ENDOGENOUS INTOXICATION IN PERIODONTITIS OF BACTERIAL-IMMUNE GENESIS AND WHEN USING METAL CROWNS

Abstract

The aim of our study was to assess the level of endogenous intoxication in bacterial-immune periodontitis and to analyze the influencing factors on the course of the disease, particularly considering the use of stamped and cast metal crowns. Bacterial-immune periodontitis is accompanied by the development of endogenous toxic syndrome, characterized by the accumulation of toxic metabolites in the systemic bloodstream and periodontal tissues. In experimental animals, the content of middle molecular weight molecules in blood serum was determined at wavelengths of 254 nm and 280 nm. The adsorption capacity of erythrocytes was assessed using the erythrocyte toxicity index. For studying the morphology of periodontal tissues, hematoxylin and eosin staining was used. The results demonstrated that by day 30 of the experiment, the levels of middle molecular weight molecules in the blood serum of animals with periodontitis increased more than 1.5 times compared to intact animals (p < 0.001). The use of stamped crowns led to a slight reduction in intoxication levels, although the values remained significantly elevated compared to normal. The erythrocyte toxicity index also increased substantially in animals with periodontitis, indicating damage to the cell membrane. Thus, the findings confirm the significant role of endogenous intoxication in the pathogenesis of periodontitis and suggest a possible modulatory effect of orthopedic constructions on systemic manifestations of the inflammatory process. Further research in this field is expected to contribute to the development of optimized approaches to the prevention and treatment of inflammatory periodontal diseases.