THE ROLE OF HEMOSTASIS SYSTEM IN PATHOGENESIS OF REPRODUCTIVE LOSSES
DOI:
https://doi.org/10.11603/24116-4944.2019.1.9663Keywords:
miscarriage, platelets, fibrinogen, platelet aggregationAbstract
The aim of the study – to evaluate changes in some hemostatic indices in the first trimester of pregnancy in women with spontaneous abortion.
Materials and Methods. We examined 153 pregnant women who had been in inpatient treatment at the Gynecological Department of the Municipal Health Care Facility “City Clinical Maternity Hospital No. 1, and are also registered in the Well-Woman Clinic No. 1. Among them, 30 women were with uncomplicated pregnancy for 6–12 weeks (Group I), 60 women were with the threat of miscarriage (Group II), 34 women were with spontaneous abortion (Group III) and 29 women were with blighted ovum (Group IV).
Results and Discussion. At the time of the survey the violations in the hemostasis system were revealed in most cases of early pregnancy loss, indicating an increase in the potential for blood coagulation (hypercoagulation). Thus, the index of activation of the internal coagulation pathway is a decrease in the value of the activated partial thromboplastin time (P <0.05). The number of fibrinogen in a group with unauthorized termination of pregnancy and blighted ovum is twice that in case of uncomplicated pregnancy in the first trimester (P <0.05). The analysis of aggregation activity of platelets in patients with early pregnancy loss revealed a small, but a significant increase in platelet aggregation compared to an indicator in case of physiological pregnancy (P <0.05).
Conclusion. The changes of the system of hemostasis are observed in women with miscarriages, which are manifested by the phenomena of hypercoagulation and activation of the internal pathway of blood coagulation.
References
Blencowe, H., Cousens, S., Chou, D., Oestergaard, M., Say, L., Moller, A.-B., … & Lawn, J. (2013). Born too soon: the global epidemiology of 15 million preterm births. Reprod. Health, 10, S2. doi: 10.1186/1742-4755-10-S1-S2. DOI: https://doi.org/10.1186/1742-4755-10-S1-S2
Tkachenko, V.B., Razdaibiedina, A.S., & Vorobiova, I.I. (2018). Otsinka ryzyku spontannoho vykydnia zalezhno vid henetychnykh kharakterystyk zhinky [Assessment of the risk of spontaneous miscarriage depending on the genetic characteristics of a woman]. Perynatolohiia i pediatriia. Ukraina – Perinatology and Pediatrics Ukraine, 1 (73), 74-79 [in Ukrainian].
Riepina, M.A., Sumska, H.F., & Lapina, E.N. (2008). Nasledsvennye narusheniya sistemy gomeostaza i beremenost: metodicheskiye rekomendatsii [Hereditary disorders of the hemostatic system and pregnancy: Methodical recommendations]. Aylamazyana, (E.K.) (Ed.). Saint-Petersburg: Iz-vo N-L [in Russian].
Makatsariya, V.O. (Ed.). (2007). Antyfosfolipidnyy sindrom – imunnaya trombofiliya v akusherstve i ginekologii [Antiphospholipid syndrome – the immune thrombophilia in obstetrics and gynecology]. Moscow: Triada-KH [in Russian].
Vasilenko, I.A., Tychynskiy, V.P., & Valov, A.L. (2009). Kletochnaya diagnostika vozmozhnosti vitalnoy kompyuternoy mikroskopii [Cellular diagnostics of the possibility of the vital computed microscopy]. Vestnik poslediplomnogo meditsinskogo obrazovaniya – Bulletin of Postgraduate Medical Education, 3-4, 64-68 [in Russian].
Demidova, Ye.M., Radzinskiy, V.E., & Voloshchuk, G.G. (2006). Znacheniya lokalnykh kletochnykh vzayemodeystviy v endometrii v protsese vynashyvaniya beremenosti [The importance of local cellular interactions in the endometrium during pregnancy]. Pytannia hinekolohii, akusherstva ta perynatolohii – Questions of Qynecology, Obstetrics and Perinatology, 5, 1, 67-74 [in Russian].
Olusola, A.D. (2012). Endotelialnaya disfunktsiya v geneze rannikh reproduktivnykh poter [Endothelial dysfunction in the genesis of early reproductive loss]. Candidate’s Extended abstract. Moscow [in Russian].
Quenby, S., Farquharson, R.G., & Dawoodetal, F. (2015). Recurrent miscarriage and long-term thrombosis risk: a case-control study. Hum. Reprod., 20, 6, 1729-1732.
(2016). Fiziologichiskiye izmeneniya v organizme zhenshchiny vo vremya beremenosti [Physiological changes in the body of a woman during pregnancy]. Novosti meditsyny i farmatsii – News of Medicine and Pharmacy. Retrieved from: http://www.mif-ua.com/education/symposium/fiziologicheskie-izmeneniya-v-organizme-zhenshiny-vo-vremya-beremennosti [in Russian].
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
