THE ROLE OF FOLIC ACID IN PREVENTING BIRTH DEFECTS: RESULTS OF ANONYMOUS QUESTIONNAIRES OF THE FEMALE POPULATION OF THE LVIV REGION

Authors

  • Ye. B. Sharhorodska Institute of Hereditary Pathology, National Academy of Medical Sciences of Ukraine, Lviv
  • O. S. Shkolnyk Institute of Hereditary Pathology, National Academy of Medical Sciences of Ukraine, Lviv
  • I. A. Potapov Institute of Hereditary Pathology, National Academy of Medical Sciences of Ukraine, Lviv
  • O. S. Rachkevych Institute of Hereditary Pathology, National Academy of Medical Sciences of Ukraine, Lviv
  • H. V. Makukh Institute of Hereditary Pathology, National Academy of Medical Sciences of Ukraine, Lviv

DOI:

https://doi.org/10.11603/24116-4944.2019.1.9888

Keywords:

pregnancy, congenital malformations, preconception prevention, folic acid

Abstract

The aim of the study – to learn the awareness of the female population of Lviv region about the role of folic acid (FA) in the prevention of fetus development congenital deformities.

Materials and Methods. A survey of pregnant women in the Lviv region was conducted and an analysis of 811 questionnaires of respondents was carried out. Following questions were researched about the medicine usage: dose (100, 200, 400 or 500 micrograms), before and during current pregnancy, the duration of the medicine intake, before conception and the first three months of pregnancy, as well as awareness of the population regarding the preconceptional effect of folic acid.

Results and Discussion. The analysis of the data of questionnaires showed that among 811 women, 622 lived in the city (76.69 %), and 189 (23.31 %) – in the village. The study of pregnancy parity showed that there were significantly more women with the 1st and 2nd pregnancy (48.20 % and 33.97 % respectively). Women who were the first to know about the importance of FA were pregnant for the first (30.83 %) and the second (25.40 %) time, many of them were residents of the city. Most of the respondents got to know about the FA from doctors – 58.08 %, and most of these women were rather from the city than from the village (46.0 % and 12.08 % respectively, P <0.001). Only 40.44 % used FA before pregnancy for one to three months. A total of about 1/3 (37.73 %) of women took FA in a dose of 400 micrograms. Moreover, 26.26 % of respondents used the medicine for 2 months before pregnancy and 41.92 % – for three months during pregnancy. Significantly, they were rather inhabitants of the city than villages (P <0.001).

Conclusions. It was established that among the female population of Lviv region, awareness of folic acid as the best genuine prevention of fetus development congenital deformities is not sufficient. This refers to the data on the medication itself, its dose and terms and duration of use.

References

Verteletskyi, V., Yevtushok, B., Zymak-Zakutnia, N., Kalynka, S., Korzhynskyi, Yu., Lapchenko, S., Sosyniuk, Z.

(2016). Vrodzheni vady rozvytku, Polissia, Chornobyl. [Congenital malformations, Polissia, Chornobyl]. Neonatolohiia, khirurhiia ta perynatalna medytsyna – Neonatology, Surgery and Perinatal Medicine, VI 2 (20), 5-14 [in Ukrainian].

Sharhorodska, Ye.B. (2018). Poshyrenist vrodzhenoi patolohii systemy krovoobihu u novonarodzhenykh ditei za danymy oblasnoi klinichnoi likarni m. Lvova ( 2011-2015 rr.) [The incidence of congenital pathology of the circulatory system in newborns according to the data of the Lviv Clinical Hospital (2011-2015)]. Bukovynskyi medychnyi visnyk – Bukovyna Medical Bulletin, 22 3(87), 105-109 [in Ukrainian].

Kumar, R.K. (2016). Screening for congenital heart disease in India: Rationale, practical challenges, and pragmatic strategies. Ann. Pediatr. Cardiol., 9 (2), 111-114. DOI: https://doi.org/10.4103/0974-2069.181499

Smith, M.A. (2015). Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study. The Lancet., 388 (10053), 1447-1850, e11.

Voyevodin, S.M., & Shemanayeva, T.V. (2018). Profilaktika vrozhdennykh porokov razvitiya u ploda (obzor literatury) [Prevention of congenital malformations in the fetus (review of literature)]. Sovremennye problemy zdravoohraneniya i meditsinskoy statistiki – Modern Problems of Public Health and Medical Statistics, 2, 86-93 [in Russian].

Balenko, L.M., & Olefirenko, I.V. (2016). Vady rozvytku orhanizmu liudyny: prychyny yikh vynyknennia [Wounds in the development of the human body: the causes of their occurrence]. Medychnyi forum – Medical Forum, 9 (09), 8-10 [in Ukrainian].

Sharhorodska, Ye.B., Shkolnyk, O.S., Makukh, H.V., & Helner, N.V. (2018). Vyvchennia kliniko-henealohichnykh osoblyvostei zhinok, shcho narodyly ditei z vrodzhenoiu patolohiieiu systemy krovoobihu [Study of clinical and genealogical characteristics of women who gave birth to children with congenital pathology of the circulatory system]. Odeskyi medychnyi zhurnal – Odesa Medical Journal, 5 (169), 69-74 [in Ukrainian].

