GENETIC PREDICTORS OF EXERCISE-INDUCED BRONCHIAL ASTHMA IN CHILDHOOD.
DOI:
https://doi.org/10.11603/24116-4944.2016.2.6834Keywords:
children, bronchial asthma, physical stress, gene polymorphism.Abstract
A complex clinic and spirographic investigation of schoolchildren suffering from exercise-induced bronchial asthma was held depending upon the presence or the absence of genes polymorphism of the enzymes of glutation-S-transferase T1M1 and gene mutation eNOS. The study showed that bronchial asthma physical effort associated with the polymorphism gene glutathione-S-transferase T1 and M1 (GSTT1del/GSTM1del). It is noted that the maximum bronchospasm on physical stress tests occur in children with genotype GSTT1del/GSTM1+, minimum bronhodylation influenced by the inhalation of 200 mcg salbutamol genotype GSTT1+/GSTM1+ and eNOS/GT, which necessitates a relatively active desobstructive therapy during exacerbations, although genotype GSTT1+/GSTM1del associated with the need for the minimum amount of this medication.References
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