunologiya : rukovodstvo dlya vrachey / pod red. akad. RAMN Ye. I. Sokolova. − M. : Meditsina, 2008. − 272 s.

Petrishchev N. N. Fiziologiya i patofiziologiya endoteliya / N. N. Petrishchev, T. D. Vlasov. − SPb. GMU, 2003. − 184 s.

Pudyak V. YE. Imunolohichni aspekty khvorob parodonta ta yikh zvʺyazok iz somatychnoyu patolohiyeyu / V. YE. Pudyak, YU. L. Bandrivsʹkyy, N. N. Bandrivsʹka // Visnyk naukovykh doslidzhenʹ. − 2011. − № 2. − S. 41−44.

Lasher T. F. Biology of the endothelium / T. F. Lasher, M. Barton // Clin. Cardiol. − 2007. − Vol. 10. − P. 3−10.

Warner T. D. Relationships between the endothelin and nitric ozide pathways. Clinical and experimental / T. D. Warner // Pharmacology and Physiology. − 2009. − Vol. 26. − P. 247−252.

Published

2017-02-10

How to Cite

Shkrebnyuk, R. Y., & Bandrivskyі Y. L. (2017). Changes of the content of nitrogen metabolites and endothelin-1 in the oral liquid of patients with generalized periodontitis on the background of type 1 diabetes mellitus with cardiomyopathy. CLINICAL DENTISTRY, (4). https://doi.org/10.11603/2311-9624.2016.4.7231

Issue

Section

Terapeutic stomatology