MULTIG ENIC THROMBOPHILIA IN PREGNANT WOMAN WITH PREECLAMPSIA.
DOI:
https://doi.org/10.11603/24116-4944.2016.1.5998Keywords:
pre-eclampsia, pregnancy, thrombophilia, genetic polymorphisms, risk factors.Abstract
In order to study the structure and frequency of mutagenic forms of thrombophilia in women with pre-eclampsia were examined 133 patients with varying severity of preeclampsia and 44 healthy pregnant women. Polymerase chain reaction was used to determine the presence of pathological polymorphisms in the genes of thrombophilia (factor V Leiden 1691 G→A, prothrombin 20210 G→A, inhibitor plasminogen activator type-1 5G / 4G, fibrinogen β 455 G→A), «endothelial dysfunction» (paraoxosonase-1 192 Q→R, methylenetetrahydrofolate reductase 677 C→T) and a regulator of blood pressure (angiotensinogen II 235 M→T). It was found that in the development of preeclampsia play the role pathologic polymorphisms, which are mainly found in women with pre-eclampsia. In the structure multigene forms of thrombophilia in mild pre-eclampsia predominated – 71.88 % and in pre-eclampsia moderate and severe degree – 79.7 %. It is noted that mild pre-eclampsia is characterized by the existence of two pathological polymorphisms simultaneously (OR 3.4; 95 % CI 1.47–7.88), preeclampsia moderate and severe degree three or more pathological polymorphism simultaneously (OR=10.51; 95 % CI 2.97–37.26). Lack of co-pathologic polymorphisms reduce the risk of development moderate, severe (OR=0.11; 95 % CI 0.04–0.26) and mild (OR=0.16; 95 % CI 0.07–0.38) preeclampsia.
References
WHO analysis of causes of maternal death: a systematic review / K. S. Khan, D. Wojdyla, L. Say [et al.] // Lancet. – 2006. – Vol. 367. – P. 1066–1074.
Profylaktyka povtornykh oslozhnenyy beremennosty v uslovyyakh trombofylyy : rukovodstvo dlya vrachey / A. D. Makatsaryya, V. O. Bytsadze, S. M. Baymuradova, E. B. Perederyaeva [y dr.]. – M. : «Tryada – KH», 2008. – 152 s.
Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: A population-based Swedish cohort study / S. Cnattingius, M. Reilly, Y. Pawitan, P. Lichtenstein // Am. J. Medical Genetics Part A. – 2004. – Vol. 130A. – P. 365–371.
Double inherited thrombophilias and adverse pregnancy outcomes: fashion or science? / G. Larciprete, F. Rossi, T. Deaibess [et al.] // J. Obstet. Gynaecol. Res. – 2010. – Vol. 36, No. 5. – R. 996–1002.
Thrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort / J. A. Lykke, L. A. Bare, J. Olsen [et al.] // J. Thromb. Haemost. – 2012. – Vol. 10, No. 7. – R. 1320–1325.
Thrombophilia is significantly associated with severe preeclampsia. Results of a large scale, case-controlled study / G. Mello, E. Paretti, L. Marozio [et al.] // Hypertension. – 2005. – Vol. 46. – P. 1270–1274.
Perinatal outcome in women with severe pregnancy complications and multiple thrombophilias / M. Kupferminc, E. Rimon, J. Ascher-Landsberg [et al.] // J. Perinat Med. – 2004. – Vol. 32, No. 3. – P. 225–227.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
