ЕФЕКТИВНІСТЬ ВИКОРИСТАННЯ ВІТАМІНУ D У КОМПЛЕКСНОМУ ЛІКУВАННІ БЕЗПЛІДДЯ У ЖІНОК ІЗ СИНДРОМОМ ПОЛІКІСТОЗНИХ ЯЄЧНИКІВ

Автор(и)

  • M. S. Khmil Тернопільський національний медичний університет імені І. Я. Горбачевського МОЗ України
  • S. V. Khmil Тернопільський національний медичний університет імені І. Я. Горбачевського МОЗ України Медичний центр «Клініка професора Стефана Хміля»
  • N. Ya. Chudiiovych Медичний центр «Клініка професора Стефана Хміля»
  • A. S. Khmil-doswald Медичний центр «Клініка професора Стефана Хміля»
  • L. M. Malanchuk Медичний центр «Клініка професора Стефана Хміля»

DOI:

https://doi.org/10.11603/24116-4944.2019.2.10912

Ключові слова:

вітамін D, синдром полікістозних яєчників, безпліддя, метаболічні порушення, допоміжні репродуктивні технології

Анотація

Проблема безплідного шлюбу залишається актуальною в сучасному акушерстві, гінекології та репродуктології. Синдром полікістозних яєчників є однією з найчастіших причин ановуляторного безпліддя, що являє собою найпоширенішу ендокринну патологію у жінок репродуктивного віку, асоційовану з безпліддям, що характеризується гіперандрогенією, морфологічно кістознозміненими яєчниками та порушенням менструального циклу. У статті коротко представлено сучасні погляди на діагностику та лікування даної ендокринопатії. Висвітлено численні дані сучасної вітчизняної та зарубіжної літератури щодо ефективності використання вітаміну D у комплексному лікуванні та прегравідарній підготовці жінок із синдромом полікістозних яєчників. Доведено його зв’язок із фертильністю, важливу роль у патогенезі синдрому полікістозних яєчників, взаємозв’язок з метаболічними та репродуктивними порушеннями, роль у нормальному перебігу вагітності.

Посилання

Yuzko, O.M., & Yuzko, T.A. (2009). Podolannia bezpliddia za dopomohoiu reproduktyvnykh tekhnolohii [Overcoming infertility through reproductive technologies]. Medychni aspekty zdorovia zhinky – Medical aspects of womans health, 3 (20) [in Ukrainian].

Kapustin, E.V., & Herevych, H.I. (2016). Mistse ta rol dopomizhnykh reproduktyvnykh tekhnolohii (DRT) u likuvanni nepliddia ta zberezhenni fertylnosti [Place and role of assisted reproductive technologies (ART) in the treatment of infertility and fertility preservation]. Akusherstvo. Hinekolohiia. Henetyka – Obstetrics, gynecology, genetics, 2 (2), 30-33 [in Ukrainian].

Zaliska, O.M., & Huz, V.S. (2011). Dopomizhni reproduktyvni tekhnolohii u sviti y Ukraini ta yikhni farmako-ekonomichni aspekty [Assistive reproductive technologies in the world and Ukrai­ne and their pharmacoeconomic aspects]. Ratsionalna farmako­terapiia – Rational pharmacotherapy, 4 (21), 35-37 [in Ukrainian].

Yuzko, T.A., Yuzko, O.M., Zhebchuk, A.B., Zakharenko, L.V., Savchuk, L.T., Chemorkina, I.V., & Vladychenko, K.A. (2014). Istoriia vprovadzhennia dopomizhnykh reproduktyvnykh tekhnolohii pry likuvanni bezliddia na Bukovyni [History of introduction of assisted reproductive technologies in the treatment of infertility in Bukovina]. Bukovynskyi medychnyi visnyk – Bukovyna Medical Bulletin, 1 (69), 229-231 [in Ukrainian].

Tyurina, N.A., & Sayfetdinova, Yu.F. (2014). Prichiny zhenskogo bezplodiya [Causes of female infertility]. Ogarev-online. Klinicheskaya meditsina – Ogarev-online. Clinical medicine, 12 [in Russian].

Manusharova, R.A. (2014). Beslodnyy brak [Infertile marriage]. Effektivnaya farmakoterapiya, Endokrinologiya – Effective pharmacology, endocrinology, 1 (9) [in Russian].

Guriyev, T.D. (2010). Sindrom polikistoznykh yaichnikov [Polycystic ovary syndrome]. Ausherstvo. Ginekologiya I reproduktsiya – Obstetrics, gynecology and reproduction, 4 (2), 10-15 [in Russian].

