AGE-RELATED MORPHOMETRIC CHARACTERISTICS OF REMODELING OF ARTERIAL BED OF HIND LIMBS IN WHITE RATS WITH EXPERIMENTAL HYPERCHOLESTEROLEMIA
DOI:
https://doi.org/10.11603/ijmmr.2413-6077.2017.2.8237Ключові слова:
hypercholesterolemia, arteries, remodelling, morphometria.Анотація
Background. The human organism is constantly affected by metabolic risk factors. All of them for a long time are asymptomatic and often form in early childhood long before clinical manifestations. However, morphogenesis and morphofunctional features of age-related structural changes in blood vessels of different sites are poorly studied.
Objective. To evaluate the morphometric characteristics of arterial bed remodeling of hind limbs in white rats of PRA and RA with experimentally induced hypercholesterolemia.
Methods. The tissues biopsies from femoral, knee and shin areas were studied by means of histological and morphometric methods.
Results. Experimental hypercholesterolemia caused remodeling of vessels with increasing thickness of medial and endothelial layer of vessels in the investigated parts of the rats’ body. In this case, the external diameter of vessels increased only in femoral area in the reproductive group of rats. In the group of pre-productive animals, the external diameter of the vessels studied was more or less unaffected. Thus, increased thickness of intima and media led to a decrease in arteries capacity. The depth of vascular lesions and the decrease in functional capacity of blood vessels were directly proportional to the duration of the experiment. In the group of reproductive rats, the changes in vascular bed were more evident.
Conclusions. Objective study of the processes allows providing a scientific basis for further research and understanding of the pathomorphism of vascular diseases in humans.
Посилання
Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, et al. Executive Summary: heart disease and stroke statistics – 2013 update. A report from the American Heart Association. Circulation. 2013;127:143–52.
Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al. Executive Summary: heart disease and stroke statistics – 2012 update. Circulation. 2012 Jun 5;125(22):188–97.
Tokarchuk NI, Timchuk EV. Overweight in young children is a factor of risk of illness in the future (review of literature). Modern Pediatrics. 2009;6(28): 54–6.
Halpern AL, Mancini MC, Magalhaes ME, Fisberg M, Radominski R, Bertolami MC, et al. Metabolic syndrome, dyslipidemia, hypertension and type 2 diabetes in youth: from diagnosis to treatment. Diabetol. Metab. Syndr. 2010;2:55–75. https://doi.org/10.1186/1758-5996-2-55.
Polyakov LM, Lushnykova EL, Nepomnyashchykh LM, Russkykh HS, Byushkyna NH, Klynnykova MH, et al. Indicators of lipid metabolism and protein composition of blood plasma lipoproteins of hypothyroid rats at experimental hypercholesterolemia. Fundamental research. 2014;(10):342–5.
Mikhail GS, Alshammari SM, Alenezi MY, Mansour M, Khalil NA. Increased atherogenic low-density lipoprotein cholesterol in untreated subclinical hypothyroidism. Endocr. Pract. 2008;14(5):570–5.
Avtandilov HH. Medical morphometry. Moscow: Medicina; 1990.
Klinkova ЕV, Otteva EN, Harbuzova ОH, Isakova VN, Bandurko EV. Assessment of arterial rigidity in patients with gout and arterial hypertension.. Scientific and practical rheumatology. 2010;(6):40–5.
Safar M, Wang M, Lakatta EG. Central arterial aging: humans to molecules. Handbook of hypertension: arterial stiffness in hypertension. Amsterdam: Elsevier. 2006.
Palluy O, Morliere L, Gris JC, Bonne C, Modat G. Hypoxia/reoxygenation stimulates endothelium to promote neutrophil adhesion. Free Radic. Biol. Med. 1992;13(1):21–30. https://DOI: 10.1016/0891-5849(92)90161-9.
Orlandi A, Marcellini M, Spagnoli LG. Aging influences development and progression of early aortic atherosclerotic lesions in cholesterol-fed rabbits. Arterioscler Thromb Vasc Biol. 2000;20(4):1123–36.
Li Z, Froehlich J, Galis ZS, Lakatta EG. Increased Expression of Matrix Metalloproteinase-2 in the Thickened Intima of Aged Rats. Hypertension. 1999; 33(1):116–23.
Risinger GM Jr, Updike DL, Bullen EC, Tomasek JJ, Howard EW. TGF- suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB. Am J Physiol Cell Physiol. 2010;298(1):191–201. https://doi: 10.1152/ajpcell.00417.2008.
Konova E, Baydanoff S, Atanasova M, Velkova A. Age-related changes in the glycation of human aortic elastin. Exp Gerontol. 2004;39(2):249–54. https://DOI: 10.1016/j.exger.2003.10.003.
Zieman SJ. Mechanisms, Pathophysiology and Therapy of Arterial Stiffness. Arterioscler Thromb Vasc Biol. 2005;25(5):932–43. https://DOI: 10.1161/01.ATV.0000160548.78317.29
Strazhesko ID, Akasheva DU, Dudinskaya YeN, Tkacheva ON. Aging of blood vessels: basic signs and mechanisms. Cardiovascular therapy and prevention. 2012;11(4):93–100.
##submission.downloads##
Опубліковано
Як цитувати
Номер
Розділ
Ліцензія
Автори, які надіслали свій рукопис до Міжнародного журналу медицини та медичних досліджень, погоджуються з такими умовами:
1. Автори зберігають авторські права та надають журналу право на першу публікацію з одночасною ліцензією Creative Commons Attribution License CC-BY-NC, яка дозволяє іншим ділитися роботою з визнанням авторства роботи та початкової публікації в цьому журналі.
2. Автори, здатні укладати окремі додаткові договірні угоди щодо неексклюзивного розповсюдження опублікованої журналом версії роботи (наприклад, опублікувати її в інституційному сховищі чи опублікувати в книзі) з підтвердженням її початкової публікації в цьому журналі.
3. Авторам дозволяється та заохочується публікувати свою роботу в Інтернеті (наприклад, в інституційних репозитаріях або на веб-сайті) до та під час процесу подання, оскільки це може призвести до продуктивного обміну, а також до більш раннього та більшого цитування опублікованої роботи ( Див. Вплив відкритого доступу ).