Maher, M., & Keriakos, R. (2014). Women's awareness of periconceptional use of folic acid before and after their antenatal visits. Clin. Med. Insights Women’s Health, 1 (7), 9-15. doi: 10.4137/CMWH.S13535. eCollection 2014. DOI: https://doi.org/10.4137/CMWH.S13535

Wald, N.J. (2011). Commentary: a brief history of folic acid in the prevention of neural tube defects. Int. J. Epidemiol., 40, 1154-1156. DOI: https://doi.org/10.1093/ije/dyr131

Wallingford, J.B., Niswander, L.A., Shaw, G.M., & Finnell, R.H. (2013). The continuing challenge of understanding, preventing, and treating neural tube defects. Science, 339, 1222002. DOI: https://doi.org/10.1126/science.1222002

Zhang, T., Lou, J., Zhong, R., Wu, J., Zou, L., Sun, Y., Lu, X., et al. (2013). Genetic variants in the folate pathway and the risk of neural tube defects: a meta-analysis of the published literature. PLoS One, 8, e59570. DOI: https://doi.org/10.1371/journal.pone.0059570

Hozhenko, A., Kulbida, M., & Kochet, O. (2011). Profilaktychna stratehiia medychnoi nauky – shliakh do pidvyshchennia efektyvnosti okhorony zdorovia [The preventive strategy of medical science is a way to improve the efficiency of health care]. Visnyk NAN Ukrainy – Bulletin of the NAS of Ukraine, 12, 64-69 [in Ukrainian].

Imbard, A., Benoist, J.F., & Blom, H.J. (2013). Neural tube defects, folic acid and methylation. Int. J. Environ. Res. Public Health, 10, 4352-4389. DOI: https://doi.org/10.3390/ijerph10094352

Czeizel, A., Dudás, I., Vereczkey, A., & Bánhidy, F. (2013). Folate deficiency and folic acid supplementation: The prevention of neural-tube defects and congenital heart defects. Nutrients, 5 (11), 4760-4775. DOI: https://doi.org/10.3390/nu5114760

Kuznetsova, I.V., & Konovalov, V.A. (2014). Foliyevaya kislota i ee rol v zhenskoy reproduktsii [Folic acid and its role in female reproduction]. Ginekologiya – Gynecology, 4, 17-23 [in Russian].

Marapov, D.I. (2015). Sovershenstvovaniye pervichnoy profilaktiki vrozhdennykh porokov razvitiya v respublike Tatarstan: avtorefereat [Improving the primary prevention of congenital malformations in the Republic of Tatarstan: Extended abstract]. Kazan [in Russian].

Czeizel, A.E., Dudas, I., Paput, L., & Banhidy, F. (2011). Prevention of neural-tube defects with periconceptional folic acid, methylfolate, or multivitamins? Ann. Nutr. Metab., 58 (4), 263-271.

Donnikov, A.E. (2016). Endre Cejzel i konceptsiya pervichnoy profilaktiki vrozhdennykh porokov razvitiya ploda [Endre Zeisel and the concept of primary prevention of congenital malformations of the fetus]. Ginekologiya – Gynecology, 18 (4), 26-30 [in Russian].

Bhutta, Z.A., Das, J.K., & Bahl, R. (2014). Can available interventions end preventable deaths in mothers, newborn babies, and stillbirths, and at what cost? Lancet, 384 (9940), 347-370. DOI: https://doi.org/10.1016/S0140-6736(14)60792-3

Almeida, L.C., & Cardoso, M.A. (2010). Recommendations for folate intake in women: implications for public health strategies. Cad. Saude Publica, 26 (11), 2011-2026. DOI: https://doi.org/10.1590/S0102-311X2010001100003

McNulty, B., McNulty, H., Marshall, B., Ward, M., Molloy, A.M.,

Scott, J.M. et al. (2013). Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of folic acid supplementation in the second and third trimesters.

Am. J. Clin. Nutr., 98, 92-98.

Su, W., Zhu, P., & Wang, R. (2017). Congenital heart diseases and their association with the variant distribution features on susceptibility genes. Clin. Genet., 91 (3), 349-354. doi: 10.1111/cge.1283.5.

Smith, M.A., & Lau, C. (2015). A resolution on folic acid fortification. Birth Defects Res. A Clin. Mol. Teratol., 103 (1), 1-2. DOI: https://doi.org/10.1002/bdra.23339

Yevtushok, B.A., & Horovenko, N.H. (2016). Obiznanist zhinok reproduktyvnoho viku Rivnenskoi oblasti shchodo profilaktychnoho znachennia foliievoi kysloty [Knowledge of women of reproductive age in the Rivne region regarding the prophylactic value of folic acid]. Medychnyi forum – Medical Forum, 9 (09), 38-41 [in Ukrainian].

Published

2019-06-10

How to Cite

Sharhorodska, Y. B., Shkolnyk, O. S., Potapov, I. A., Rachkevych, O. S., & Makukh, H. V. (2019). THE ROLE OF FOLIC ACID IN PREVENTING BIRTH DEFECTS: RESULTS OF ANONYMOUS QUESTIONNAIRES OF THE FEMALE POPULATION OF THE LVIV REGION. Actual Problems of Pediatrics, Obstetrics and Gynecology, (1), 146–151. https://doi.org/10.11603/24116-4944.2019.1.9888

Issue

Section

OBSTETRICS AND GYNECOLOGY