Peroxide hemolysis of erythrocytes as a manifestation of oxidative stress in patients with generalized periodontitis and complications of duodenal peptic ulcer disease
DOI:
https://doi.org/10.11603/2311-9624.2015.1.6173Abstract
The study involved 83 patients with DPUD, which were divided into 3 groups – group I consisted of 40 patients with DPUD complicated by bleeding, group II included 17 patients with DPUD complicated by ulcer perforation, group III was formed by 26 patients with exacerbation of DPUD. Using Schiller-Pisarev probe, gum inflammation was diagnosed in 100 % of groups I and II. In group III, inflammation was stated in 82.6 % of patients, being significantly less frequent in comparison to group I (p<0.05). Papillary-marginal-alveolar index was >51 % (severe gingivitis) in 89.2 % of patients of group I. In groups II and III, it was diagnosed in 77.4 % and 68.3 % of cases, respectively. Moderate gingivitis (25–50 %) was present in all groups, however mild gingivitis (<25 %) was found only in 42 % of patients in group III. The initial degree of periodontitis, according to PI of A.L. Russel, was seen only in groups II and III. Periodontitis of level I was stated significantly more often in group III compared to group I (p<0.05). Periodontitis of level III in group I significantly exceeded its frequency in group III (p<0.05). In group I, patients with increased peroxide hemolysis of erythrocytes had substantially prevailed (p<0.05). In group III, the number of cases with its normal value was significantly higher (p<0.05). The number of patients with increased peroxide hemolysis of erythrocytes in group I significantly exceeded the respective parameter in group III (p<0.05). Thus, patients with DPUD complicated by bleeding, inhere periodontitis of level III and severe gingivitis. Severe periodontal tissue lesions in patients with complications of DPUD is accompanied by a significant enhancement of lipid peroxidation, in particular peroxide hemolysis of erythrocytes.
References
Horbacheva Y. A. Obshchesomatycheskye aspektы patoheneza y lechenyia heneralyzovannoho parodontyta / Y. A. Horbacheva, A. Y. Kyrsanov, L. Yu. Orekhova // Stomatolohyia. – 2001. – № 1. – S. 26–34.
Horiachkovskyi A. M. Klynycheskaia byokhymyia v laboratornoi dyahnostyke / A. M. Horiachkovskyi. – Yzd. 3-e. – Odessa: «Эkolohyia», 2005. – 616 s.
Kazymirko N. K. Osoblyvosti perekysnoho okyslennia lipidiv ta systemy antyoksydantnoho zakhystu pry vyrazkovii khvorobi dvanadtsiatypaloi kyshky / N. K. Kazymirko, A. O. Areshkovych // Ukrainskyi medychnyi almanakh. – 2005. – № 1, T. 8. – S. 79–82.
Matsko N. V. Osoblyvosti porushen pro- ta antyoksydantnoi system orhanizmu v patohenezi rozvytku zakhvoriuvan parodonta pry hastroduodenalnykh vyrazkakh / N. V. Matsko, Yu. I. Bondarenko // Ukrainskyi medychnyi almanakh. – 2014. – T. 17, № 2. – S. 45–47.
Zalezhnist aktyvatsii POL i efektyvnosti yoho korektsii hlutapironom pry emotsiinomu stresi vid typolohichnykh osoblyvostei reahuvannia orhanizmu / [K. S. Neporada, I. M. Skrypnyk, T. O. Petrushanko ta in.] // Medychna khimiia. – 2002. – T. 4, № 2. – S. 23–26.
Novykova M. A. Vzaymosviaz svobodnoradykalnoho okyslenyia y antyoksydantnoi systemы pry zabolevanyiakh parodonta / M. A. Novykova // Visnyk stomatolohii. – 2011. – № 3. – S. 29–32.
Okyslytelnыi stress y kompleksnaia antyoksydantnaia эnerhokorrektsyia v lechenyy parodontyta / [Y. A. Omarov, S. B. Bolevych, T. N. Savateeva-Liubymova y dr.] // Stomatolohyia. – 2011. – № 1. – S. 10–17.
Riabokon E. N. Prooksydantno-antyoksydantnыi status u bolnыkh parodontytom na fone hastroduodenalnoi patolohyy, assotsyyrovannoi s ynfektsyei N.pylori / E. N. Riabokon, V. V. Oleinychuk // Ukrainskyi medychnyi almanakh. – 2011. – T. 14, № 1. – S. 167–170.
Sylenko Yu. I. Rol vilnoradykalnykh, hemokoahuliuiuchykh ta imunnykh mekhanizmiv u patohenezi heneralizovanoho parodontytu / Yu. I. Sylenko, R. M. Stupnytskyi // Ukrainskyi stomatolohichnyi almanakh. – 2011. – № 1. – S. 79–82.
Tarasenko L. M. Faktorы, determynyruiushchye stressornoe povrezhdenye orhanov polosty rta (obzor) / L. M. Tarasenko // Ukrainskyi stomatolohichnyi almanakh. – 2003. – № 4. – S. 27–30.
Iarova S. P. Osobennosty rasprostranenyia y techenyia vospalytelno-dystrofycheskykh protsessov v parodonte na fone zabolevanyi zheludochno-kyshechnoho trakta / S. P. Yarova, V. S. Alekseeva // Ukrainskyi stomatolohichnyi almanakh. – 2014. – № 2. – S. 105–107.