Nazarenko, T.A. (2008). Sindrom polikistoznykh yaichnikov. Sovremennyye podkhody k diagnostike I lecheniyu besplodiya [Polycystic ovary syndrome. Modern approaches to the diagnosis and treatment of infertility]. Moscow: MEDpress-inform. [in Russian].

Aubuchon, M, & Legro, R.S. (2011). Polycystic ovary syndrome: Current infertility management. Clin Obstet Gynecol, 54 (4), 675-684. DOI: https://doi.org/10.1097/GRF.0b013e3182353c98

Amato, P., & Simpson, J.L. (2005). The genetics of polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol, 18, 707-718. DOI: https://doi.org/10.1016/j.bpobgyn.2004.05.002

Givens, J.R. (1988). Familial polycystic ovarian disease. Endocrinol Metab Clin N Am, 17, 771-783. DOI: https://doi.org/10.1016/S0889-8529(18)30409-2

Diamanti-Kandarakis, E., Kandarakis, H., & Legro, R.S. (2006). The role of genes and environment in the etiology of PCOS. Endocrine, 30, 19-26. DOI: https://doi.org/10.1385/ENDO:30:1:19

Shannon, M., & Wang, Y. (2012). Polycystic ovary syndrome: A common but often unrecognized condition. J Midwifery Womens Health, 57, 221-230. DOI: https://doi.org/10.1111/j.1542-2011.2012.00161.x

McCartney, C.R., & Marshall, J.C. (2016). Polycystic ovary syndrome. N Engl J Med, 375 (1), 54-64. DOI: https://doi.org/10.1056/NEJMcp1514916

Robert, L.R., & David, A.E. (2016). The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited. Endocr rev, 37 (5), 467-520.

Qin, K.N., & Rosenfield, R.L. (1998). Role of cytochrome P450c17 in polycystic ovary syndrome. Mollecular and Cellular Enocr, 145 (1-2), 111-121. DOI: https://doi.org/10.1016/S0303-7207(98)00177-4

Panda, P.K., Rane, R., Ravichandran, R., Singh, S., & Panchal, H. (2016). Genetics of PCOS: A systematic bioinformatics approach to unveil the proteins responsible for PCOS. Genomics Data, 8, 52-60. DOI: https://doi.org/10.1016/j.gdata.2016.03.008

Maggofin, D.A. (2006). Ovarian enzyme activities in women with polycystic ovary syndrome. Fertil and Steril, 86 (1), 9-11. DOI: https://doi.org/10.1016/j.fertnstert.2006.03.015

Deswal, R.., Yadav, A., & Dang, A.S. (2018).. Sex hormone binding globulin - an important biomarker for predicting PCOS risk: A systematic review and meta-analysis. Syst Biol Reprod Med, 64 (1), 12-24. DOI: https://doi.org/10.1080/19396368.2017.1410591

Mehrabian, F., & Afghahi, M. (2013). Can Sex-hormone Binding Globulin Considered as a Predictor of Response to Pharmacological Treatment in Women with Polycystic Ovary Syndrome? Int J PrevMed, 4 (10), 1169-1174.

Chen, C., Smothers, J.C., Lange, A., Nestler, J.E., Strauss, J.F., Wickham, E.P. (2010). Sex Hormone-Binding Globulin Genetic Variation: Associations with Type 2 Diabetes Mellitus and Polycystic Ovary Syndrome. Minerva Endocrinol, 35 (4), 271-280.

Jayagopal, V., Kilpatrick, E.S., Jennings, P.E., Hepburn, D.A., & Atkin, S.L. (2003). The Biological Variation of Testosterone and Sex Hormone-Binding Globulin (SHBG) in Polycystic Ovarian Syndrome: Implications for SHBG as a Surrogate Marker of Insulin Resistance. JCEM, 88 (4), 1528-1533. DOI: https://doi.org/10.1210/jc.2002-020557

Reshetnikov, I.B., Nesterenko, Z.A., Matsneva, I.A., Mosolova, M.Yu., Muravyeva, P.A., & Grabuzdov, A.M. (2016). Sindrom polikistoznykh yaichnikov: osobennosti diagnostiki [Polycystic ovary syndrome: diagnostic features]. Molodoy uchenyy – Young scientist, 26 (2), 38-41 [in Russian].

