PLACENTA ANGIOGENESIS DISTURBANCE IN SYPHILIS
DOI:
https://doi.org/10.11603/24116-4944.2018.2.8748Keywords:
placenta, angiogenesis, capillaries, syphilisAbstract
The aim of the study – to determine the method of correction of placental insufficiency treatment on the ground of determination of placenta state and quantity of capillares in term villi.
Materials and Methods. The materials of research were labor case records, afterbirths of 32 untreated patients and 30 healthy women, who gave birth in Lviv Regional Clinical Perinatal Center and Lviv Regional Clinical Hospital in 2007– 2014. The methods of research were clinical, biochemical, serological, immunofermental, USE, bacterioscopic, pathohistological, morphometric, medical statistical methods. Pathohistological research of afterbirths was carried out after coloration by means of haematoxylin and eosin. These were defined number of capillaries in 505 terminal villi of placenta in untreated patients and healthy women.
Results and Discussion. It was defined that obstetrical and perinatal complications in syphilis is caused by chronic placental insufficiency of inflammatory genesis: inflammatory changes, violation of uteral-placental-fetal circulation, involutive-degenerative (fibrosis of villi stroma, sediment of intrаvilli fibrinoid) and post-inflammatory changes (focal petrification) in placenta. Morphometric research has found out preference of hypovascularized terminal villi with reduction of number of capillaries in placentae of untreated women. There were found out pathogenic mechanisms of chronic placental insufficiency: 1) reduction of diffusion and perfusion volume of placenta; 2) hypovascularization of placenta as a result of reduction of number of normally vascularized villi, the number of capillaries in terminal villi and obliteration of vascular bed of villi; 3) morphofunctional immaturity of placenta; 4) involutive-degenerative changes of placenta (fibrosis of villi stroma, sediment of intravilli fibrinoid).
Conclusion. Syphilis cause chronic placental insufficiency, one of it pathogenetical mechanism is placenta hypovascularization with decrease of quantity of normal vascularized villi and capillares in hypovascularized term villi.
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