СИСТЕМНА БІОЛОГІЯ СТАРІННЯ: МОДЕЛЮВАННЯ МОЛЕКУЛЯРНИХ МЕХАНІЗМІВ РОЗВИТКУ ВІКОВИХ ЗАХВОРЮВАНЬ. КОНЦЕПТУАЛЬНИЙ АНАЛІТИЧНИЙ ОГЛЯД

Автор(и)

  • O.P. Mintser Національна медична академія післядипломної освіти імені П. Л. Шупика https://orcid.org/0000-0002-7224-4886
  • V.Z. Zaliskyi Національна медична академія післядипломної освіти імені П. Л. Шупика

DOI:

https://doi.org/10.11603/mie.1996-1960.2019.2.10314

Ключові слова:

системна біологія, старіння, молекулярні механізми, математичне моделювання

Анотація

Феномен старіння включає групу взаємопов'язаних процесів, що відбуваються на організмовому, тканинному, клітинному та молекулярно-генетичному рівнях. Давно висловлювалося припущення, що старіння тісно пов'язано зі складною динамікою фізіологічних систем, які підтримують гомеостаз і, зокрема з дерегуляцією регуляторних молекулярних мереж. У роботі представлено докази важливості динаміки таких складних систем при старінні й того, що фізіологічна дерегуляція (поступове руйнування здатності складних регуляторних мереж підтримувати гомеостаз) є емерджентною властивістю цих мереж, що грає важливу роль у старінні. Завданням цього огляду є узагальнення наявних концепцій про основні детермінанти старіння та довголіття, а також розгляд тенденцій розвитку математичних моделей процесів старіння. Показано, що відсутність інтегрованих трансляційних досліджень на шляху розвитку системної медицини та системної біології є одним із основних факторів, що обмежують надання сучасних засобів у вирішенні проблеми боротьби зі старінням. Серед основних факторів старіння звернуто увагу на те, що вплив на мітохондрії представляється привабливою перспективою для досягнення покращання здоров'я та тривалості життя, оскільки омолодження старих мітохондрій може виявитися важливою терапевтичною стратегією для покращання здоров'я літніх людей. Постулюється також, що швидкість і простота інтеграції сучасних програмних комплексів для моделювання біологічних систем дозволяють дослідникам вивчати великі моделі, включаючи їх взаємодію в багатовимірних форматах із ансамблями невеликих моделей.

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2019-07-29

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Mintser, O., & Zaliskyi, V. (2019). СИСТЕМНА БІОЛОГІЯ СТАРІННЯ: МОДЕЛЮВАННЯ МОЛЕКУЛЯРНИХ МЕХАНІЗМІВ РОЗВИТКУ ВІКОВИХ ЗАХВОРЮВАНЬ. КОНЦЕПТУАЛЬНИЙ АНАЛІТИЧНИЙ ОГЛЯД. Медична інформатика та інженерія, (2), 4–24. https://doi.org/10.11603/mie.1996-1960.2019.2.10314

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