Jain, P., Jain, M., Haldar, C., Singh, T.B., & Jain, S. (2013). Melatonin and its correlation with testosterone in polycystic ovarian syndrome. J Human Reprod Sci, 6 (4), 253-258. DOI: https://doi.org/10.4103/0974-1208.126295

Arentz, S., Abbott, J.A., Smith, C.A., & Bensoussan, A. (2014). Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings. BMC Complement Altern Med, 14, 511. doi: 10.1186/1472-6882-14-511. DOI: https://doi.org/10.1186/1472-6882-14-511

Rosenfield, R.L. (2015). The polycystic ovary morphology-polycystic ovary syndrome spectrum. J Pediatr Adolesc Gynecol, 28 (6), 412-419. DOI: https://doi.org/10.1016/j.jpag.2014.07.016

Yang, X., Quan, X., Lan, Y., Wei, Q., Ye, J., Yin, X., …, & Yang Y. (2018). Serum chemerin level in women with PCOS and its relation with the risk of spontaneous abortion. Gynecol Endocrinol, 34 (10), 864-867. DOI: https://doi.org/10.1080/09513590.2018.1462316

Yang, H.L., Zhou, W.J., Gu, C.J., Meng, Y.H., Shao, J., Li, D.J., & Li, M.Q. (2018). Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome.Am J Reprod Immunol, 80 (1), e12839. doi: 10.1111/aji.12839. DOI: https://doi.org/10.1111/aji.12839

Grigoryan, O.R., & Andreyeva, E.N. (2015). Sindrom polikistoznykh yaichnikov-oddalennyye riski [Polycystic Ovary Syndrome is a ousted risk]. Effektivnaya farmakoterapiya. Akusherstvo I ginekologyya – Effective pharmacotherapy. Obstetrics and gynecology, 1 (5) [in Russian].

Urbanovych, A.M. (2018). Syndrom polikistoznykh yaiechnykiv u shchodennii praktytsi [Polycystic ovary syndrome in daily practice]. Mezhdunarodnyy zhurnal endokrinologii – International journal of endocrinology, 14 (1), 40-45 [in Ukrainian].

Bagos, P.G. (2009). MTHFR C677T polymorphisms in PCOS: a meta-analysis. Mol. Hum. Reprod, 15 (1), 19-26. DOI: https://doi.org/10.1093/molehr/gan072

Arkhypkina, T.L. (2015). Osoblyvosti homotsysteinemii u molodykh zhinok khvorykh na syndrome polikistoznykh yaiechnykiv [Peculiarities of homocysteine in young women suffer from polycystic ovarian syndrome]. Svit medytsyny ta biolohii –The world of medicine and biology, 1 (48), 9-13 [in Ukrainian].

Kapshuk, I.M. (2015). Osoblyvosti terapii syndromu polikistoznykh yaiechnykiv na foni nadlyshkovoi masy tila [Special treatment of the syndrome of polycystic eggs on the background of the masses.]. Reproduktyvna endokrynolohiia – Reproductive endocrinology, 5 (25), 21-26 [in Ukrainian].

Sidorova, I., Unanyan, A., Vlasov, R., Evtina, I., & Karpov, D. (2011). Giperplasticheskiye protsessy endometriya: osobennosti kliniki I terapii [Endometrial hyperplastic processes: clinical features and therapy]. Vrach – Doctor, 6, 58-60 [in Russian].

Mutter, G., Zaino, R., & Baak, J. (2007). Benign Endometrial Hyperplasia Sequence and Endometrial Intraepithelial Neoplasia. Int. J. Gynecolog. Patholog, 26 (2), 103-114. DOI: https://doi.org/10.1097/PGP.0b013e31802e4696

Strizhakov, A.N., & Davydov, A.I. (2011). Dobrokachestvennyye zabolevaniya matki [Benign deseases of the uterus]. Moscow: GEOTAR-Media.

The Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). (2004). Hum Reprod.,19 (1), 41-47. DOI: https://doi.org/10.1093/humrep/deh098

Voulgaris, N., Papanastasiou, L., Piaditis, G., Angelousi, A., Kaltsas, G., Mastorakos, G., & Kassi E. (2017). Vitamin D and aspects of female fertility. Hormone (Athens), 16 (1), 5-21.

Irani, M., & Merhi, Z. (2014). Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril., 102 (2), 460-468. DOI: https://doi.org/10.1016/j.fertnstert.2014.04.046

Michelle, M.P., Chelsea, N.F., Shvetha, M.Z., Sunni, L.M., James, H., & Segars, J. (2015). Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review. Assist Reprod Genet., 32 (3), 323-335.

