A PATHOGENETIC ROLE OF MELATONIN AND CORTISOL IN A PRIMARY ARTERIAL HYPERTENSION FORMATION IN CHILDHOOD
DOI:
https://doi.org/10.11603/24116-4944.2014.1.6610Abstract
The primary arterial hypertension (PAH) pathogenesis in children, particularly the role of melatonin and Cortisol, is discussed in the article. We examined 64 children 11-16 years old with various forms of PAH according to the daily blood pressure monitoring (ABPM ) and ЗО children of control group with normal blood pressure (BP). A concentration of 6- sulfatoxymelatonin (6- SOMT) and "free" cortisol in day and night urine were determined in all children. It was revealed that PAH in children 11-16 years old is accompanied by epiphysis melatonin produсtion disturbances , which is manifested by increased daily excretion of 6-SOMT in the urine and by decreased its nocturnal excretion to ЗО,68±4,76 ng/ml in children with labile PAH and increased nocturnal excretion to
52,О2±2,7О ng/ml in children with stable PAH.Epiphysis melatoninprodutive function increases as a compensatory response to increased cortisol level, which urinary excretion in children with stable PAH was within 157,59±12,О ng/ml for a daytime period and 11О,З7±7,9З ng/ml for a night-time period. The crisis PAH is formed in the case of relatively low night melatonin production compared to its daily production. The stabilization of hypertension is formed in the case of relatively high night-time melatonin production. Decreased ratio of night melatonin excretion to its day excretion and decreased ratio of day cortisol excretion to its nocturnal excretion are factors in the formation of insufficient nocturnal BP reduction in children with PAH.
References
Arteryalʹnaya hypertenzyya u podrostkov - stratehyya antyhypertenzyvnoy terapyy / N. M. Korenev, L. F. Bohmat, Y. D. Cavvo, E. M. Nosova //Ukr. kardyol. zhurn. - 2OO6. - l e ts . vypusk. - C. 82-85.
Arterialʹna hipertenziya. Onovlena ta adaptovana klinichna nastanova, zasnovana na dokazakh (2O12 rik) : ro bocha'hrupa'z'arterialʹnoyi'hipertenziyi'Ukrayinsʹkoyi'asotsiatsiyi kardiolohiv (2OO8 r.) //Arterialʹna hipertenziya. - 2O12. - № 1 . - C . 96-152.
Riley M., Bluhm B. High blood pressure in children and adolescents/Am Fam Physician, 2О12. - № 85(7). - Р. 69З- 7ОО.
'Experimental'models'of'melatonin-deficient'hypertension / Simko F., Reiter R. J., Pechanova O., Paulis L. // Front Biosci, 2О1З. - Jan 1. - № 18. - Р. 616-625.
Zeman M., Herichova I. Melatonin and clock genes expression in the cardiovascular system. Front Biosci (Schol Ed), 2О1З. - Jan 1. № 5. - Р. 74З-75З.
Bendz L. M., Scates A. C. Melatonin treatment for insomnia'in'pediatric'patients'with'attention-deficit/hyperactivity disorder. /Ann Pharmacother, 2О1О. - №44. - Р.185-191.
Klynycheskoe znachenye opredelenyya pokazateley kortyzola v syvorotke krovy : obzor/L. C. Kalahyna// Klynycheskaya laboratornaya dyahnostyka. - 2O11. - № 2. - C. 23-25.
Stress reactivity and corticolimbic response to emotional faces in adolescents. / Liu J., Chaplin T. M., Wang F. etal. / / J Am Acad Child Adolesc Psychiatry. - 2О12. - №51 (З). - Р. ЗО4-З12.
Powell D. J., Schlotz W. Daily life stress and the cortisol awakening response: testing the anticipation hypothesis. PLoS One. - 2О12. - №7(12). - Р . Є 5 2 О 6 7 .
Downloads
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
