ANALYSIS OF HORMONAL CHANGES IN WOMEN WITH BACKGROUND AND PRECANCEROUS PROCESSES OF THE CERVIX

Authors

  • A. V. Boychuk ДВНЗ «Тернопільський державний медичний університет імені І. Я. Горбачевського МОЗ України», Тернопіль
  • V. V. Sopel ДВНЗ «Тернопільський державний медичний університет імені І. Я. Горбачевського МОЗ України», Тернопіль
  • B. M. Begosh ДВНЗ «Тернопільський державний медичний університет імені І. Я. Горбачевського МОЗ України», Тернопіль
  • V. O. Khudobiak Пологовий будинок Рівненської міської ради, Рівне
  • O. V. Sopel ДВНЗ «Тернопільський державний медичний університет імені І. Я. Горбачевського МОЗ України», Тернопіль

DOI:

https://doi.org/10.11603/24116-4944.2018.2.8940

Keywords:

mechanical injuries of the cervix, hormonal disorders, infectious diseases of the cervix and vagina, viruses and chlamydia, violation of the immune status of the organism, precancerous processes, endocrine dysfunction

Abstract

The aim of the study – to evaluate the peculiarities of the course of diseases of the cervix according to hormonal disorders.

Materials and Methods. According to the purpose of the study, under our supervision, there were 105 women aged 18 to 42 years old. The average age of the examined was (25.92±0.61) years. Criteria for inclusion of patients in the study were abnormal processes of the cervix and menstrual disorder. All women underwent a general-clinical examination, envisaged by the Order of the Ministry of Health of Ukraine No. 676 dated December 31, 2004 (examination of the cervix in the mirror, microscopy of the vaginal smears, Pap test, colposcopy and, if necessary, a cervical biopsy), as well as additional clinic-laboratory examination methods: PCR detection by PCR in a cervical canal scan and hormonal examination (determination of levels of dihydrotestosterone, prolactin, androstenediol glucoronide, 17-ketoesteroids, free testosterone index, follicle stimulating hormone levels, luteinism hormone, estradiol (E2), dihydroepiandrosterone sulfate for 2–3 days and 21–22 days of the menstrual cycle).

Results and Discussion. The increased of androgen levels above the reference values ​​were found in 14 (35.0 %) patients of the group 1 and in 23 (57.5 %) patients of the group 2. A decreased of progesterone level was observed in 11 (27.5 %) women of the group 1 and in 15 (37.5 %) patients of the group 2. Increasing of estrogenes levels were noted in 5 (12.5 %) patients of the group 1 and in 4 (10.0 %) women of the group 2.

Conclusion. Analyzing the performed studies, we found the following variants of hormonal disorders in patients with cervical diseases:

- ILF (insufficiency of the luteal phase) was found in 65.0 % of patients;

- PCOS (polycystic ovary syndrome) was found in 22.5 % of patients;

- HPI (hypothalamic-pituitary insufficiency) was found in 5.0 % of women.

Author Biography

A. V. Boychuk, ДВНЗ «Тернопільський державний медичний університет імені І. Я. Горбачевського МОЗ України», Тернопіль

 

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Published

2018-11-19

How to Cite

Boychuk, A. V., Sopel, V. V., Begosh, B. M., Khudobiak, V. O., & Sopel, O. V. (2018). ANALYSIS OF HORMONAL CHANGES IN WOMEN WITH BACKGROUND AND PRECANCEROUS PROCESSES OF THE CERVIX. Actual Problems of Pediatrics, Obstetrics and Gynecology, (2), 27–32. https://doi.org/10.11603/24116-4944.2018.2.8940

Issue

No. 2 (2018)

Section

OBSTETRICS AND GYNECOLOGY

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