CONCEPT OF IMPROVEMENT OF DIAGNOSTIC ALGORITHM IN POSPARTUM PURULENT INFLAMMATORY DISEASES
DOI:
https://doi.org/10.11603/24116-4944.2018.1.8762Keywords:
endometritis, fluorescence spectroscopy, postpartum suppurative inflammatory diseases.Abstract
The aim of the study – to improve the diagnosis and prediction of the development of postpartum endometritis by using the method of fluorescence spectroscopy.
Materials and Methods. Experimental part (first stage of research) – dilution of serum of blood by 6-day crops of a sugar broth with Staphylococcus aureus. Clinical part (second stage): serum of blood of the main group – 120 women with postpartum endometritis and control – 38 women with uncomplicated course of the postpartum period. Methods of research: clinical, laboratory, biochemical, instrumental, fluorescence spectroscopy, mathematical and statistical methods.
Results and Discussion. Fluorescence spectra of blood serum dilutions with bacterial culture (6-day crops of the sugar broth with Staphylococcus aureus), starting with 20 % of bacterial culturs, allow to reproduce proportions that are similar to spectralfluorescence characteristics of blood serum in sepsis in vivo. In the mothers with postpartum endometritis, it was found that in90,.8 % of the patients in the main group was observed a decrease in the serum fluorescence intensity blood, p <0.0001, and in 38.3 % there was a long-wave shift of fluorescence spectra of blood serum, p = 0.007 (statistically significant differences). The received characteristics are fixed for 24–48 hours before the manifestation of the expressed clinical manifestations of the disease.
Conclusions. The use of spectrum-fluorescent serum markers in the complex diagnosis of purulent-inflammatory diseases, including postpartum endometritis, allows to make the reliably diagnose of this disease before the appearance of pronounced clinical manifestations.
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