NEW APPROACHES IN PREVENTION OF UNFAVOURABLE PERITONEAL OUTCOMES IN WOMEN WITH MISCARRIAGE

Authors

  • M. O. Shcherbyna Kharkiv National Medical University
  • O. P. Lipko Kharkiv National Medical University
  • I. M. Shcherbyna Kharkiv National Medical University
  • O. V. Mertsalova Kharkiv National Medical University
  • L. V. Potapova Kharkiv National Medical University

DOI:

https://doi.org/10.11603/24116-4944.2019.1.10205

Keywords:

cervical weakness, connective tissue dysplasia, hyaluronic acid

Abstract

The aim of the study – to improve the effectiveness of prevention strategies of perinatal outcomes in women with miscarriage. The method employed included the optimization of pre-conception care. Specifically we aimed to develop new methods of treatment of cervical insufficiently based on the treatment of 56 pregnant female patients who underwent traditional and alternative methods of cervical insufficiently treatment.

Materials and Methods. We studied pregnancy and labour among 56 female patients (pregnant with one child only) with cervical insufficiently. Both laboratory and clinical methods were employed to study metabolic state of tissue. Furthermore, immunobiology testing as well as microcirculation in the cervical vessels was examined. The data obtained in the study was statistically analysed.

Results and Discussion. The analysis revealed the future directions of the development of the therapy of miscarriage and prevention of perinatal loss. The strategy proposed incorporates fillers containing hyaluronic acid into the treatment of women with cervical insufficiently in order to stimulate physiological processes of the connective tissue of the cervix during the subsequent pregnancy.

Conclusions. The main determinants of cervical insufficiently and miscarriage include clinical manifestation of connective tissue dysplasia, biochemical pathology of collagen and glycosamides metabolism, immunological dysfunction and local lesions of the microcirculation. Treatment of cervical insufficiently using fillers containing hyaluronic acid shows clear advantage over the traditional methods of treatment and is an important strategy in prevention of negative perinatal outcomes in women with miscarriage.

References

Strizhakov, A.N., Davydov, A.I., Ignatko, I.V., & Belotserkovtseva, L.D. (Eds.). (2011). Nevynashyvaniye beremennosti: patogenez, diagnostika, lecheniye. Klinicheskoye rukovodstvo [Miscarriage of pregnancy: pathogenesis, diagnosis, treatment. Clinical Guideline]. Moscow [in Russian].

Sadler, L., & Saftlas, A. (2007). Cervical surgery and preterm birth J. Perinat. Med., 35 (1), 5-9. DOI: https://doi.org/10.1515/JPM.2007.001

(2015). World Health Organization. Global Strategy for Women's and Children's Health, 2016-2030. Geneva. Retrieved from: http://www.who.int/pmnch/activities/jointactionplan/20100910_gswch_russian.pdf?ua=1.

Markin, L.B., & Prokip, U.Ye. (2014). Funktsionalna istmiko-tservikalna nedostatnist yak proiav nedyferentsioiovanoi DST [Functional cervical insufficiently manifestation of undifferentiated connective tissue dysplasia]. Collection of articles of Assosiation of Obstetricians-gynaecologists of Ukraine, Kyiv: Polіhraf plius [in Ukrainian].

Powrie, F., & Coffman, R. (2013). Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunology Today, 14, 270-275. DOI: https://doi.org/10.1016/0167-5699(93)90044-L

Tucker, M., Hees, A., & Hoffman, K. (1995). Precision of laser Doppler scanning in clinical use. Clinic. Exp. Dermat., 20, 371-376. DOI: https://doi.org/10.1111/j.1365-2230.1995.tb01352.x

Zhabchenko, I.A., Oleshko, V.F. (2015). The algorithm of obstetric actions in case of cervical insufficiency. Health of Women, 6 (102), 76-78.

Mongat, G.D., & Koleman, K.M. (2006). Fillers based on hyaluronic acid. Journal of Dermatology, 19, 141-150.

Petersen, L.K., Uldbjerg, N. (2013). Cervical collagen in non-pregnant women with previous cervical incompetence. Eur. J. Obstet. Gynecol. Reprod. Biol., 67 (1), 41-45.

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Published

2019-06-12

How to Cite

Shcherbyna, M. O., Lipko, O. P., Shcherbyna, I. M., Mertsalova, O. V., & Potapova, L. V. (2019). NEW APPROACHES IN PREVENTION OF UNFAVOURABLE PERITONEAL OUTCOMES IN WOMEN WITH MISCARRIAGE. Actual Problems of Pediatrics, Obstetrics and Gynecology, (1), 156–159. https://doi.org/10.11603/24116-4944.2019.1.10205

Issue

No. 1 (2019)

Section

OBSTETRICS AND GYNECOLOGY

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