TREATMENT OF EARLY STAGES OF GENERALIZED PERIODONTITIS IN PATIENTS WITH IMPAIRED BONE MINERAL DENSITY
DOI:
https://doi.org/10.11603/2311-9624.2025.2.15533Keywords:
periodontitis, bone tissue, bone mineral density, sex.Abstract
Objective. To improve the effectiveness of treatment for generalized periodontitis in patients with low bone mineral density. Methods. Treatment was carried out on 51 patients with generalized periodontitis and low bone mineral density. The main subgroups included: 12 men (42.85%), 11 women (39.29%) of reproductive age, and 5 postmenopausal women (17.86%), who were treated according to a developed therapeutic and preventive complex. The control subgroups consisted of 10 men (43.48%), 10 women of reproductive age (43.48%), and 3 postmenopausal women (13.04%). Results. Six months after treatment, male patients with early-stage to stage I generalized periodontitis in the main group, who received care following the developed therapeutic and preventive complex, showed a significant reduction in the studied indicators compared to baseline values: PMA – decreased by 2.0 times, p<0.001, OHI-S – decreased by 1.7 times, p<0.001, PBI – decreased by 1.6 times, p<0.01, CPI – decreased by 1.6 times, p<0.001, BOP – decreased by 1.5 times, p<0.001. At the same time, in men of the control group with early-stage to stage I generalized periodontitis, the values of these index assessments worsened and did not significantly differ from the baseline values. Six months after treatment, stabilization of dystrophic-inflammatory processes in the periodontal tissues of women of reproductive age in the main group was confirmed by a marked positive dynamic in paraclinical indices, which included further reductions compared to baseline: PMA – decreased by 2.5 times, p<0.001, OHI-S – decreased by 1.4 times, p<0.05, PBI – decreased by 1.6 times, CPI – decreased by 1.5 times, BOP – decreased by 1.9 times, p<0.001. Notably, in women of reproductive age in the control group, six months after treatment, the improvement in parameter values under study was not statistically significant (p>0.05), except for the PMA index, which was 1.2 times lower than baseline (p<0.05). Six months after treatment, women in the main group with early- stage to stage I generalized periodontitis treated according to the developed therapeutic regimen had lower values compared to baseline: PMA – decreased by 2.3 times, OHI-S, PBI, CPI – decreased by 1.5 times, BOP – decreased by 1.8 times (p<0.001). In the control group, the values of the analyzed parameters increased during the same period and were comparable to the pre-treatment data. Conclusion. The therapeutic complex developed and proposed for the management of early-stage to stage I generalized periodontitis, which included agents for both local and systemic use, significantly improved periodontal tissue condition in both male and female patients in the main groups. It achieved stabilization of periodontal tissue status in an average of 82.14±7.23% of individuals with impaired bone mineral density. This positive trend was confirmed by a reduction in the mean index values for both sexes compared to baseline.
References
Бaтiг В.М., Глущeнко Т.А. Взаємозв’язок захворювань пародонта із метаболічним синдромом. Український журнал медицини, біології та спорту. 2018. № 4 (2). С. 14–20. DOi: 10.26693/jmbs04.02.014.
Effects of periodontal and bisphosphonate treatment on the gingival crevicular levels of sclerostin and dickkopf-1 in postmenopausal osteoporosis with and without periodontitis / F. O. Ozden, E. Demir, M. Lutfioglu [et al.]. Journal of periodontal research. 2022. No 57 (4). С. 849–858. DOI: 10.1111/jre.13023. Epub 2022 Jun 4.
Борисенко А.В. . Взаємозв’язок захворювань із метаболічним синдромом: у 4 т. Т. 3. Захворювання пародонта. Київ : Медицина, 2018. 624 с.
Годована О.І. Сучасні основи етіології та патогенезу генералізованих дистрофічно-запальних захворювань пародонта з супутньою системною остеопенією. Вісник проблем біології і медицини. 2017. № 1 (3). С. 35–41. URL: https://repository.pdmu.edu.ua/ handle/123456789/11803
Alayash Z. Association between total body bone mineral density and periodontitis: A Mendelian randomization study / Z. Alayash, S. E. Baumeister, S. L. Reckelkamm [et al.]. J Periodontol. 2023. No 94 (6). С. 777–784. DOI: 10.1002/JPER.22-0249. Epub 2022 Dec 27. PMID: 36433673.
Мащенко І.С.. Гудар’ян О.О., Кучеренко Т.О. Клінічні, імунологічні та метаболічні особливості загостреного і швидкопрогресуючого варіантів генералізованого пародонтита. Сучасна стоматологія. 2020. № 4. С. 26–32. URL: 10.33295/1992-576X-2020-4-26
Reckelkamm S.L. Association between bone turnover markers and periodontitis: A population-based crosssectional study / S. L. Reckelkamm, A. Hannemann, T. Kocher [et al.]. Journal of clinical periodontology. 2022. № 49 (7). С. 633–641. URL: 10.1111/jcpe.13649
Особливості порушення мінеральної щільності кісткової тканини у хворих на генералізований пародонтит з остеопенією / М.М. Рожко, А.В. Пантус, І.Р. Ярмошук та ін. Вісник проблем біології і медицини. 2018. Вип. 4 (2). С. 147. DOI 10.29254/2077-4214-2018-4-2- 147-340-343
Стан метаболізму кісткової тканини у хворих із захворюваннями тканин пародонта / В. М. Лучинський, Т. І. Балабан, М. А. Лучинський та ін. Одеський медичний журнал. 2024. № 2. С. 30–34. DOI 10.32782/2226-2008-2024-2-5
Transcriptional activity of vitamin D receptor in human periodontal ligament cells is diminished under inflammatory conditions / A. Blufstein, C. Behm, В. Kubin [et al.]. Journal of periodontology. 2021. № 92 (1). С. 137–148. Doi: 10.1002/JPER.19-0541
Parodontitis – Therapie einer Volkskrankheit [Periodontitis-therapy of a widespread disease] / B. Dannewitz, B. Holtfreter [et al.]. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. 2021. № 64 (8). С. 931–940. DOI: 10.1007/s00103-021-03373-2
Complications and treatment errors in nonsurgical periodontal therapy / F.тGraziani, M. Tinto, С. Orsolini [et al.]. Periodontology 2000. 2023. № 92 (1). С. 21–61. DOI: 10.1111/prd.12478
Tabor E. The Relationship of Knowledge of Osteoporosis and Bone Health in Postmenopausal Women in Silesia Osteo Active Study / E. Tabor, R. Kuźniewicz, P. Zagórski [et al.]. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. 2018. № 21(1). С. 98–104. DOI: 10.1016/j. jocd.2016.08.005
Thanakun S. Increased Plasma Osteocalcin, Oral Disease, and Altered Mandibular Bone Density in Postmenopausal Women / S. Thanakun, S. Pornprasertsuk- Damrongsri, C. P. Mahasarakham [et al.]. International journal of dentistry. 2019. Oct 24;2019. 3715127. URL: 10.1155/2019/3715127
