HYPERPLASIA OF ENDOMETRIUM – A MODERN SYSTEM-PATHOGENETIC VIEW ON THE PROBLEM (LITERATURE REVIEW)
(LITERATURE REVIEW)
DOI:
https://doi.org/10.11603/24116-4944.2019.1.9906Keywords:
endometrial hyperplasia, oncological risk, apoptosis, steroid hormonesAbstract
Maintaining women's health and studying gender-related diseases remain priorities in medicine. The article is devoted to the actual problem of the present – hyperplastic processes of endometrium. In the problem of solving this pathology in recent years, a lot of information about etiology, causes of origin, diagnosis and treatment has been accumulated. The purpose of our search – a review of literature devoted to the factors of development, etiology and pathogenesis, which play the most important role in the development of hyperplastic processes of endometrium. The endometrium is a hormone-sensitive tissue that has the ability not only to cyclically renew almost all of the cellular composition, but also to a definite response to all changes in the hormones, cytokines, adhesion molecules, growth factors, biogenic amines and other biologically active substances at the level of the whole organism. The article deals with the main parts of the etiopathogene of this pathology, namely: an estrogenic stimulant, which is combined with progesterone deficiency, hormone-independent proliferation, inflammation, decreased apoptosis, pathological neoanogiogenesis, and also violations of the immune status in the endometrium. In addition, brief information is provided on new key elements of developmental factors, which contributes to a significant improvement in the problem resolution in the selection of pathogenetically valid diagnostic and treatment methods. The article shows that a normal cell growth process requires a delicate balance between hormones, growth factors and adhesion molecules, including integrin and apoptotic-linked genes. Revised literature sources point to a large number of cases of recurrent hyperplasia of the endometrium, which leads to increased control in the direction of onkocystrogenism. The new classification of endometrial hyperplasia (WH094) is proposed by the World Health Organization, which greatly simplifies the terminology and understanding of the problem for the clinician.
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