EFFECTIVENESS OF INHALATION GLUCOCORTOCOSTEROIDS IN THE PRESENCE OF DIFFERENT INFLAMMATORY PHENOTYPES OF BRONCHIALASTHMA IN SCHOOL AGE CHILDREN

Authors

  • Ye. P. Ortemenka
  • L. O. Bezrukov
  • O. K. Koloskova

DOI:

https://doi.org/10.11603/24116-4944.2009.1.9616

Keywords:

bronchial asthma, children, type of inflammation, anti-inflammatory therapy, effectiveness of treatment

Abstract

In terms of clinical- epidemiologic evaluation of effectiveness of monotherapy of childhood bronchial asthma by inhalation corticosteroids, their greater effect has been determined under eosinophilic type of bronchial inflammation, but insufficiency of asthma control in presents of neutrophilic inflammatory process of airways.

References

1. Zbirnyk № 2 nakaziv MOZ Ukra ny / [pidhotov. Chernivetskym obl. oseredkom Asotsiatsi pediatriv Ukrainy].- Chernivtsi: PP Val L.O., 2006. - 391 p.
2.Mehuys E. Effectiveness of pharmacist intervention for asthma control improvement / E. Mehuys, L. Bortel, L. Bolle [et al.] // Eur. Respire. J. - 2008. - Vol. 31. - P. 790-799.
3. Simon D. Eosinophilc disorder/D. Simon, H-U. Simon //J. Allergy Clin. Immunol. - 2007. - Vol. 119. - P. 12911300.
4. Chapman K.R. Safer Inhaled Corticosteroid Therapy for Asthma/K.R. Chapman//Pediatrics. - 2008. Vol. 121. -P.179-180.
5. Zhang X. Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone /X. Zhang, E. Moilanen, H. Kankaanranta//Eur. J. Pharmacol.
- 2000. - Vol. 406. - P. 325-332.
6. Covar R.A. Safety and application of induced sputum analysis in childhood asthma / R.A. Covar, J.D. Spahh, R.J. Martin [etal.] //AllergyClin. Immulon. - 2004. -Vol. 114, N. 3. -P. 575-582.
7. Douwes J. Non-eosinophilic sthma: inporrance and possible mechanisms /J. Douwes, P. Gibson [etal.] //Thorax. - 2004. - Vol. 57. - P. 643-648.
8. Berry M.A. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma/M.A. Berry, A. Morgan [etal.]//Thorax. -2007. - Vol. 62. -P. 1043-1049.
9. Pavord I.D. The use of induced sputum to investigate airway inflammation / I.D. Pavord, M.M. Pizzichini [et al.] //Thorax. - 1997. - Vol. 52. - P. 498-501.
10. Tsoumakidou M. Airway inflammation and cellular stress in noneosinophilic atopic asthma / M. Tsoumakidou, E. Papadopouli [et al.]//Chest. - 2006. - Vol.129, N5. - P. 1194-1202.
11. Boulet L- P. How should we quantify asthma control?: a proposal / L-P. Boulet, V. Boulet, J. Milot // Chest- 2002.- Vol. 122. - P. 2217-2223.
12. Li J.T. Attaining optimal asthma control: a practice parameter/J.T. Li, J. Oppenheimer, I.L. Bernstein, R.A. Nicklas // J. Allergy Clin. Immunol. - 2005. - Vol. 116, N. 5. - P. S3-S11.

Published

2018-11-16

How to Cite

Ortemenka, Y. P., Bezrukov, L. O., & Koloskova, O. K. (2018). EFFECTIVENESS OF INHALATION GLUCOCORTOCOSTEROIDS IN THE PRESENCE OF DIFFERENT INFLAMMATORY PHENOTYPES OF BRONCHIALASTHMA IN SCHOOL AGE CHILDREN. Actual Problems of Pediatrics, Obstetrics and Gynecology, (1). https://doi.org/10.11603/24116-4944.2009.1.9616

Issue

Section

PEDIATRICS