Nestler J.E., Reilly, E.R., Cheang, K.I., Bachmann, L.M., Downs, R.W. (2012). A Pilot Study: Effects of Decreasing Serum Insulin with Diazoxide on Vitamin D Levels in Obese Women with Polycystic Ovary Syndrome. Jr Trans Am Clin Climatol Assoc., 123, 209-220.

Hammami, M., & Yusuf, A. (2017). Differential effects of vitamin D2 and D3 supplements on 25-hydroxyvitamin D level are dose, sex, and time dependent: a randomized controlled trial. BMC Endocr Disord, 17. DOI: https://doi.org/10.1186/s12902-017-0163-9

Shieh, A., Chun, F., Ma, C., Witzel, S. Meyer, B., Rafison, B., …, & Adams, J. (2016). Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance. J Clin Endocrinol Metab, 101 (8), 3070-3078. DOI: https://doi.org/10.1210/jc.2016-1871

Garg, D., Grazi, R., Lambert-Messerlian, G., & Merhi, Z. (2017). Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS. J Assist Reprod Genet., 34 (11), 1507-1513. DOI: https://doi.org/10.1007/s10815-017-1011-6

Luk, J., Torrealday, S., Perry, G.N., & Pal L. (2012). Relevance of vitamin D in reproduction. Hum Reprod, 27 (10), 3015-3027. DOI: https://doi.org/10.1093/humrep/des248

Yahya, A.A., Abdulridha, M.K., & Al-Rubuya, B.J. (2018). The Effect of Vitamin D3 and Co-enzyme Q10 Supplementation on Metabolic Biomarkers in Women with Clomiphene Citrate Resistant Polycystic Ovary Syndrome. AJPS, 18 (2), 142-150. DOI: https://doi.org/10.32947/ajps.v18i2.488

Mogili, K.D., Karuppusami, R., Thomas, S., Chandy, A., Kamath, M., & Aleyamma, T.K. (2018). Prevalence of vitamin D deficiency in infertile women with polycystic ovarian syndrome and its association with metabolic syndrome – A prospective observational study. EJOG, 229, 15-19. DOI: https://doi.org/10.1016/j.ejogrb.2018.08.001

Haussler, M.R., Jurutka, P.W., Mizwicki, M., & Norman, A.W. (2011). Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)2vitamin D3: genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab. – 2011. Vol. 25 (4). – P. 543-559. doi: 10.1016/j.beem.2011.05.010. DOI: https://doi.org/10.1016/j.beem.2011.05.010

Rosen, C.J., Adams, J.S., & Bikle, D.D. (2012). The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev, 33, 456-492. DOI: https://doi.org/10.1210/er.2012-1000

Al-Daghri, N.M., Mohammed, A.K., Al-Attas, O.S., Ansari, M.G., Wani, K., Hussain, S.D., …, & Alokail, M.S. (2017). Vitami D receptor gene polymorphism modify cardiometabolic response to vitamin D supplementation in T2DM patients. Scientific Reports, 7 (1), 8280.

Triantos, C., Aggeletopoulou, I., Kalafateli, M., Spantidea, P.I., Vourli, G., Diamantopoulou, G., …, & Thomopoulos, K. (2018). Prognostic significance of vitamin D receptor (VDR) gene polymorphism in liver cirrhosis. Sci Rep. – 2018. – Vol. 8 (1). – P. 14065. doi: 10.1038/s41598-018-32482-3. DOI: https://doi.org/10.1038/s41598-018-32482-3

Bakke, D., Chatterjee, I., Agrwal, A., Dai Ya., & Sun, J. (2018). Regulation of microbiota by vitamin D receptor: a nuclear weapon in metabolic diseases. Nucl Receptor Res. – 2018. – Vol. 5. – P. 101377. DOI: https://doi.org/10.11131/2018/101377

Strange, R.C., Shipman, K.E., & Ramachandran, S. (2015). Metabolic syndrome: a review of the role of vitamin D in mediating susceptibility and outcome. World J Diabetes, 6 (7), 896-911. DOI: https://doi.org/10.4239/wjd.v6.i7.896

Boucher, B.J. (2012). Is vitamin D status relevant to metabolic syndromе? Dermatoendocrinol, 4 (2), 212-224. DOI: https://doi.org/10.4161/derm.20012

Pittas, A.G., Lau, J., Hu, F.B., & Dawson-Hughes, B. (2007). The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab, 92, 2017-2029. DOI: https://doi.org/10.1210/jc.2007-0298

Mangin, M., Sinha, R., & Fincher, K. (2014). Inflammation and vitamin D: the infection connection. Inflamm Res, 63 (10), 803-809. DOI: https://doi.org/10.1007/s00011-014-0755-z

Vanlint, S. (2013). Vitamin D and obesity. Nutrients, 5 (3), 949-956. DOI: https://doi.org/10.3390/nu5030949

Khorsavi, Z.S., Kafeshani, M., Tavasoli, P., Zadeh, A.H., & Entezari, M.H. (2018). Effect of Vitamin D Supplementation on Weight Loss, Glycemic Indices, and Lipid Profile in Obese and Overweight Women: A Clinical Trial Study. Int J Prev Med, 9, 63.

