PREVENTION OF PLACENTARY DYSFUNCTION BY USE OF FOLATS
DOI:
https://doi.org/10.11603/24116-4944.2018.1.8794Keywords:
prevention, placental dysfunction, folates.Abstract
The aim of the study – to reduce the frequency of placental dysfunction by using folates prior to pregnancy and by trimester of gestation.
Materials and Methods. We examined 60 women of reproductive age who took the vitamin-microelemental-amino acid complex of Natalker II and standard pregravid preparation. The content of folic acid, the alleles of the enzyme gene of the folate cycle of methylenetetrahydrofolate reductase was determined, the analysis of the course of gestation was carried out, the placenta was examined.
Results and Discussion. For fertilization, normal folate values in group I were 100.0 %, in group II – 76.7 %. The normal folate level in the third trimester in group I was 100.0 %, in group II – 43.3 %. Polymorphism of the gene methylenetetrahydrofolate reductase was in 63.3 % of women. Gestational complications significantly prevailed in group II. The expressive development of adaptive and compensatory processes was revealed in placentas of women of group I. Compensatory-adaptive reactions in the placenta of women of group II were absent, or decreased.
Conclusions. The intake of the vitamin and microelemental amino acid complex of Natalker II at the stage of preconception preparation for 3 months and Natalker I to 12 weeks of pregnancy and Natalker II from 13 weeks before the term of labor confirms its effectiveness.
References
Aylamazyan, E.K., Kulakov, V.I., Radzinskiy, V.E., & Savelyeva, G.M. (2013). Akusherstvo: natsionalnoye rukovodstvo [Obstetrics: national leadership]. Moscow: GEOTAR [in Russian].
Nedzved, M.K., & Cherstvyy, E. (2011). Patologicheskaya anatomiya: uchebnoye posobiye [Pathological anatomy: a textbook]. Minsk: Vysh. shk. [in Russian].
Mishchenko, V.P. (1998). Platsentarnaya nedostatochnost v sovremennoy ekologicheskoy situatsii (diagnostika, profilaktika i lecheniye) [Placental insufficiency in the current ecological situation (diagnosis, prevention and treatment)]. Extended abstract of Doctor’s thesis. Odesa [in Russian].
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