MEMBRANE-DESTRUCTIVE PROCESSES AND ANTIOXIDANT DEFENSE SYSTEM AT IRON DEFICIENCY ANEMIA IN CHILDHOOD
DOI:
https://doi.org/10.11603/24116-4944.2018.1.8798Keywords:
antioxidant defense system, lipid peroxidation, malonic dialdehyde, iron deficiency anemia.Abstract
The article presents numerous literature data on the activation of lipid peroxidation at various pathologies in childhood. Excess of iron in the body may be the initiator of oxidation reactions, the cause of an increase production of hydroxyl radicals that damage the cells, which gives grounds to belong anemia to the diseases that are characterized by membrane pathology. It was established that iron deficiency with a wide range of known negative influences on the body, activates the processes of free radical oxidation in tissues and leads to imbalance in antioxidant defense system. The correlation dependence between iron deficiency and concentration of the final products of lipid peroxidation was discovered – malonic dialdehyde: when iron decreased, the level of malonic dialdehyde increased so iron acts as a catalyst for lipid peroxidation. Membrane-destructive and metabolic changes in erythrocytes which arise as a result of the activation of free radical oxidation of lipids and changes in the activity of antioxidant enzymes inhibit its functional activity, that contributes to the growth of hypoxia and the accumulation of toxic metabolites in the body.References
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