Modern views for application of platelet rich plasma In the dentistry
DOI:
https://doi.org/10.11603/2311-9624.2019.3.10445Keywords:
plasma-enriched platelets, growth factor, regeneration of bone tissueAbstract
Summary. It is known that the use of own blood for the treatment of various diseases began in ancient times, since the birth of medicine. Currently, plasma-enriched platelets are one of the successful areas of tissue engineering and cell therapy in medicine. In the evolution of terminology, there are many different variants of the names of plasma-enriched platelets as the final product. In clinical practice it is believed that the stimulating effect of plasma-enriched platelets is possible at a concentration of platelets in it not less than 1 000 000/μl. When tissue damage occurs, platelets play a leading role in the healing and regeneration of tissues due to the release of growth factors. Based on the information of the literature, the high potential of platelet-rich plasma therapy for bone tissue regeneration is shown. So far, no proper clinical studies have been performed on the efficacy of plasma-enriched platelet therapy that would meet all current criteria. Plate-enriched platelet therapy is a promising industry in medicine and needs further research as a new effective and safe method in medical practice.
Therefore, the use of growth factors is particularly interesting in cases where the effectiveness of bone materials and osteointegration are quite questionable (for example, with severe osteoporosis or scar tissue changes). Further studies are needed to determine the optimal concentration of various growth factors and to identify the unknown growth factors that may exist in the plasma-enriched platelets. Such studies could reveal additional benefits of using this treatment for wound healing and bone regeneration.
The aim of the study – analysis of scientific literature on the effectiveness of the use of autologous plasma enriched platelets to optimize the treatment of stomatological diseases.
Materials and Methods. The study used bibliosemantic and analytical methods of research.
Results and Discussion. During the study, the review and analysis of the latest data from domestic and foreign scientific and medical literature on modern aspects of the use of autologous, platelet-enriched plasma for the treatment of dental diseases, review of the main methods for its manufacture, advantages and disadvantages of its application were conducted.
Conclusions. Based on the analysis of available literature on the topic of the study, we concluded that the continued relevance of improved approaches to the treatment of major dental diseases enriched with platelets by plasma. Therefore, on the basis of acquaintance with the data of the literature, it can be concluded that the issue of modern use in dentistry autologous platelet-enriched plasma remains relevant and needs further study.
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