CORRELATIVE RELATIONS BETWEEN ADIPOKINES AND INSULIN RESISTANCE IN WOMEN WITH THE POLYCYSTIC OVARY SYNDROME AND OBESITY
DOI:
https://doi.org/10.11603/24116-4944.2018.2.9541Keywords:
leptin, adiponectin, insulin resistance, polycystic ovary syndromeAbstract
The aim of the study – to define the correlation between adipokines and insulin resistance (IR) indices by studying the content of leptin and adiponectin in the blood of women with polycystic ovary syndrome (PCOS).
Materials and Methods. 45 patients with PCOS have been examined. Control group involved 20 healthy women. The study investigated the levels of leptin and adiponectin, hormonal markers of hyperandrogenemia and parameters of insulin resistance in women's blood. Hormones and adipokines have been identified with ECLIA immunoassay together with automatic analyzers and reagents from Roche Diagnostics (Germany). besity was verified by the body mass index (BMI). IR was evaluated by NOMA index.
Results and Discussion. Obese patients with PCOS experience hyperleptinemia and hypoadiponectinemia, increasing directly proportional to their BMI. The high concentration of leptin positively correlates with IR parameters. In a group of women with PCOS we haven’t identified any statistically significant correlations between serum adiponectin concentration and hormonal indices. However, there has been identified a significant negative relationship between the concentration of adiponectin and BMI in the blood serum.
Conclusions. Hyperleptinemia and hypoadiponectinemia arising as a result of obesity, trigger the development of IR and hyperinsulinemia, which stimulates steroidogenesis in the theca cells of the ovary, provokes dysfunction in the hypothalamus-pituitary-ovarian system and leads to the development of PCOS. Adipokines (leptin and adiponectin) can serve as a link with which obesity and IR provoke the PCOS development as well as the sexual and reproductive dysfunctions in women.
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