"THERAPEUTIC WINDOW" IN DRUG TREATMENT OF THE GENITO-URINARY MENOPAUSAL SYNDROME IN WOMEN
DOI:
https://doi.org/10.11603/24116-4944.2018.1.8796Keywords:
genitourinary menopausal syndrome, genitourinary dysfunction, index of vaginal health, urinary incontinence.Abstract
The aim of the study – to investigate the effectiveness of the medication treatment of the genito-urinary menopausal syndrome in women, depending on its duration.
Materials and Methods. 78 women aged 48–74 with menopausal genito-urinary disorders were examined. Depending on the duration of the menopausal genitourinary syndrome, the patients were divided into three groups: up to 3 years – Group I, 3–5 years – Group II, more than 5 years – Group III. All patients had been given the same drug therapy for 6 months, which included estrogen-containing drug, phyto-uroseptic and anxiolytic. It was also strongly recommended to follow certain dietary rules and perform Kegel exercises daily. All patients were routinely clinically and laboratory tested, according to the current clinical protocols. The severity of the genitourinary dysfunction was assessed using the vaginal health index of G. Bachmann and D. Barlow scale. To determine the stress urinary incontinence stage, the daily Pad test was used by ICS.
Results and Discussion. The patients suffering from the genitourinary dysfunction for not more than 5 years (group I and II) had atrophic changes in the vagina, however, among women in group III, this figure was 20.8 %. The average score of vaginal health index before the treatment in group I was (3.65±0.49), in group II – (3.39 ± 0.49), in group III – (2.88±0.54). The mean score of subjective manifestation of the menopausal genitourinary dysfunction symptoms before the treatment in patients of group I was (1.92±0.56) points, group II – (2.36±0.62) points, group III – (3.08±0.65) points. The results of the study after the completion of the treatment showed a significant positive clinical dynamics in women of I group, in whom the duration of menopausal disorders lasted not more than 3 years.
Conclusions. One of the decisive factors in the treatment of menopausal genitourinary disorders is the time factor. The best results in correction of this pathology are achieved if its duration is not more than 3 years. In longer duration, the effectiveness of the treatment becomes smaller and rather ineffective.
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