Martins J. S., Palhares M., Teixeira O., Ramos M. (2017). Vitamin D Status and Its Association with Parathyroid Hormone Concentration in Brazilians. J Nutr Metab, 2017, 9056470. DOI: https://doi.org/10.1155/2017/9056470

Mozhinskaya, Yu.V., Belik, S.N., Podgornyy, I.V., & Evdokimova, E.G. (2016). Vozmozhnosti ispolzovaniya vitamina D3 v lechenii besplodiya. Obuslovlennogo sindromom polikistoznykh yaichnikov [The possibility of using vitamin D3 in the treatment of infertility. caused by polycystic ovary syndrome]. Molodoy uchenyy – Young scientist, 18 (1), 58-60 [in Russian].

Gafarovam, E.A. (2016). Kliniko-laboratornyye proyavleniya SPKYa v zavisimosti ot fenotipicheskikh osobennostey i urovnya vitamina D v organizme [Clinical and laboratory manifestations of PCOS, depending on the phenotypic characteristics and the level of vitamin D in the org anisme]. Prakticheskaya meditsina – Practical medicine, 1 (93), 80-84 [in Russian].

Lagowska, K. (2018). The relationship between vitamin D status and the menstrual cycle in young women: a preliminary study. Nutrients, 10 (11), pii: E1729. doi: 10.3390/nu10111729. DOI: https://doi.org/10.3390/nu10111729

Dovnik, A., & Mujezinovic, F. (2018). The association of vitamin D levels with common pregnancy complications. Nutrients. – 2018. Vol. 10 (7). – P. pii: E867. doi: 10.3390/nu10070867. DOI: https://doi.org/10.3390/nu10070867

Ozkan, S., Jindal, S., Greenseid, K., Shu, J., Zeitlian, G., & Hickmon, C. (2010). Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril, 94, 1314-1319. DOI: https://doi.org/10.1016/j.fertnstert.2009.05.019

Lerchbaum, E., & Rabe, T. (2014). Vitamin D and female fertility. Curr Opin Obstet Gynecol., 26 (3), 145-150. DOI: https://doi.org/10.1097/GCO.0000000000000065

Pagliardini, L., Paola, V., Molgora, M., Persico P., Salonia A., Vailati S., …, & Candiani, M. (2015). High prevalence of vitamin D deficiency in infertile women referring for assisted reproduction. Nutrients, 7 (12), 9972-9984. DOI: https://doi.org/10.3390/nu7125516

Zhao, J., Liu, S., Wang, Y., Wang, P., Qu, D., Liu, M., …, & Liu, Y. (2019). Vitamin D improves the outcome of in vitro fertilization (IVF) in infertile women with polycystiv ovary syndrome and insulin resistance. Minerva Med., 110 (3), 199-208. doi: 10.23736/S0026-4806.18.05946-3. DOI: https://doi.org/10.23736/S0026-4806.18.05946-3

Alzaidi, M.M., Almir, H., Khormi, A., Alltaleb, Ya., Muwais, Z., & Alsaleh, R. (2017). Polycystic ovary syndrome and vit D correlation with fertility: rewiev article. The Egypt J of Hosp Med, 69 (6). DOI: https://doi.org/10.12816/0042239

##submission.downloads##

Опубліковано

2020-03-04

Як цитувати

Khmil, M. S., Khmil, S. V., Chudiiovych, N. Y., Khmil-doswald, A. S., & Malanchuk, L. M. (2020). ЕФЕКТИВНІСТЬ ВИКОРИСТАННЯ ВІТАМІНУ D У КОМПЛЕКСНОМУ ЛІКУВАННІ БЕЗПЛІДДЯ У ЖІНОК ІЗ СИНДРОМОМ ПОЛІКІСТОЗНИХ ЯЄЧНИКІВ . Актуальні питання педіатрії, акушерства та гінекології, (2), 103–110. https://doi.org/10.11603/24116-4944.2019.2.10912

Номер

Розділ

Акушерство та гінекологія